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7alpha-Hydroxystigmasterol

CAS# 64998-19-2

7alpha-Hydroxystigmasterol

Catalog No. BCN4194----Order now to get a substantial discount!

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Quality Control of 7alpha-Hydroxystigmasterol

Number of papers citing our products

Chemical structure

7alpha-Hydroxystigmasterol

3D structure

Chemical Properties of 7alpha-Hydroxystigmasterol

Cas No. 64998-19-2 SDF Download SDF
PubChem ID 21769896 Appearance Powder
Formula C29H48O2 M.Wt 428.7
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3S,7S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
SMILES CCC(C=CC(C)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C)C(C)C
Standard InChIKey DPNNWDOFSGOYEK-KQASBSEXSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7alpha-Hydroxystigmasterol

The herbs of Xanthium sibiricum

Biological Activity of 7alpha-Hydroxystigmasterol

DescriptionStandard reference
In vitro

Two new epoxysteroids from Helianthus tuberosus.[Pubmed: 21996718]

Molecules. 2011 Oct 13;16(10):8646-53.


METHODS AND RESULTS:
Two new epoxy steroids, 5α,8α-epidioxy-22β,23β-epoxyergosta-6-en-3β-ol (1) and 5α,8α-epidioxy-22α,23α-epoxyergosta-6-en-3β-ol (2), and ten known steroids including (24R)-5α,8α-epidioxyergosta-6-en-3β-ol (3), (22E,24R)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (4), (22E,24R)-5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol (5), β-sitosterol (6), sitost-5-en-3β-ol acetate (7), 7alpha-hydroxysitosterol (8), schleicheol 2 (9), (24R)-24-ethyl-5α-cholestane-3β,5α,6β-triol (10), 7alpha-Hydroxystigmasterol (11), and stigmasterol (12) were isolated from Helianthus tuberosus grown in Laizhou salinized land of coastal zone of Bohai Sea, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques.
CONCLUSIONS:
The new compounds 1 and 2 exhibited weak antibacterial activity and no antifungal activity.

Protocol of 7alpha-Hydroxystigmasterol

Structure Identification
Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1370-9.

Studies on Nepalese crude drugs. XXIX. Chemical constituents of Dronapuspi, the whole herb of Leucas cephalotes SPRENG.[Pubmed: 17015972]


METHODS AND RESULTS:
From the whole herb of Leucas cephalotes SPRENG., new labdane-, norlabdane- and abietane-type diterpenes named leucasdins A (1), B (2) and C (3), respectively, and two protostane-type triterpenes named leucastrins A (4) and B (5) were isolated, together with a known triterpene, oleanolic acid, five sterols, 7-oxositosterol, 7-oxostigmasterol, 7alpha-hydroxysitosterol, 7alpha-Hydroxystigmasterol and stigmasterol, and eight flavones, 5-hydroxy-7,4'-dimethoxyflavone, pillion, gonzalitosin I, tricin, cosmosin, apigenin 7-O-beta-D-(6-O-p-coumaroyl)glucopyranoside, anisofolin A and luteolin 4'-O-beta-D-glucuronopyranoside.
CONCLUSIONS:
The structures of 1--5 were determined as (3S,6R,8R,9R,13S,16S)-9,13,15,16-bisepoxy-3,16-diacetoxy-6-formyloxylabdane, (3S,6R)-3-acetoxy-6-formyloxy-iso-ambreinolide, (4R,9S,12R,13R)-12,13-dihydroxyabiet-7-en-18-oic acid, (3S,17S,20S,24S)-3,20-dihydroxy-24-methylprotost-25-en, and (3S,17S,20S,24S)-3,20,24-trihydroxyprotost-25-en respectively, based on spectral and chemical data.

7alpha-Hydroxystigmasterol Dilution Calculator

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7alpha-Hydroxystigmasterol Molarity Calculator

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Preparing Stock Solutions of 7alpha-Hydroxystigmasterol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3326 mL 11.6632 mL 23.3263 mL 46.6527 mL 58.3158 mL
5 mM 0.4665 mL 2.3326 mL 4.6653 mL 9.3305 mL 11.6632 mL
10 mM 0.2333 mL 1.1663 mL 2.3326 mL 4.6653 mL 5.8316 mL
50 mM 0.0467 mL 0.2333 mL 0.4665 mL 0.9331 mL 1.1663 mL
100 mM 0.0233 mL 0.1166 mL 0.2333 mL 0.4665 mL 0.5832 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 7alpha-Hydroxystigmasterol

Two new epoxysteroids from Helianthus tuberosus.[Pubmed:21996718]

Molecules. 2011 Oct 13;16(10):8646-53.

Two new epoxy steroids, 5alpha,8alpha-epidioxy-22beta,23beta-epoxyergosta-6-en-3beta-ol (1) and 5alpha,8alpha-epidioxy-22alpha,23alpha-epoxyergosta-6-en-3beta-ol (2), and ten known steroids including (24R)-5alpha,8alpha-epidioxyergosta-6-en-3beta-ol (3), (22E,24R)-5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (4), (22E,24R)-5alpha,8alpha-epidioxyergosta-6,9(11),22-trien-3beta-ol (5), beta-sitosterol (6), sitost-5-en-3beta-ol acetate (7), 7alpha-hydroxysitosterol (8), schleicheol 2 (9), (24R)-24-ethyl-5alpha-cholestane-3beta,5alpha,6beta-triol (10), 7alpha-Hydroxystigmasterol (11), and stigmasterol (12) were isolated from Helianthus tuberosus grown in Laizhou salinized land of coastal zone of Bohai Sea, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques. The new compounds 1 and 2 exhibited weak antibacterial activity and no antifungal activity.

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