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5-Chlorothiophene-2-carboxylic acid

CAS# 24065-33-6

5-Chlorothiophene-2-carboxylic acid

Catalog No. BCC8745----Order now to get a substantial discount!

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5-Chlorothiophene-2-carboxylic acid: 5mg $17 In Stock
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Chemical structure

5-Chlorothiophene-2-carboxylic acid

3D structure

Chemical Properties of 5-Chlorothiophene-2-carboxylic acid

Cas No. 24065-33-6 SDF Download SDF
PubChem ID 95048 Appearance Powder
Formula C5H3ClO2S M.Wt 162.6
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-chlorothiophene-2-carboxylic acid
SMILES C1=C(SC(=C1)Cl)C(=O)O
Standard InChIKey QZLSBOVWPHXCLT-UHFFFAOYSA-N
Standard InChI InChI=1S/C5H3ClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

5-Chlorothiophene-2-carboxylic acid Dilution Calculator

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5-Chlorothiophene-2-carboxylic acid Molarity Calculator

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Preparing Stock Solutions of 5-Chlorothiophene-2-carboxylic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.1501 mL 30.7503 mL 61.5006 mL 123.0012 mL 153.7515 mL
5 mM 1.23 mL 6.1501 mL 12.3001 mL 24.6002 mL 30.7503 mL
10 mM 0.615 mL 3.075 mL 6.1501 mL 12.3001 mL 15.3752 mL
50 mM 0.123 mL 0.615 mL 1.23 mL 2.46 mL 3.075 mL
100 mM 0.0615 mL 0.3075 mL 0.615 mL 1.23 mL 1.5375 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5-Chlorothiophene-2-carboxylic acid

5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperaz in-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.[Pubmed:24175584]

J Med Chem. 2013 Dec 12;56(23):9441-56.

Compound 15 (SAR107375), a novel potent dual thrombin and factor Xa inhibitor resulted from a rational optimization process. Starting from compound 14, with low factor Xa and modest anti-thrombin inhibitory activities (IC50's of 3.5 and 0.39 muM, respectively), both activities were considerably improved, notably through the incorporation of a neutral chlorothiophene P1 fragment and tuning of P2 and P3-P4 fragments. Final optimization of metabolic stability with microsomes led to the identification of 15, which displays strong activity in vitro vs factor Xa and thrombin (with Ki's of 1 and 8 nM, respectively). In addition 15 presents good selectivity versus related serine proteases (roughly 300-fold), including trypsin (1000-fold), and is very active (0.39 muM) in the thrombin generation time (TGT) coagulation assay in human platelet rich plasma (PRP). Potent in vivo activity in a rat model of venous thrombosis following iv and, more importantly, po administration was also observed (ED50 of 0.07 and 2.8 mg/kg, respectively). Bleeding liability was reduced in the rat wire coil model, more relevant to arterial thrombosis, with 15 (blood loss increase of 2-fold relative to the ED80 value) compared to rivaroxaban 2 and dabigatran etexilate 1a.

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