Bakkenolide B

CAS# 18455-98-6

Bakkenolide B

Catalog No. BCN7207----Order now to get a substantial discount!

Product Name & Size Price Stock
Bakkenolide B: 5mg $828 In Stock
Bakkenolide B: 10mg Please Inquire In Stock
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Quality Control of Bakkenolide B

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Chemical structure

Bakkenolide B

3D structure

Chemical Properties of Bakkenolide B

Cas No. 18455-98-6 SDF Download SDF
PubChem ID 11165211 Appearance Powder
Formula C22H30O6 M.Wt 390.47
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(2R,3R,3aR,4S,7S,7aR)-3-acetyloxy-7,7a-dimethyl-4'-methylidene-2'-oxospiro[3,3a,4,5,6,7-hexahydro-1H-indene-2,3'-oxolane]-4-yl] (Z)-2-methylbut-2-enoate
SMILES CC=C(C)C(=O)OC1CCC(C2(C1C(C3(C2)C(=C)COC3=O)OC(=O)C)C)C
Standard InChIKey AVAGQVZSHJYDED-RRIKAWJQSA-N
Standard InChI InChI=1S/C22H30O6/c1-7-12(2)19(24)28-16-9-8-13(3)21(6)11-22(14(4)10-26-20(22)25)18(17(16)21)27-15(5)23/h7,13,16-18H,4,8-11H2,1-3,5-6H3/b12-7-/t13-,16-,17+,18+,21+,22+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Bakkenolide B

The leaves of Peatasites japonicus.

Biological Activity of Bakkenolide B

Description1. Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
TargetsNOS | COX

Bakkenolide B Dilution Calculator

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Bakkenolide B Molarity Calculator

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Preparing Stock Solutions of Bakkenolide B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.561 mL 12.8051 mL 25.6102 mL 51.2203 mL 64.0254 mL
5 mM 0.5122 mL 2.561 mL 5.122 mL 10.2441 mL 12.8051 mL
10 mM 0.2561 mL 1.2805 mL 2.561 mL 5.122 mL 6.4025 mL
50 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.0244 mL 1.2805 mL
100 mM 0.0256 mL 0.1281 mL 0.2561 mL 0.5122 mL 0.6403 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Bakkenolide B

Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves.[Pubmed:23711828]

J Ethnopharmacol. 2013 Jul 30;148(3):890-4.

AIMS OF THE STUDY: To elucidate the anti-allergic and anti-inflammatory effects of Petasites genus, we studied the effects of several compounds isolated from Petasites japonicas leaves. MATERIALS AND METHODS: Bakkenolide B was isolated from Petasites japonicus leaves. Antigen-induced degranulation was measured in RBL-2H3 mast cells by measuring beta-hexosamidase activity. Induction of inducible nitric oxide synthase and cyclooxygenase 2 was measured by Western blotting in peritoneal macrophages. Ovalbumin-induced asthma model was used for in vivo efficacy test of bakkanolide B. RESULTS: We found that Bakkenolide B, a major component of the leaves, concentration-dependently inhibited RBL-2H3 mast cell degranulation. Bakkenolide B also inhibited the gene inductions of inducible nitric oxide synthase and cyclooxygenase 2 in mouse peritoneal macrophages. Furthermore, in an ovalbumin-induced asthma model, Bakkenolide B strongly inhibited the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid. CONCLUSION: Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.

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