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2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

CAS# 176983-21-4

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Catalog No. BCN7406----Order now to get a substantial discount!

Product Name & Size Price Stock
2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid: 5mg $828 In Stock
2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid: 10mg Please Inquire In Stock
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Quality Control of 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

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Chemical structure

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

3D structure

Chemical Properties of 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Cas No. 176983-21-4 SDF Download SDF
PubChem ID 637229 Appearance Powder
Formula C30H46O5 M.Wt 486.69
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,2R,4aS,6aR,6aS,6bR,8aR,11R,12aR,14bS)-1,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-oxo-3,4,5,6,6a,7,8,8a,11,12,13,14b-dodecahydro-2H-picene-4a-carboxylic acid
SMILES CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(=O)C5(C)C)O)C)C)C2C1(C)O)C)C(=O)O
Standard InChIKey LJORXTIGOHMBOS-OTRVPSFMSA-N
Standard InChI InChI=1S/C30H46O5/c1-17-10-13-30(24(33)34)15-14-27(5)18(22(30)29(17,7)35)8-9-21-26(4)16-19(31)23(32)25(2,3)20(26)11-12-28(21,27)6/h8,17,19-22,31,35H,9-16H2,1-7H3,(H,33,34)/t17-,19-,20+,21-,22-,26+,27-,28-,29-,30+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

The leaves of Eriobotrya japonica.

Biological Activity of 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Description1. 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. 2. 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay of two-stage carcinogenesis on mouse skin.
TargetsHIV

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid Dilution Calculator

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2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid Molarity Calculator

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Preparing Stock Solutions of 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0547 mL 10.2735 mL 20.547 mL 41.0939 mL 51.3674 mL
5 mM 0.4109 mL 2.0547 mL 4.1094 mL 8.2188 mL 10.2735 mL
10 mM 0.2055 mL 1.0273 mL 2.0547 mL 4.1094 mL 5.1367 mL
50 mM 0.0411 mL 0.2055 mL 0.4109 mL 0.8219 mL 1.0273 mL
100 mM 0.0205 mL 0.1027 mL 0.2055 mL 0.4109 mL 0.5137 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Production of bioactive triterpenes by Eriobotrya japonica calli.[Pubmed:11830140]

Phytochemistry. 2002 Feb;59(3):315-23.

Callus tissue cultures induced from an axenic leaf of Eriobotrya japonica (Rosaceae) produced triterpenes in large amounts (ca. 50 mg/g dry wt). Nine triterpenes were characterized as ursolic acid, oleanolic acid, 2alpha-hydoxyursolic acid, maslinic acid, tormentic acid, 2alpha, 19alpha-dihydroxy-3-oxo-urs-12-en-28-oic acid, hyptadienic acid and a mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid. The triterpene composition in the callus tissues was noticeably different from that in intact leaves. The contents of tormentic acid with antidiabetic action, and 2alpha, 19alpha-dihydroxy-3-oxo-urs-12-en-28-oic acid with anti-HIV activity, were much larger than those in the intact leaves. All of the triterpenes isolated from the callus tissues showed an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 2alpha, 19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid was the most potent inhibitor among them and caused a significant delay of two-stage carcinogenesis on mouse skin.

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