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Altretamine hydrochloride

CAS# 2975-00-0

Altretamine hydrochloride

Catalog No. BCC4114----Order now to get a substantial discount!

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Chemical structure

Altretamine hydrochloride

3D structure

Chemical Properties of Altretamine hydrochloride

Cas No. 2975-00-0 SDF Download SDF
PubChem ID 165057 Appearance Powder
Formula C9H19ClN6 M.Wt 246.74
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine;hydrochloride
SMILES CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C.Cl
Standard InChIKey AKAQBNIEQUSIJL-UHFFFAOYSA-N
Standard InChI InChI=1S/C9H18N6.ClH/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6;/h1-6H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Altretamine hydrochloride Dilution Calculator

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Altretamine hydrochloride Molarity Calculator

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Preparing Stock Solutions of Altretamine hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.0528 mL 20.2642 mL 40.5285 mL 81.057 mL 101.3212 mL
5 mM 0.8106 mL 4.0528 mL 8.1057 mL 16.2114 mL 20.2642 mL
10 mM 0.4053 mL 2.0264 mL 4.0528 mL 8.1057 mL 10.1321 mL
50 mM 0.0811 mL 0.4053 mL 0.8106 mL 1.6211 mL 2.0264 mL
100 mM 0.0405 mL 0.2026 mL 0.4053 mL 0.8106 mL 1.0132 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Altretamine hydrochloride

Altretamine is an alkylating agent proposed as an antineoplastic.

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References on Altretamine hydrochloride

Doxorubicin-hexamethylmelamine therapy of small cell carcinoma of the lung.[Pubmed:6271385]

Cancer. 1981 Nov 1;48(9):1944-6.

Eighteen patients with small cell carcinoma of the lung treated with doxorubicin hydrochloride and hexamethylmelamine are presented. Fifteen of these patients had extensive disease at presentation. Four patients in this group died after one or fewer courses of chemotherapy. The median duration of survival for the entire group of patients is 15 months. Six patients are alive from 18 to 56 months without evidence of disease. Drug toxicity was minimal and well tolerated, which permitted this regimen to be given in an outpatient setting.

Ovarian cancer. Effective treatment after alkylating-agent failure.[Pubmed:107337]

JAMA. 1979 May 4;241(18):1908-11.

Combination chemotherapy consisting of hexamethylmelamine and cisplatin, alone or with doxorubicin hydrochloride, was given to 27 patients with advanced ovarian cancer who had disease progression with therapy including alkylating agents. Eighteen (67%) had greater than 50% regression of measurable disease or disease that could be evaluated but not measured, for a projected median duration of seven months. The projected median survival for all patients is nine months from the time of entry into the study and 33 months from the time of diagnosis of ovarian cancer. The treatment could be readily administered on an outpatient basis with a regimen of hydration and diuresis that nearly completely prevented platinum-induced renal tubular damage. Myelosuppression was severe in 11 patients (40%), but there was no treatment-related deaths. Agents of such high activity should be considered as components of initial therapy for stage III and IV cancers.

Hexamethylmelamine and hexamethylmelamine hydrochloride.[Pubmed:6808457]

Pharm Weekbl Sci. 1982 Apr 23;4(2):25-31.

Methods of analysis of the anticancer drug hexamethylmelamine, its physicochemical properties, its therapeutic uses and its fate in vivo upon oral administration, are described. The data are taken in part from the literature, in part from our own studies. The low solubility of hexamethylmelamine in water has prevented the parenteral administration of the drug to humans. The preparation of the water-soluble monohydrochloride of hexamethylmelamine, which may be suitable for this purpose, is reported, as well as its physicochemical characteristics and methods of analysis.

Comparison of DNA damage by methylmelamines and formaldehyde.[Pubmed:6788992]

J Natl Cancer Inst. 1981 Jul;67(1):217-21.

The cytoxicity and DNA damaging activity of S9-activated hexamethylmelamine (HMM) and pentamethylmelamine (PMM) were compared with suspected active metabolites in mouse leukemia L1210 cells. The presence of semicarbazide hydrochloride did not alter the cytotoxicity of S9-activated HMM and PMM or that of their hydroxylated analogs monomethylolpentamethylmelamine (MPM) and trimethyloltrimethylmelamine (TTM), which have been suggested as active metabolites. Following treatment of L1210 cells with high concentrations of activated HMM and PMM, there were no DNA single-strand breaks or interstrand cross-links observed by DNA alkaline elution and only a low frequency of DNA-protein cross-links. Formaldehyde (FA) at nonlethal concentrations caused far greater DNA-protein cross-linking. In contrast, the polyfunctional TTM produced both DNA-protein cross-linking and DNA interstrand cross-linking. The cytotoxicities of HMM and PMM were found unlikely to be related to extracellular or intracellular release of FA.

Description

Altretamine hydrochloride is an alkylating antineoplastic agent.

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