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5-Aminoisoquinoline

CAS# 1125-60-6

5-Aminoisoquinoline

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Product Name & Size Price Stock
5-Aminoisoquinoline: 5mg $17 In Stock
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Quality Control of 5-Aminoisoquinoline

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Chemical structure

5-Aminoisoquinoline

3D structure

Chemical Properties of 5-Aminoisoquinoline

Cas No. 1125-60-6 SDF Download SDF
PubChem ID 70766 Appearance Powder
Formula C9H8N2 M.Wt 144
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name isoquinolin-5-amine
SMILES C1=CC2=C(C=CN=C2)C(=C1)N
Standard InChIKey DTVYNUOOZIKEEX-UHFFFAOYSA-N
Standard InChI InChI=1S/C9H8N2/c10-9-3-1-2-7-6-11-5-4-8(7)9/h1-6H,10H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

5-Aminoisoquinoline Dilution Calculator

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5-Aminoisoquinoline Molarity Calculator

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Preparing Stock Solutions of 5-Aminoisoquinoline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.9444 mL 34.7222 mL 69.4444 mL 138.8889 mL 173.6111 mL
5 mM 1.3889 mL 6.9444 mL 13.8889 mL 27.7778 mL 34.7222 mL
10 mM 0.6944 mL 3.4722 mL 6.9444 mL 13.8889 mL 17.3611 mL
50 mM 0.1389 mL 0.6944 mL 1.3889 mL 2.7778 mL 3.4722 mL
100 mM 0.0694 mL 0.3472 mL 0.6944 mL 1.3889 mL 1.7361 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5-Aminoisoquinoline

Possible role of poly(ADP-ribose) polymerase in pathological and physiological cardiac hypertrophy.[Pubmed:17235412]

Methods Find Exp Clin Pharmacol. 2006 Dec;28(10):683-9.

The present study was designed to investigate the effect of 5-Aminoisoquinoline, a specific poly(ADP-ribose) polymerase (PARP) inhibitor, in partial abdominal aortic constriction (PAAC) for 4 weeks it induced pathological and chronic swimming training (CST) for 8 weeks it induced physiological cardiac hypertrophy. 5-Aminoisoquinoline (0.3 mg/kg/day and 3 mg/kg/day, i.p.) treatment was started 3 days before PAAC and CST, and it was continued for 4 weeks after PAAC and 8 weeks after initiation of CST. The left ventricular (LV) function and LV hypertrophy were assessed by measuring LVDP, dp/dtmax, dp/dtmin, ratio of LV weight to body weight (LVW/BW), LV wall thickness (LVWT), LV collagen content, LV protein content, and LV RNA concentration. Further, venous pressure (VP) and mean arterial blood pressure (MABP) were recorded. The PAAC, but not CST, produced LV dysfunction by decreasing LVDP, dp/dtmax, dp/dtmin, and increasing LV collagen content. Further, PAAC and CST were noted to produce LV hypertrophy by increasing LVW/BW, LVWT, LV protein content, and LV RNA concentration. Moreover, in contrast to CST, PAAC significantly increased VP and MABP. The 5-Aminoisoquinoline, a potent selective inhibitor of PARP, significantly attenuated PAAC-induced LV dysfunction, LV hypertrophy, increase in VP and MABP. On the other hand, treatment with 5-Aminoisoquinoline did not modulate CST-induced physiological cardiac hypertrophy. These results implicate PARP in PAAC-induced LV dysfunction and pathological cardiac hypertrophy. However, PARP may not be involved in CST-induced physiological cardiac hypertrophy.

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