Home >> Research Area >>Natural Products>>Alkaloids>> 14-Benzoylneoline

14-Benzoylneoline

CAS# 99633-05-3

14-Benzoylneoline

Catalog No. BCN6493----Order now to get a substantial discount!

Product Name & Size Price Stock
14-Benzoylneoline: 5mg $886 In Stock
14-Benzoylneoline: 10mg Please Inquire In Stock
14-Benzoylneoline: 20mg Please Inquire Please Inquire
14-Benzoylneoline: 50mg Please Inquire Please Inquire
14-Benzoylneoline: 100mg Please Inquire Please Inquire
14-Benzoylneoline: 200mg Please Inquire Please Inquire
14-Benzoylneoline: 500mg Please Inquire Please Inquire
14-Benzoylneoline: 1000mg Please Inquire Please Inquire

Quality Control of 14-Benzoylneoline

Number of papers citing our products

Chemical structure

14-Benzoylneoline

3D structure

Chemical Properties of 14-Benzoylneoline

Cas No. 99633-05-3 SDF Download SDF
PubChem ID 101028545 Appearance Powder
Formula C31H43NO7 M.Wt 541.7
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CCN1CC2(CCC(C34C2C(C(C31)C5(CC(C6CC4C5C6OC(=O)C7=CC=CC=C7)OC)O)OC)O)COC
Standard InChIKey GDNPLILPTBDDEP-GBLCJVDDSA-N
Standard InChI InChI=1S/C31H43NO7/c1-5-32-15-29(16-36-2)12-11-21(33)31-19-13-18-20(37-3)14-30(35,23(27(31)32)25(38-4)26(29)31)22(19)24(18)39-28(34)17-9-7-6-8-10-17/h6-10,18-27,33,35H,5,11-16H2,1-4H3/t18-,19-,20+,21+,22-,23+,24+,25+,26-,27-,29+,30-,31+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 14-Benzoylneoline

The roots of Aconitum carmichaeli

Biological Activity of 14-Benzoylneoline

Description14-Benzoylneoline is a natural product from Aconitum carmichaeli.
In vitro

Comparative normal/failing rat myocardium cell membrane chromatographic analysis system for screening specific components that counteract doxorubicin-induced heart failure from Acontium carmichaeli.[Pubmed: 24731167 ]

Anal Chem. 2014 May 20;86(10):4748-57.

Cell membrane chromatography (CMC) derived from pathological tissues is ideal for screening specific components acting on specific diseases from complex medicines owing to the maximum simulation of in vivo drug-receptor interactions. However, there are no pathological tissue-derived CMC models that have ever been developed, as well as no visualized affinity comparison of potential active components between normal and pathological CMC columns.
METHODS AND RESULTS:
In this study, a novel comparative normal/failing rat myocardium CMC analysis system based on online column selection and comprehensive two-dimensional (2D) chromatography/monolithic column/time-of-flight mass spectrometry was developed for parallel comparison of the chromatographic behaviors on both normal and pathological CMC columns, as well as rapid screening of the specific therapeutic agents that counteract doxorubicin (DOX)-induced heart failure from Acontium carmichaeli (Fuzi). In total, 16 potential active alkaloid components with similar structures in Fuzi were retained on both normal and failing myocardium CMC models. Most of them had obvious decreases of affinities on failing myocardium CMC compared with normal CMC model except for four components, talatizamine (TALA), 14-acetyl-TALA, hetisine, and 14-Benzoylneoline. One compound TALA with the highest affinity was isolated for further in vitro pharmacodynamic validation and target identification to validate the screen results.
CONCLUSIONS:
Voltage-dependent K(+) channel was confirmed as a binding target of TALA and 14-acetyl-TALA with high affinities. The online high throughput comparative CMC analysis method is suitable for screening specific active components from herbal medicines by increasing the specificity of screened results and can also be applied to other biological chromatography models.

Protocol of 14-Benzoylneoline

Structure Identification
Chemical & pharmaceutical bulletin, 1985, 33(9), 3658-61.

Studies on the constituents of Aconitum species. III. On the components of Aconitum subcuneatum NAKAI.[Reference: WebLink]


METHODS AND RESULTS:
A new alkaloid, 14-Benzoylneoline, and four known alkaloids, neoline, karakoline, 14-acetyldelcosine, and penduline, were isolated from the roots of Aconitum subcuneatum NAKAI. The structures of 14-Benzoylneoline and penduline were confirmed by derivation of these compounds from neoline and aconitine, respectively.
CONCLUSIONS:
A radical-type deoxygenation of a bridgehead hydroxyl group at C-13 was used in the transformation of aconitine into penduline through three steps.

14-Benzoylneoline Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

14-Benzoylneoline Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 14-Benzoylneoline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.846 mL 9.2302 mL 18.4604 mL 36.9208 mL 46.151 mL
5 mM 0.3692 mL 1.846 mL 3.6921 mL 7.3842 mL 9.2302 mL
10 mM 0.1846 mL 0.923 mL 1.846 mL 3.6921 mL 4.6151 mL
50 mM 0.0369 mL 0.1846 mL 0.3692 mL 0.7384 mL 0.923 mL
100 mM 0.0185 mL 0.0923 mL 0.1846 mL 0.3692 mL 0.4615 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on 14-Benzoylneoline

Comparative normal/failing rat myocardium cell membrane chromatographic analysis system for screening specific components that counteract doxorubicin-induced heart failure from Acontium carmichaeli.[Pubmed:24731167]

Anal Chem. 2014 May 20;86(10):4748-57.

Cell membrane chromatography (CMC) derived from pathological tissues is ideal for screening specific components acting on specific diseases from complex medicines owing to the maximum simulation of in vivo drug-receptor interactions. However, there are no pathological tissue-derived CMC models that have ever been developed, as well as no visualized affinity comparison of potential active components between normal and pathological CMC columns. In this study, a novel comparative normal/failing rat myocardium CMC analysis system based on online column selection and comprehensive two-dimensional (2D) chromatography/monolithic column/time-of-flight mass spectrometry was developed for parallel comparison of the chromatographic behaviors on both normal and pathological CMC columns, as well as rapid screening of the specific therapeutic agents that counteract doxorubicin (DOX)-induced heart failure from Acontium carmichaeli (Fuzi). In total, 16 potential active alkaloid components with similar structures in Fuzi were retained on both normal and failing myocardium CMC models. Most of them had obvious decreases of affinities on failing myocardium CMC compared with normal CMC model except for four components, talatizamine (TALA), 14-acetyl-TALA, hetisine, and 14-Benzoylneoline. One compound TALA with the highest affinity was isolated for further in vitro pharmacodynamic validation and target identification to validate the screen results. Voltage-dependent K(+) channel was confirmed as a binding target of TALA and 14-acetyl-TALA with high affinities. The online high throughput comparative CMC analysis method is suitable for screening specific active components from herbal medicines by increasing the specificity of screened results and can also be applied to other biological chromatography models.

Keywords:

14-Benzoylneoline,99633-05-3,Natural Products, buy 14-Benzoylneoline , 14-Benzoylneoline supplier , purchase 14-Benzoylneoline , 14-Benzoylneoline cost , 14-Benzoylneoline manufacturer , order 14-Benzoylneoline , high purity 14-Benzoylneoline

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: