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12alpha-Hydroxygrandiflorenic acid

CAS# 63768-17-2

12alpha-Hydroxygrandiflorenic acid

Catalog No. BCN4823----Order now to get a substantial discount!

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12alpha-Hydroxygrandiflorenic acid: 5mg $989 In Stock
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Quality Control of 12alpha-Hydroxygrandiflorenic acid

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Chemical structure

12alpha-Hydroxygrandiflorenic acid

3D structure

Chemical Properties of 12alpha-Hydroxygrandiflorenic acid

Cas No. 63768-17-2 SDF Download SDF
PubChem ID 13858118 Appearance Powder
Formula C20H28O3 M.Wt 316.4
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,4S,5R,9R,12S,13R)-12-hydroxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadec-10-ene-5-carboxylic acid
SMILES CC12CCCC(C1CCC34C2=CC(C(C3)C(=C)C4)O)(C)C(=O)O
Standard InChIKey YKLRBAUBANVECM-SUIOEDAWSA-N
Standard InChI InChI=1S/C20H28O3/c1-12-10-20-8-5-15-18(2,6-4-7-19(15,3)17(22)23)16(20)9-14(21)13(12)11-20/h9,13-15,21H,1,4-8,10-11H2,2-3H3,(H,22,23)/t13-,14+,15+,18-,19-,20-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 12alpha-Hydroxygrandiflorenic acid

The herbs of Wedelia trilobata

Biological Activity of 12alpha-Hydroxygrandiflorenic acid

DescriptionStandard reference
In vitro

Specific 12α-hydroxylation of grandiflorenic acid by permeabilised fungus Fusarium graminearum.[Pubmed: 24650196 ]

Nat Prod Res. 2014;28(9):677-9.


METHODS AND RESULTS:
Biotransformation of grandiflorenic acid by permeabilised fungus Fusarium graminearum to yield its hydroxylation derivative, 12alpha-Hydroxygrandiflorenic acid, was studied. The biotransformed product was isolated by column chromatography and its structure was determined by mass spectrum and nuclear magnetic resonance analysis.
CONCLUSIONS:
Grandiflorenic acid was efficiently metabolised by the fungus. After 72 h, the substrate was almost completely converted into the product.

12alpha-Hydroxygrandiflorenic acid Dilution Calculator

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12alpha-Hydroxygrandiflorenic acid Molarity Calculator

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Preparing Stock Solutions of 12alpha-Hydroxygrandiflorenic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1606 mL 15.8028 mL 31.6056 mL 63.2111 mL 79.0139 mL
5 mM 0.6321 mL 3.1606 mL 6.3211 mL 12.6422 mL 15.8028 mL
10 mM 0.3161 mL 1.5803 mL 3.1606 mL 6.3211 mL 7.9014 mL
50 mM 0.0632 mL 0.3161 mL 0.6321 mL 1.2642 mL 1.5803 mL
100 mM 0.0316 mL 0.158 mL 0.3161 mL 0.6321 mL 0.7901 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 12alpha-Hydroxygrandiflorenic acid

Specific 12alpha-hydroxylation of grandiflorenic acid by permeabilised fungus Fusarium graminearum.[Pubmed:24650196]

Nat Prod Res. 2014;28(9):677-9.

Biotransformation of grandiflorenic acid by permeabilised fungus Fusarium graminearum to yield its hydroxylation derivative, 12alpha-Hydroxygrandiflorenic acid, was studied. The biotransformed product was isolated by column chromatography and its structure was determined by mass spectrum and nuclear magnetic resonance analysis. Grandiflorenic acid was efficiently metabolised by the fungus. After 72 h, the substrate was almost completely converted into the product.

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