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3,4,5-Tri-O-galloylquinic acid

CAS# 99745-62-7

3,4,5-Tri-O-galloylquinic acid

Catalog No. BCN8027----Order now to get a substantial discount!

Product Name & Size Price Stock
3,4,5-Tri-O-galloylquinic acid: 5mg Please Inquire In Stock
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Quality Control of 3,4,5-Tri-O-galloylquinic acid

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Chemical structure

3,4,5-Tri-O-galloylquinic acid

3D structure

Chemical Properties of 3,4,5-Tri-O-galloylquinic acid

Cas No. 99745-62-7 SDF Download SDF
PubChem ID 127406 Appearance Powder
Formula C28H24O18 M.Wt 648.48
Type of Compound Phenylpropanoids Storage Desiccate at -20°C
Synonyms (3r,5r)-1-hydroxy-3,4,5-tris[(3,4,5-trihydroxybenzoyl)oxy]cyclohexanecarboxylic acid
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3R,5R)-1-hydroxy-3,4,5-tris[(3,4,5-trihydroxybenzoyl)oxy]cyclohexane-1-carboxylic acid
SMILES C1C(C(C(CC1(C(=O)O)O)OC(=O)C2=CC(=C(C(=C2)O)O)O)OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Standard InChIKey PEOHIPMSHPWYAQ-IOALSNHGSA-N
Standard InChI InChI=1S/C28H24O18/c29-12-1-9(2-13(30)20(12)35)24(38)44-18-7-28(43,27(41)42)8-19(45-25(39)10-3-14(31)21(36)15(32)4-10)23(18)46-26(40)11-5-16(33)22(37)17(34)6-11/h1-6,18-19,23,29-37,43H,7-8H2,(H,41,42)/t18-,19-,23?,28?/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3,4,5-Tri-O-galloylquinic acid

The herbs of Lonicera japonica

Biological Activity of 3,4,5-Tri-O-galloylquinic acid

Description1. 3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
TargetsTNF-α | IL Receptor | JNK | Caspase | p38MAPK | Histamine Receptor

3,4,5-Tri-O-galloylquinic acid Dilution Calculator

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3,4,5-Tri-O-galloylquinic acid Molarity Calculator

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Preparing Stock Solutions of 3,4,5-Tri-O-galloylquinic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5421 mL 7.7103 mL 15.4207 mL 30.8414 mL 38.5517 mL
5 mM 0.3084 mL 1.5421 mL 3.0841 mL 6.1683 mL 7.7103 mL
10 mM 0.1542 mL 0.771 mL 1.5421 mL 3.0841 mL 3.8552 mL
50 mM 0.0308 mL 0.1542 mL 0.3084 mL 0.6168 mL 0.771 mL
100 mM 0.0154 mL 0.0771 mL 0.1542 mL 0.3084 mL 0.3855 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3,4,5-Tri-O-galloylquinic acid

Therapeutic effects of Artemisia scoparia Waldst. et Kitaib in a murine model of atopic dermatitis.[Pubmed:29740850]

Clin Exp Dermatol. 2018 Oct;43(7):798-805.

BACKGROUND: Artemisia scoparia Waldst. et Kitaib (AS) (Oriental wormwood, known as Bissuk in Korea) is a plant used in cosmetic and pharmaceutical treatments. However, the effect of AS on atopic dermatitis (AD) has not been described. AIM: To examine the inhibitory effect of AS on AD using a murine model. METHODS: We applied either AS, the butanol-extracted fraction of AS (Bu-OH) or 3,5-dicaffeoyl-epi-quinic acid (DEQA, a major component of Bu-OH) topically for 3 weeks to 2,4-dinitrofluorobenzene (DNFB)-induced skin lesions in BALB/c mice. RESULTS: AS, Bu-OH and DEQA suppressed the clinical symptoms of DNFB-induced skin lesions and he associated scratching behaviour. Numbers of inflammatory cells infiltrating skin lesions were significantly reduced by AS or Bu-OH application but not by DEQA. In addition, AS significantly suppressed serum levels of histamine and IgE, while Bu-OH significantly suppressed serum levels of histamine, IgE, thymic stromal lymphopoietin (TSLP), interleukin (IL)-4 and IL-6, and DEQA significantly suppressed serum levels of histamine, IgE, TSLP and IL-4 in DNFB-induced AD mice. In skin lesions, AS and Bu-OH significantly reduced inflammatory cytokines, whereas DEQA did not. AS, Bu-OH and DEQA all significantly suppressed caspase-1 activities. CONCLUSIONS: These results demonstrate the anti-AD effects of AS, Bu-OH and DEQA, and suggest that all three have therapeutic potential.

Anti-inflammatory effects of Artemisia scoparia and its active constituent, 3,5-dicaffeoyl-epi-quinic acid against activated mast cells.[Pubmed:29172841]

Immunopharmacol Immunotoxicol. 2018 Feb;40(1):52-58.

OBJECTIVES: Artemisia scoparia Waldst. et Kit. (AS) has been used to treat inflammation, urticaria and hepatitis. However, the scientific studies of AS and its active compound for inflammatory reactions in activated human mast cell line, HMC-1 cells have not yet been elucidated. MATERIALS AND METHODS: Here, we isolated 3,5-dicaffeoyl-epi-quinic acid (DEQA) from AS butanol fraction. The anti-inflammatory effect of AS and its new active compound, DEQA was examined in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced thymic stromal lymphopoietin (TSLP), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion and mRNA expression by ELISA and RT-PCR, respectively. Furthermore, mechanism related to anti-inflammatory was examined by Western blotting. RESULTS: We reported that AS and its new active compound, DEQA significantly reduced TSLP, TNF-alpha, IL-1beta and IL-6 production levels through the reduction of caspase-1 activity. The mRNA expression of these inflammatory cytokine was also reduced via blocking nuclear factor-kappaB nuclear translocation by AS and DEQA. In addition, AS significantly reduced phosphorylated-c-Jun N-terminal kinase level and DEQA significantly reduced both phosphorylated-c-Jun N-terminal kinase and -p38 mitogen-activated protein kinase levels. CONCLUSIONS: Therefore, these results indicated that AS and its active compound, DEQA may improve mast cell-mediated inflammatory diseases.

Keywords:

3,4,5-Tri-O-galloylquinic acid,99745-62-7,(3r,5r)-1-hydroxy-3,4,5-tris[(3,4,5-trihydroxybenzoyl)oxy]cyclohexanecarboxylic acid,Natural Products, buy 3,4,5-Tri-O-galloylquinic acid , 3,4,5-Tri-O-galloylquinic acid supplier , purchase 3,4,5-Tri-O-galloylquinic acid , 3,4,5-Tri-O-galloylquinic acid cost , 3,4,5-Tri-O-galloylquinic acid manufacturer , order 3,4,5-Tri-O-galloylquinic acid , high purity 3,4,5-Tri-O-galloylquinic acid

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