Aromadendrin

CAS# 480-20-6

Aromadendrin

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Chemical structure

Aromadendrin

3D structure

Chemical Properties of Aromadendrin

Cas No. 480-20-6 SDF Download SDF
PubChem ID 122850 Appearance White powder
Formula C15H12O6 M.Wt 288.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms (+)-Dihydrokaempferol
Solubility Soluble in acetone, chloroform, ethanol and methanol; slightly soluble in water
Chemical Name (2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
SMILES C1=CC(=CC=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
Standard InChIKey PADQINQHPQKXNL-LSDHHAIUSA-N
Standard InChI InChI=1S/C15H12O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,14-18,20H/t14-,15+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Aromadendrin

1 Equisetum sp. 2 Ginkgo sp. 3 Larix sp. 4 Morus sp. 5 Origanum sp. 6 Pinus sp. 7 Salix sp. 8 Silybum sp. 9 Thuja sp. 10 Thymus sp.

Biological Activity of Aromadendrin

Description1. Aromadendrin possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells. 2. Aromadendrin treatment induces adipogenesis by increases in PPARγ2 expression, resulting in stimulation of glucose uptake and ameliorated insulin resistance, suggests that it may represent a potential therapeutic candidate for the management of type 2 DM. 3. Aromadendrin has inhibitory activity on aldose reductase and the formation of advanced glycation end products.
TargetsNO | PGE | NOS | COX | NF-kB | JNK | ERK | p38MAPK | PPAR | PI3K | Akt | IkB | IKK

Aromadendrin Dilution Calculator

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Aromadendrin Molarity Calculator

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Preparing Stock Solutions of Aromadendrin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4686 mL 17.343 mL 34.6861 mL 69.3722 mL 86.7152 mL
5 mM 0.6937 mL 3.4686 mL 6.9372 mL 13.8744 mL 17.343 mL
10 mM 0.3469 mL 1.7343 mL 3.4686 mL 6.9372 mL 8.6715 mL
50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3874 mL 1.7343 mL
100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Aromadendrin

Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of NF-kappaB and Phosphorylation of JNK in RAW 264.7 Macrophage Cells.[Pubmed:24265867]

Biomol Ther (Seoul). 2013 May 30;21(3):216-21.

Aromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties. However, the underlying mechanism by which Aromadendrin exerts its biological activity has not been extensively demonstrated. The objective of this study is to elucidate the anti-inflammatory mechanism of aromadedrin in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Aromadendrin significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2. In accordance, Aromadendrin attenuated LPSinduced overexpression iNOS and COX-2. In addition, Aromadendrin significantly suppressed LPS-induced degradation of IkappaB, which sequesters NF-kappaB in cytoplasm, consequently inhibiting the nuclear translocation of pro-inflammatory transcription factor NF- kappaB. To elucidate the underlying signaling mechanism of anti-inflammatory activity of Aromadendrin, MAPK signaling pathway was examined. Aromadendrin significantly attenuated LPS-induced activation of JNK, but not ERK and p38, in a concentration-dependent manner. Taken together, the present study clearly demonstrates that Aromadendrin exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-kappaB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells.

Stimulation of glucose uptake and improvement of insulin resistance by aromadendrin.[Pubmed:22056597]

Pharmacology. 2011;88(5-6):266-74.

Agents that stimulate glucose uptake and improve insulin resistance may be useful in the management of type 2 diabetes mellitus (DM). Thus, the aims of this study were to assess the effects of Aromadendrin, a flavonoid from Gleditsia sinensis Lam., on stimulation of glucose uptake and improvement of insulin resistance and to characterize the molecular mechanisms underlying these activities. Insulin-stimulated glucose uptake was measured in HepG2 cells and in differentiated 3T3-L1 adipocytes using 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG), a fluorescent D-glucose analog. Expression of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) and adipocyte-specific fatty acid binding protein (aP2) mRNAs and the PPARgamma2 protein was analyzed in adipocytes using RT-PCR and immunoblotting, respectively. Insulin-stimulated protein kinase B (Akt/PKB) phosphorylation was measured in high glucose-induced, insulin-resistant HepG2 cells. Similar to 30 mumol/l rosiglitazone, treatment with 30 mumol/l Aromadendrin significantly stimulated insulin-sensitive glucose uptake in both HepG2 cells and 3T3-L1 adipocytes. Aromadendrin treatment also enhanced adipogenesis and caused increases in the expression of PPARgamma2 and aP2 mRNAs and the PPARgamma2 protein in differentiated 3T3-L1 adipocytes. In high glucose-induced, insulin-resistant HepG2 cells, Aromadendrin reversed the inhibition of Akt/PKB phosphorylation in response to insulin, which could be abrogated by pretreatment with LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor. Aromadendrin treatment induced adipogenesis by increases in PPARgamma2 expression, resulting in stimulation of glucose uptake and ameliorated insulin resistance. These findings suggest that Aromadendrin may represent a potential therapeutic candidate for the management of type 2 DM.

Description

Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs.

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