Ambocin

CAS# 108044-05-9

Ambocin

Catalog No. BCN7748----Order now to get a substantial discount!

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Quality Control of Ambocin

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Chemical structure

Ambocin

3D structure

Chemical Properties of Ambocin

Cas No. 108044-05-9 SDF Download SDF
PubChem ID 5491738 Appearance Powder
Formula C26H28O14 M.Wt 564.49
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 7-[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]oxy-5-hydroxy-3-(4-hydroxyphenyl)chromen-4-one
SMILES C1C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC=C(C4=O)C5=CC=C(C=C5)O)O)O)O)O)O)(CO)O
Standard InChIKey UXJMURXRQMFKJC-JEQMPJCPSA-N
Standard InChI InChI=1S/C26H28O14/c27-9-26(35)10-38-25(23(26)34)37-8-17-20(31)21(32)22(33)24(40-17)39-13-5-15(29)18-16(6-13)36-7-14(19(18)30)11-1-3-12(28)4-2-11/h1-7,17,20-25,27-29,31-35H,8-10H2/t17-,20-,21+,22-,23+,24-,25-,26-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ambocin

The roots of Pueraria mirifica.

Biological Activity of Ambocin

DescriptionAmbocin is a natural product from Pueraria mirifica.

Protocol of Ambocin

Structure Identification
Food Science & Biotechnology, 2014, 23(6):1815-1820.

Flavonoids from Pueraria mirifica roots and quantitative analysis using HPLC.[Reference: WebLink]


METHODS AND RESULTS:
The flavonoids, wighteone (1), naringenin (2), genistein (3), isoliquiritigenin (4), daidzein (5), daidzin (6), genistein-8-C-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside (7), Ambocin (8), and genistin (9) were isolated from roots of Pueraria mirifica. Chemical structures of the compounds were determined based on spectroscopic data analysis. Flavonoids 1, 2, 4, 7, and 8 were isolated for the first time.
CONCLUSIONS:
The contents of 6 flavonoids in P. mirifica roots was determined to be 2.5±0.01 (1), 14.8±0.09 (3), 18.6±0.18 (5), 17.3±0.11 (6), 10.4±0.05 (7), and 6.0±0.02 (9) mg/kg, respectively, using HPLC.

Ambocin Dilution Calculator

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Ambocin Molarity Calculator

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Preparing Stock Solutions of Ambocin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7715 mL 8.8576 mL 17.7151 mL 35.4302 mL 44.2878 mL
5 mM 0.3543 mL 1.7715 mL 3.543 mL 7.086 mL 8.8576 mL
10 mM 0.1772 mL 0.8858 mL 1.7715 mL 3.543 mL 4.4288 mL
50 mM 0.0354 mL 0.1772 mL 0.3543 mL 0.7086 mL 0.8858 mL
100 mM 0.0177 mL 0.0886 mL 0.1772 mL 0.3543 mL 0.4429 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ambocin

[Absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro].[Pubmed:29171242]

Zhongguo Zhong Yao Za Zhi. 2017 Aug;42(16):3206-3212.

Tongmai formula (TMF) is a drug combination of three components including Puerariae Lobatae Radix [roots of Pueraria lobata], Salviae Miltiorrhizae Radix (roots of Salvia miltiorrhiza) and Chuanxiong Rhizoma (rhizomes of Ligusticum chuanxiong) in a weight ratio of 1ratio1ratio1. The absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro were studied in this paper. The assay isoflavonoid compounds include daidzein, formononetin, 5-hydroxylononin, ononin, daidzin, 3'-methoxypuerarin, genistin, puerarin, formononetin-8-C-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside, formononetin-7-O-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside, lanceolarin, kakkanin, daidzein-7,4'-di-O-beta-D-glucopyranoside, mirificin, 3'-hydroxypuerarin, 3'-methoxydaidzin, formononetin-8-C-beta-D-xylopyranosyl-(1-->6)-O-beta-D-glucopyranoside, genistein-8-C-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside, genistein-7-O-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside (Ambocin), 3'-hydroxymirificin, 6''-O-beta-D-xylosylpuerarin, biochanin A-8-C-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside, 3'-methoxydaidzein-7,4'-di-O-beta-D-glucopyranoside, daidzein-7-O-beta-D-glucopyranosyl-(1-->4)-O-beta-D-glucopyranoside, and daidzein-7-O-alpha-D-glucopyranosyl-(1-->4)-O-beta-D-glucopyranoside. By using human Caco-2 monolayer as an intestinal epithelial cell model in vitro, the permeability of above-mentioned 25 isoflavonoids in TMF were studied from the apical (AP) side to basolateral (BL) side or from the BL side to AP side. The assay compounds were determined by reversed phased high-performance liquid chromatography (HPLC) coupled with UV detector. Transport parameters and apparent permeability coefficients (Papp) were then calculated and and compared with those of propranolol and atenolol, which are the transcellular transport marker and as a control substance for high and poor permeability, respectively. The Papp values of daidzein and formononetin were (2.55+/-0.03) x10(-)(5),(3.06+/-0.01) x10(-)(5) cm*s(-)(1) from AP side to BL side, respectively, and (2.62+/-0.00) x10(-)(5), (2.65+/-0.11) x10(-)(5) cm*s(-)(1) from BL side to AP side, respectively. Under the condition of this experiment, the Papp value was (2.66+/-0.32) x10(-)(5) cm*s(-)(1) for propranolol and (2.34+/-0.10) x10(-)(7) cm*s(-)(1) for atenolol. The Papp values of daidzein and formononetin were at a same magnitude with those of propranolol. And the Papp values of other 23 isoflavonoid compounds were at a same magnitude with those of atenolol. On the other hand, the rats of Papp AP-->BL/Papp BL-->AP of daidzein and formononetin on the influx transport were 0.97 and 1.15, respectively. It can be predicted that daidzein and formononetin can be absorbed across intestinal epithelial cells to go to the body circulation by the passive diffusion mechanism and they were assigned to the well-absorbed compounds. Other 23 isoflavonoid compounds were assigned to the poorly absorbed compounds. Because of the rats of Papp AP-->BL/Papp BL-->AP of 5-hydroxylononin, genistin, lanceolarin, kakkanin, and genistein-7-O-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside were 0.18, 0.28, 0.45, 0.38, 0.49, they may have been involved in the efflux mechanism in Caco-2 cells monolayer model from the BL side to AP side direction.

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