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3-(2,4-Dihydroxyphenyl)propionic acid

CAS# 5631-68-5

3-(2,4-Dihydroxyphenyl)propionic acid

Catalog No. BCN5751----Order now to get a substantial discount!

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3-(2,4-Dihydroxyphenyl)propionic acid: 5mg $23 In Stock
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Quality Control of 3-(2,4-Dihydroxyphenyl)propionic acid

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Chemical structure

3-(2,4-Dihydroxyphenyl)propionic acid

3D structure

Chemical Properties of 3-(2,4-Dihydroxyphenyl)propionic acid

Cas No. 5631-68-5 SDF Download SDF
PubChem ID 96384 Appearance Powder
Formula C9H10O4 M.Wt 182.2
Type of Compound Phenylpropanoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-(2,4-dihydroxyphenyl)propanoic acid
SMILES C1=CC(=C(C=C1O)O)CCC(=O)O
Standard InChIKey HMCMTJPPXSGYJY-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3-(2,4-Dihydroxyphenyl)propionic acid

The herbs of Juniperus formosana

Biological Activity of 3-(2,4-Dihydroxyphenyl)propionic acid

Description3-(2,4-Dihydroxyphenyl)propionic acid and l-ascorbic acid show tyrosinase inhibition activity, a synergistic effect on tyrosinase inhibition was observed when the two compounds were mixed.
TargetsTyrosinase
In vitro

Prevention of Agaricus bisporus postharvest browning with tyrosinase inhibitors[Reference: WebLink]

Postharvest Biology and Technology, 2006,39(3):272-7.

Postharvest browning of Agaricus bisporus mushrooms is a severe problem that reduces the shelf life of harvested mushrooms. Mushroom browning occurs mainly as a result of tyrosinase activity, an enzyme belonging to the polyphenol oxidase (PPO) family and known to be a key enzyme in melanin biosynthesis.
METHODS AND RESULTS:
An ethanolic extract from licorice roots (Glycyrrhiza glabra) and [3-(2,4-Dihydroxyphenyl)propionic acid] (DPPacid) isolated from fig leaves and fruit have been shown to inhibit tyrosinase activity. Adding these inhibitors to sliced mushrooms had a very strong inhibitory effect on browning, but pre-storage immersion of intact mushroom in the licorice extract did not prevent browning after 8 days storage at 4 °C. By contrast, treatment with DPPacid at 1 μg/mL reduced browning by half. Measurement of inhibitor uptake by mass spectra (MS) and assay of tyrosinase activity indicated that penetration into the mushroom tissue was inadequate for tyrosinase inhibition. Moreover, DPPacid was found to be unstable in the mushroom tissue and within a short time it was, presumably, metabolised.

Protocol of 3-(2,4-Dihydroxyphenyl)propionic acid

Kinase Assay

The evaluation of the synergistic effect of 3-(2,4-dihydroxyphenyl)propionic acid and l-ascorbic acid on tyrosinase inhibition.[Pubmed: 27442367 ]

Z Naturforsch C. 2017 Mar 1;72(3-4):119-121.

3-(2,4-Dihydroxyphenyl)propionic acid (DDPA) and l-ascorbic acid (vitamin C) show tyrosinase inhibition activity. A synergistic effect on tyrosinase inhibition was observed when the two compounds were mixed. The effect significantly decreased the IC50 value of both compounds.

3-(2,4-Dihydroxyphenyl)propionic acid Dilution Calculator

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3-(2,4-Dihydroxyphenyl)propionic acid Molarity Calculator

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Preparing Stock Solutions of 3-(2,4-Dihydroxyphenyl)propionic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.4885 mL 27.4424 mL 54.8847 mL 109.7695 mL 137.2119 mL
5 mM 1.0977 mL 5.4885 mL 10.9769 mL 21.9539 mL 27.4424 mL
10 mM 0.5488 mL 2.7442 mL 5.4885 mL 10.9769 mL 13.7212 mL
50 mM 0.1098 mL 0.5488 mL 1.0977 mL 2.1954 mL 2.7442 mL
100 mM 0.0549 mL 0.2744 mL 0.5488 mL 1.0977 mL 1.3721 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3-(2,4-Dihydroxyphenyl)propionic acid

The evaluation of the synergistic effect of 3-(2,4-dihydroxyphenyl)propionic acid and l-ascorbic acid on tyrosinase inhibition.[Pubmed:27442367]

Z Naturforsch C. 2017 Mar 1;72(3-4):119-121.

3-(2,4-Dihydroxyphenyl)propionic acid (DDPA) and l-ascorbic acid (vitamin C) show tyrosinase inhibition activity. A synergistic effect on tyrosinase inhibition was observed when the two compounds were mixed. The effect significantly decreased the IC50 value of both compounds.

Description

3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC50 and a Ki of 3.02 μM and 11.5 μM, respectively.

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