CU CPT 4a

Selective TLR3 inhibitor CAS# 1279713-77-7

CU CPT 4a

Catalog No. BCC6319----Order now to get a substantial discount!

Product Name & Size Price Stock
CU CPT 4a: 5mg $115 In Stock
CU CPT 4a: 10mg Please Inquire In Stock
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Quality Control of CU CPT 4a

Number of papers citing our products

Chemical structure

CU CPT 4a

3D structure

Chemical Properties of CU CPT 4a

Cas No. 1279713-77-7 SDF Download SDF
PubChem ID 53242268 Appearance Powder
Formula C18H13ClFNO3S M.Wt 377.82
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
Chemical Name (2R)-2-[(3-chloro-6-fluoro-1-benzothiophene-2-carbonyl)amino]-3-phenylpropanoic acid
SMILES C1=CC=C(C=C1)CC(C(=O)O)NC(=O)C2=C(C3=C(S2)C=C(C=C3)F)Cl
Standard InChIKey IAASQMCXDRISAV-CYBMUJFWSA-N
Standard InChI InChI=1S/C18H13ClFNO3S/c19-15-12-7-6-11(20)9-14(12)25-16(15)17(22)21-13(18(23)24)8-10-4-2-1-3-5-10/h1-7,9,13H,8H2,(H,21,22)(H,23,24)/t13-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of CU CPT 4a

DescriptionSelective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells.

CU CPT 4a Dilution Calculator

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CU CPT 4a Molarity Calculator

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Preparing Stock Solutions of CU CPT 4a

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6468 mL 13.2338 mL 26.4676 mL 52.9353 mL 66.1691 mL
5 mM 0.5294 mL 2.6468 mL 5.2935 mL 10.5871 mL 13.2338 mL
10 mM 0.2647 mL 1.3234 mL 2.6468 mL 5.2935 mL 6.6169 mL
50 mM 0.0529 mL 0.2647 mL 0.5294 mL 1.0587 mL 1.3234 mL
100 mM 0.0265 mL 0.1323 mL 0.2647 mL 0.5294 mL 0.6617 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on CU CPT 4a

Small-molecule inhibitors of the TLR3/dsRNA complex.[Pubmed:21355588]

J Am Chem Soc. 2011 Mar 23;133(11):3764-7.

The protein-RNA interface has been regarded as "undruggable" despite its importance in many biological processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers. We describe the development of a series of small-molecule probes that were shown to be competitive inhibitors of dsRNA binding to TLR3 with high affinity and specificity. In a multitude of assays, compound 4a was profiled as a potent antagonist to TLR3 signaling and also repressed the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-alpha and IL-1beta.

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