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8alpha-Acetoxyarglabin

CAS# 126829-70-7

8alpha-Acetoxyarglabin

Catalog No. BCN7315----Order now to get a substantial discount!

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Quality Control of 8alpha-Acetoxyarglabin

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Chemical structure

8alpha-Acetoxyarglabin

3D structure

Chemical Properties of 8alpha-Acetoxyarglabin

Cas No. 126829-70-7 SDF Download SDF
PubChem ID 14466131 Appearance Powder
Formula C17H20O5 M.Wt 304.34
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1R,3S,5S,6R,10S,11R)-3,12-dimethyl-7-methylidene-8-oxo-2,9-dioxatetracyclo[9.3.0.01,3.06,10]tetradec-12-en-5-yl] acetate
SMILES CC1=CCC23C1C4C(C(CC2(O3)C)OC(=O)C)C(=C)C(=O)O4
Standard InChIKey CWDIWDKHXGYAMS-URCHBCGGSA-N
Standard InChI InChI=1S/C17H20O5/c1-8-5-6-17-13(8)14-12(9(2)15(19)21-14)11(20-10(3)18)7-16(17,4)22-17/h5,11-14H,2,6-7H2,1,3-4H3/t11-,12+,13+,14-,16-,17+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 8alpha-Acetoxyarglabin

The aerial parts of Artemisia Myriantha Wall.Ex Bess.

Biological Activity of 8alpha-Acetoxyarglabin

Description8alpha-Acetoxyarglabin is a natural product from Artemisia Myriantha Wall.Ex Bess.

Protocol of 8alpha-Acetoxyarglabin

Structure Identification
Chinese Journal of Modern Applied Pharmacy, 2014, 31(6):706-710.

Study on the Chemical Constituents of Artemisia Myriantha Wall.Ex Bess.[Reference: WebLink]

To study the chemical constituents of Artemisia myriantha Wall.ex Bess..
METHODS AND RESULTS:
Silica gel column,Sephadex LH-20 column chromatography were used for separation and purification of the compounds and extensive spectral analysis spectrum were employed for structural elucidation. Eleven compounds were isolated and identified as arglabin(1),13-acetoxy-3β-hydroxyl-germacra-1(10)E,4E,7(11)-trine-12,6α-olide(2),eupatorin(3),8alpha-Acetoxyarglabin(4),artemyriantholide B(5),artemyriantholide A(6),4',5,7-trihydroxy-6,3'-dimethoxy flavone(7),casticin(8),5,4'-dihydroxy-6,7,3',5'-tetramethoxy flavone(9),arborescin(10),arlatin(11).
CONCLUSIONS:
Compounds 3,7~11 are isolated from genus for the first time.

8alpha-Acetoxyarglabin Dilution Calculator

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Preparing Stock Solutions of 8alpha-Acetoxyarglabin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2858 mL 16.429 mL 32.858 mL 65.716 mL 82.145 mL
5 mM 0.6572 mL 3.2858 mL 6.5716 mL 13.1432 mL 16.429 mL
10 mM 0.3286 mL 1.6429 mL 3.2858 mL 6.5716 mL 8.2145 mL
50 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.3143 mL 1.6429 mL
100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6572 mL 0.8214 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 8alpha-Acetoxyarglabin

[Guaianolides from aerial parts of Artemisia myriantha].[Pubmed:29945382]

Zhongguo Zhong Yao Za Zhi. 2018 Jun;43(11):2295-2299.

This study was performed to investigate the guaianolides from the aerial parts of Artemisia myriantha. The chemical constituents were isolated by chromatographic columns over silica gel, Sephadex LH-20, and ODS, as well as Semi-prep HPLC methods, and their structures were identified by NMR and MS data. Ten compounds were isolated and identified as follows: artemyriantholide E (1), tanaphillin (2), 1beta, 10beta-epoxydehydroleucodin (3), 5-hydroxyleucodin (4), dehydrocostuslactone (5), 3-O-methyl-iso-secotanapartholide (6), roxbughianin A (7), dehydroleucodin (8), arglabin (9), and 8alpha-Acetoxyarglabin (10). Compound 1 was a new compound, and compounds 2-7 were isolated from this plant for the first time. Compound 3 exhibited selective cytotoxicity against human liver cancer (Bel-7402) with IC(5)(0) value of 5.35 mumol.L(-)(1), and 6 against human gastric cancer (BGC-823) with IC(5)(0) value of 2.68 mumol.L(-)(1), respectively.

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