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2,5-Dihydroxybenzaldehyde

CAS# 1194-98-5

2,5-Dihydroxybenzaldehyde

Catalog No. BCN6081----Order now to get a substantial discount!

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Quality Control of 2,5-Dihydroxybenzaldehyde

Number of papers citing our products

Chemical structure

2,5-Dihydroxybenzaldehyde

3D structure

Chemical Properties of 2,5-Dihydroxybenzaldehyde

Cas No. 1194-98-5 SDF Download SDF
PubChem ID 70949 Appearance Powder
Formula C7H6O3 M.Wt 138.1
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2,5-dihydroxybenzaldehyde
SMILES C1=CC(=C(C=C1O)C=O)O
Standard InChIKey CLFRCXCBWIQVRN-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2,5-Dihydroxybenzaldehyde

The heartwoods of Pseudolarix amabilis

Biological Activity of 2,5-Dihydroxybenzaldehyde

Description2,5-Dihydroxybenzaldehyde has antioxidant activity.
TargetsAntifection
In vitro

Effect of structure on the interactions between five natural antimicrobial compounds and phospholipids of bacterial cell membrane on model monolayers.[Pubmed: 24914896]

Molecules. 2014 Jun 6;19(6):7497-515.

Monolayers composed of bacterial phospholipids were used as model membranes to study interactions of the naturally occurring phenolic compounds 2,5-Dihydroxybenzaldehyde and 2-hydroxy-5-methoxybenzaldehyde, and the plant essential oil compounds carvacrol, cinnamaldehyde, and geraniol, previously found to be active against both Gram-positive and Gram-negative pathogenic microorganisms.
METHODS AND RESULTS:
The lipid monolayers consist of 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (DPPE), 1,2-dihexa- decanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (DPPG), and 1,1',2,2'-tetratetradecanoyl cardiolipin (cardiolipin). Surface pressure-area (π-A) and surface potential-area (Δψ-A) isotherms were measured to monitor changes in the thermodynamic and physical properties of the lipid monolayers. Results of the study indicated that the five compounds modified the three lipid monolayer structures by integrating into the monolayer, forming aggregates of antimicrobial -lipid complexes, reducing the packing effectiveness of the lipids, increasing the membrane fluidity, and altering the total dipole moment in the monolayer membrane model. The interactions of the five antimicrobial compounds with bacterial phospholipids depended on both the structure of the antimicrobials and the composition of the monolayers.
CONCLUSIONS:
The observed experimental results provide insight into the mechanism of the molecular interactions between naturally-occurring antimicrobial compounds and phospholipids of the bacterial cell membrane that govern activities.

Diffusion-free mediator based miniature biofuel cell anode fabricated on a carbon-MEMS electrode.[Pubmed: 22946444 ]

Langmuir. 2012 Oct 2;28(39):14055-64.

We report on the functionalization of a micropatterned carbon electrode fabricated using the carbon-MEMS process for its use as a miniature diffusion-free glucose oxidase anode.
METHODS AND RESULTS:
Carbon-MEMS based electrodes offer precise manufacturing control on both the micro- and nanoscale and possess higher electron conductivity than redox hydrogels. However, the process involves pyrolysis in a reducing environment that renders the electrode surface less reactive and introduction of a high density of functional groups becomes challenging. Our functionalization strategy involves the electrochemical oxidation of amine linkers onto the electrode. This strategy works well with both aliphatic and aryl linkers and uses stable compounds. The anode is designed to operate through mediated electron transfer between 2,5-Dihydroxybenzaldehyde (DHB) based redox mediator and glucose oxidase enzyme. The electrode was first functionalized with ethylene diamine (EDA) to serve as a linker for the redox mediator. The redox mediator was then grafted through reductive amination, and attachment was confirmed through cyclic voltammetry. The enzyme immobilization was carried out through either adsorption or attachment, and their efficiency was compared. For enzyme attachment, the DHB attached electrode was functionalized again through electro-oxidation of aminobenzoic acid (ABA) linker. The ABA functionalization resulted in reduction of the DHB redox current, perhaps due to increased steric hindrance on the electrode surface, but the mediator function was preserved. Enzyme attachment was then carried out through a coupling reaction between the free carboxyl group on the ABA linker and the amine side chains on the enzyme. The enzyme incubation for both adsorption and attachment was done either through a dry spotting method or wet spotting method. The dry spotting method calls for the evaporation of enzyme droplet to form a thin film before sealing the electrode environment, to increase the effective concentration of the enzyme on the electrode surface during incubation. The electrodes were finally protected with a gelatin based hydrogel film. The anode half-cell was tested using cyclic voltammetry in deoxygenated phosphate buffer saline solution pH 7.4 to minimize oxygen interference and to simulate the pH environment of the body. The electrodes that yielded the highest anodic current were prepared by enzyme attachment method with dry spotting incubation.
CONCLUSIONS:
A polarization response was generated for this anodic half-cell and exhibits operation close to maximum efficiency that is limited by the mass transport of glucose to the electrode.

Protocol of 2,5-Dihydroxybenzaldehyde

Structure Identification
Int J Biol Macromol. 2012 Dec;51(5):1159-66.

Synthesis and characterization of novel nano-chitosan Schiff base and use of lead (II) sensor.[Pubmed: 22982811]

A new kind of nano-chitosan Schiff base ligand (CHNS) with particle size of 34 nm was formed by the reaction between the 2-amino groups of glucosamine residue of nano-chitosan and a 2,5-Dihydroxybenzaldehyde.
METHODS AND RESULTS:
The chemical structures of the nano-chitosan and nano-chitosan Schiff base were characterized by FT-IR spectra, particle sizer, zeta potential, and elemental analysis. A new, simple and effective chemically modified carbon paste electrode with CHNS was prepared and used as a lead (II) sensor. The prepared electrode was characterized using scanning electronic microscopy (SEM-EDX) and cyclic voltammetry (CV). The modified electrode showed only one oxidation peak in the anodic scan at -0.34 V (vs. Ag/AgCl) for the oxidation of lead (II). The dedection limit (LOD) was calculated as 1.36×10(-7) for a 10-min preconcentration time at pH 6.0.

Comptes Rendus Chimie, 2016,20(4): 365-9.

Spectroscopic determination of the dissociation constants of 2,4- and 2,5-dihydroxybenzaldehydes and relationships to their antioxidant activities[Reference: WebLink]


METHODS AND RESULTS:
UV–visible spectra of 2,4-dihydroxybenzaldehyde and 2,5-Dihydroxybenzaldehyde (2,4DHB and 2,5DHB) are recorded in a wide range of pH. The dissociation pK values obtained from these measurements were 6.94 ± 0.03 and 9.28 ± 0.03 for 2,4DHB and 8.42 ± 0.03 and 10.93 ± 0.03 for 2,5DHB.
CONCLUSIONS:
The results indicate that the pH at which the assays for antioxidant capacity measurements are made is very important in light of the hydroxyl group dissociation, because of the different dissociation constants of the different isomers. The percentage of dissociation of each group is essential, the positions of these groups in the ring appearing as a secondary factor.

2,5-Dihydroxybenzaldehyde Dilution Calculator

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Preparing Stock Solutions of 2,5-Dihydroxybenzaldehyde

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 7.2411 mL 36.2056 mL 72.4113 mL 144.8226 mL 181.0282 mL
5 mM 1.4482 mL 7.2411 mL 14.4823 mL 28.9645 mL 36.2056 mL
10 mM 0.7241 mL 3.6206 mL 7.2411 mL 14.4823 mL 18.1028 mL
50 mM 0.1448 mL 0.7241 mL 1.4482 mL 2.8965 mL 3.6206 mL
100 mM 0.0724 mL 0.3621 mL 0.7241 mL 1.4482 mL 1.8103 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2,5-Dihydroxybenzaldehyde

Effect of structure on the interactions between five natural antimicrobial compounds and phospholipids of bacterial cell membrane on model monolayers.[Pubmed:24914896]

Molecules. 2014 Jun 6;19(6):7497-515.

Monolayers composed of bacterial phospholipids were used as model membranes to study interactions of the naturally occurring phenolic compounds 2,5-Dihydroxybenzaldehyde and 2-hydroxy-5-methoxybenzaldehyde, and the plant essential oil compounds carvacrol, cinnamaldehyde, and geraniol, previously found to be active against both Gram-positive and Gram-negative pathogenic microorganisms. The lipid monolayers consist of 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (DPPE), 1,2-dihexa- decanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (DPPG), and 1,1',2,2'-tetratetradecanoyl cardiolipin (cardiolipin). Surface pressure-area (pi-A) and surface potential-area (Deltapsi-A) isotherms were measured to monitor changes in the thermodynamic and physical properties of the lipid monolayers. Results of the study indicated that the five compounds modified the three lipid monolayer structures by integrating into the monolayer, forming aggregates of antimicrobial -lipid complexes, reducing the packing effectiveness of the lipids, increasing the membrane fluidity, and altering the total dipole moment in the monolayer membrane model. The interactions of the five antimicrobial compounds with bacterial phospholipids depended on both the structure of the antimicrobials and the composition of the monolayers. The observed experimental results provide insight into the mechanism of the molecular interactions between naturally-occurring antimicrobial compounds and phospholipids of the bacterial cell membrane that govern activities.

Diffusion-free mediator based miniature biofuel cell anode fabricated on a carbon-MEMS electrode.[Pubmed:22946444]

Langmuir. 2012 Oct 2;28(39):14055-64.

We report on the functionalization of a micropatterned carbon electrode fabricated using the carbon-MEMS process for its use as a miniature diffusion-free glucose oxidase anode. Carbon-MEMS based electrodes offer precise manufacturing control on both the micro- and nanoscale and possess higher electron conductivity than redox hydrogels. However, the process involves pyrolysis in a reducing environment that renders the electrode surface less reactive and introduction of a high density of functional groups becomes challenging. Our functionalization strategy involves the electrochemical oxidation of amine linkers onto the electrode. This strategy works well with both aliphatic and aryl linkers and uses stable compounds. The anode is designed to operate through mediated electron transfer between 2,5-Dihydroxybenzaldehyde (DHB) based redox mediator and glucose oxidase enzyme. The electrode was first functionalized with ethylene diamine (EDA) to serve as a linker for the redox mediator. The redox mediator was then grafted through reductive amination, and attachment was confirmed through cyclic voltammetry. The enzyme immobilization was carried out through either adsorption or attachment, and their efficiency was compared. For enzyme attachment, the DHB attached electrode was functionalized again through electro-oxidation of aminobenzoic acid (ABA) linker. The ABA functionalization resulted in reduction of the DHB redox current, perhaps due to increased steric hindrance on the electrode surface, but the mediator function was preserved. Enzyme attachment was then carried out through a coupling reaction between the free carboxyl group on the ABA linker and the amine side chains on the enzyme. The enzyme incubation for both adsorption and attachment was done either through a dry spotting method or wet spotting method. The dry spotting method calls for the evaporation of enzyme droplet to form a thin film before sealing the electrode environment, to increase the effective concentration of the enzyme on the electrode surface during incubation. The electrodes were finally protected with a gelatin based hydrogel film. The anode half-cell was tested using cyclic voltammetry in deoxygenated phosphate buffer saline solution pH 7.4 to minimize oxygen interference and to simulate the pH environment of the body. The electrodes that yielded the highest anodic current were prepared by enzyme attachment method with dry spotting incubation. A polarization response was generated for this anodic half-cell and exhibits operation close to maximum efficiency that is limited by the mass transport of glucose to the electrode.

A bioanode based on MWCNT/protein-assisted co-immobilization of glucose oxidase and 2,5-dihydroxybenzaldehyde for glucose fuel cells.[Pubmed:20472420]

Biosens Bioelectron. 2010 Jul 15;25(11):2515-21.

This paper describes an easy-to-prepare, robust bioanode constructed on a polyester-supported screen-printed carbon paste electrode (SPCE) for glucose biofuel cells. To prepare the bioanode, carboxylated multi-walled carbon nanotubes (MWCNTs) were drop-coated on the SPCE first, and then a crosslinked matrix composed of glucose oxidase (GOx), 2,5-Dihydroxybenzaldehyde (DHB), bovine serum albumin (BSA) and glutaraldehyde was coated atop the MWCNTs. It was found that the MWCNTs assisted the immobilization of the crosslinked matrix, enhanced the electron-shuttling process, and showed electrocatalytic effect to gluconic acid, which allowed squeeze more electrons out of a glucose molecule. Inside the matrix, DHB mediators could couple to GOx and BSA via the Schiff base reaction, and GOx and BSA could crosslink to each other with glutaraldehyde. From cyclic voltammetry, it was estimated that 3.63 nmol cm(-2) of DHB was anchored on the bioanode, and no mediator leaching was observed. The bioanode also attained reproducible flow-injection analysis (FIA) signals for glucose sensing (RSD=4.99%) and retained 84% of the initial response after keeping in a buffer at 4 degrees C for a week. In addition, the bioanode obeyed the Michaelis-Menten kinetics. Finally, we demonstrated that a glucose biofuel cell assembled with an optimal bioanode and a laccase/ABTS cathode generated an electric power of 45 microW cm(-2) from 1M glucose at 37 degrees C.

Synthesis and characterization of novel nano-chitosan Schiff base and use of lead (II) sensor.[Pubmed:22982811]

Int J Biol Macromol. 2012 Dec;51(5):1159-66.

A new kind of nano-chitosan Schiff base ligand (CHNS) with particle size of 34 nm was formed by the reaction between the 2-amino groups of glucosamine residue of nano-chitosan and a 2,5-Dihydroxybenzaldehyde. The chemical structures of the nano-chitosan and nano-chitosan Schiff base were characterized by FT-IR spectra, particle sizer, zeta potential, and elemental analysis. A new, simple and effective chemically modified carbon paste electrode with CHNS was prepared and used as a lead (II) sensor. The prepared electrode was characterized using scanning electronic microscopy (SEM-EDX) and cyclic voltammetry (CV). The modified electrode showed only one oxidation peak in the anodic scan at -0.34 V (vs. Ag/AgCl) for the oxidation of lead (II). The dedection limit (LOD) was calculated as 1.36x10(-7) for a 10-min preconcentration time at pH 6.0.

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