Home >> Research Area >>MAPK Signaling>>Raf>> B-Raf inhibitor 1 dihydrochloride

B-Raf inhibitor 1 dihydrochloride

B-Raf inhibitor,potent and selective CAS# 1191385-19-9

B-Raf inhibitor 1 dihydrochloride

Catalog No. BCC4183----Order now to get a substantial discount!

Product Name & Size Price Stock
B-Raf inhibitor 1 dihydrochloride: 5mg Please Inquire In Stock
B-Raf inhibitor 1 dihydrochloride: 10mg Please Inquire In Stock
B-Raf inhibitor 1 dihydrochloride: 20mg Please Inquire Please Inquire
B-Raf inhibitor 1 dihydrochloride: 50mg Please Inquire Please Inquire
B-Raf inhibitor 1 dihydrochloride: 100mg Please Inquire Please Inquire
B-Raf inhibitor 1 dihydrochloride: 200mg Please Inquire Please Inquire
B-Raf inhibitor 1 dihydrochloride: 500mg Please Inquire Please Inquire
B-Raf inhibitor 1 dihydrochloride: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of B-Raf inhibitor 1 dihydrochloride

Number of papers citing our products

Chemical structure

B-Raf inhibitor 1 dihydrochloride

3D structure

Chemical Properties of B-Raf inhibitor 1 dihydrochloride

Cas No. 1191385-19-9 SDF Download SDF
PubChem ID 44247765 Appearance Powder
Formula C26H21Cl3N8 M.Wt 551.86
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO
Chemical Name 1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine;dihydrochloride
SMILES CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6.Cl.Cl
Standard InChIKey HRLQRNBAJCQMMG-UHFFFAOYSA-N
Standard InChI InChI=1S/C26H19ClN8.2ClH/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23;;/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33);2*1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of B-Raf inhibitor 1 dihydrochloride

DescriptionB-Raf inhibitor 1 dihydrochloride is a potent and selective inhibitor of B-Raf with IC50 values of 0.31 μM and 2 nM for A375 proliferation and A375 p-ERK, respectively.
TargetsA375 proliferationA375 p-ERK    
IC500.31 μM2 nM    

B-Raf inhibitor 1 dihydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

B-Raf inhibitor 1 dihydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of B-Raf inhibitor 1 dihydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8121 mL 9.0603 mL 18.1205 mL 36.2411 mL 45.3013 mL
5 mM 0.3624 mL 1.8121 mL 3.6241 mL 7.2482 mL 9.0603 mL
10 mM 0.1812 mL 0.906 mL 1.8121 mL 3.6241 mL 4.5301 mL
50 mM 0.0362 mL 0.1812 mL 0.3624 mL 0.7248 mL 0.906 mL
100 mM 0.0181 mL 0.0906 mL 0.1812 mL 0.3624 mL 0.453 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on B-Raf inhibitor 1 dihydrochloride

B-Raf inhibitor 1 is an inhibitor of B-Raf kinase with IC50 values of 0.31μM and 0.72μM for cell proliferation, respectively in A375 and HCT116 [1].

B-Raf is important in signal transduction and some mutant B-Raf occurs in cancer cells. The most common mutation of these is V600E, which makes B-Raf kinase constitutively active. B-Raf inhibitor 1 belongs to the type IIA inhibitors and binds to the DFG-out ATP-binding site of B-Raf. The selectivity of B-Raf inhibitor 1 is less than of other type inhibitors. Besides mutant B-Raf, it can also inhibit wild type B-Raf and other tyrosine kinase. In cells with wild type B-Raf, B-Raf inhibitor 1 can activate the RAF-MEK-ERK signaling pathway via Raf dimerization. The preclinical toxicity test shows B-Raf inhibitor 1 can induce hyperplasia in a mouse model [1, 2].

References:
[1] Wang X, Kim J. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41.
[2] Smith AL, DeMorin FF, Paras NA, Huang Q, Petkus JK, Doherty EM, Nixey T, Kim JL, Whittington DA, Epstein LF, Lee MR, Rose MJ, Babij C, Fernando M, Hess K, Le Q, Beltran P, Carnahan J. Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. J Med Chem. 2009 Oct 22;52(20):6189-92.

Featured Products
New Products
 

Description

B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.

Keywords:

B-Raf inhibitor 1 dihydrochloride,1191385-19-9,Natural Products,Raf, buy B-Raf inhibitor 1 dihydrochloride , B-Raf inhibitor 1 dihydrochloride supplier , purchase B-Raf inhibitor 1 dihydrochloride , B-Raf inhibitor 1 dihydrochloride cost , B-Raf inhibitor 1 dihydrochloride manufacturer , order B-Raf inhibitor 1 dihydrochloride , high purity B-Raf inhibitor 1 dihydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: