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12-Epinapelline

CAS# 110064-71-6

12-Epinapelline

Catalog No. BCN2800----Order now to get a substantial discount!

Product Name & Size Price Stock
12-Epinapelline: 5mg $40 In Stock
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Quality Control of 12-Epinapelline

Number of papers citing our products

Chemical structure

12-Epinapelline

3D structure

Chemical Properties of 12-Epinapelline

Cas No. 110064-71-6 SDF Download SDF
PubChem ID 102004858 Appearance Powder
Formula C22H33NO3 M.Wt 359.5
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CCN1CC2(CCC(C34C2CC(C31)C56C4CC(C(C5)C(=C)C6O)O)O)C
Standard InChIKey AZAZKLKDEOMJBJ-WMLJXHKFSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 12-Epinapelline

The roots of Aconitum kusnezoffii Reichb.

Biological Activity of 12-Epinapelline

Description12-Epinapelline is a natural product from Aconitum kusnezoffii Reichb.

Protocol of 12-Epinapelline

Structure Identification
Chemistry of Natural Compounds, 2005,41(5):609.

Crystal and Molecular Structure of 12-Epinapelline[Reference: WebLink]


METHODS AND RESULTS:
The article examines the crystal and molecular structure of 12-Epinapelline. Previous investigations showed that the conformation of ring A in crystal structures of napelline-type alkaloids depended on the presence or absence of an intramolecular H-bond between an alpha-oriented C1 hydroxyl and the N atom.
CONCLUSIONS:
Thus, ring A in 12-epilucidusculin had the boat conformation and in acophine it adopted the twist or chair conformation.

12-Epinapelline Dilution Calculator

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12-Epinapelline Molarity Calculator

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Preparing Stock Solutions of 12-Epinapelline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7816 mL 13.9082 mL 27.8164 mL 55.6328 mL 69.541 mL
5 mM 0.5563 mL 2.7816 mL 5.5633 mL 11.1266 mL 13.9082 mL
10 mM 0.2782 mL 1.3908 mL 2.7816 mL 5.5633 mL 6.9541 mL
50 mM 0.0556 mL 0.2782 mL 0.5563 mL 1.1127 mL 1.3908 mL
100 mM 0.0278 mL 0.1391 mL 0.2782 mL 0.5563 mL 0.6954 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 12-Epinapelline

Analgesic activity of diterpene alkaloids from Aconitum baikalensis.[Pubmed:25110090]

Bull Exp Biol Med. 2014 Aug;157(4):488-91.

We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-Epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene alkaloids of different structure. The antinociceptive effect of atisine alkaloids (12-Epinapelline N-oxide, songorine) was naloxonedependent and realized via opioid receptor modulation.

Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense.[Pubmed:24770754]

Bull Exp Biol Med. 2014 Mar;156(5):665-8.

We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-Epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene alkaloids exerted no ulcerogenic effect.

Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense.[Pubmed:22803106]

Bull Exp Biol Med. 2012 Feb;152(4):439-43.

The effects of complex extract from Aconitum baikalense on reparative regeneration of a plane dorsal skin wound were studied. Treatment with Aconitum baikalense tincture stimulated reparation and skin regeneration. The effects of the Aconitum baikalense alkaloids on functional activity of fibroblast precursors were studied in vitro by cultural methods. Mesaconitine, hypaconitine, songorine, napelline, and 12-Epinapelline N-oxide significantly stimulated the growth of colonies from fibroblast precursors. This indicated direct stimulation of fibroblasts by aconite alkaloids, which could be a mechanism of reparative activity of the complex extract.

Description

12-Epinapelline is a diterpene alkaloid isolated from Aconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors.

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