Home >> Research Area >>Natural Products>>Triterpenoids>> Chikusetsusaponin IV

Chikusetsusaponin IV

CAS# 7518-22-1

Chikusetsusaponin IV

Catalog No. BCN2683----Order now to get a substantial discount!

Product Name & Size Price Stock
Chikusetsusaponin IV: 5mg $86 In Stock
Chikusetsusaponin IV: 10mg Please Inquire In Stock
Chikusetsusaponin IV: 20mg Please Inquire Please Inquire
Chikusetsusaponin IV: 50mg Please Inquire Please Inquire
Chikusetsusaponin IV: 100mg Please Inquire Please Inquire
Chikusetsusaponin IV: 200mg Please Inquire Please Inquire
Chikusetsusaponin IV: 500mg Please Inquire Please Inquire
Chikusetsusaponin IV: 1000mg Please Inquire Please Inquire

Quality Control of Chikusetsusaponin IV

Number of papers citing our products

Chemical structure

Chikusetsusaponin IV

3D structure

Chemical Properties of Chikusetsusaponin IV

Cas No. 7518-22-1 SDF Download SDF
PubChem ID 197091 Appearance White powder
Formula C47H74O18 M.Wt 927.08
Type of Compound Triterpenoids Storage Desiccate at -20°C
Synonyms Chikusetsusaponin IV; Oleanoside E
Solubility Soluble in acetonitrile and methanol; insoluble in water
Chemical Name (2S,3S,4R,5R,6S)-6-[[(6aR,6bS,8aS,12aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid
SMILES CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(O7)CO)O)O)O)O)C)C)C2C1)C)C(=O)OC8C(C(C(C(O8)CO)O)O)O)C
Standard InChIKey KQSFNXMDCOFFGW-UGBTYEQWSA-N
Standard InChI InChI=1S/C47H74O18/c1-42(2)14-16-47(41(59)65-39-33(55)30(52)28(50)23(19-48)61-39)17-15-45(6)21(22(47)18-42)8-9-26-44(5)12-11-27(43(3,4)25(44)10-13-46(26,45)7)62-40-34(56)31(53)35(36(64-40)37(57)58)63-38-32(54)29(51)24(20-49)60-38/h8,22-36,38-40,48-56H,9-20H2,1-7H3,(H,57,58)/t22-,23-,24+,25?,26?,27?,28-,29+,30+,31-,32-,33-,34-,35+,36+,38+,39+,40+,44+,45-,46-,47+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Chikusetsusaponin IV

1 Panax sp.

Biological Activity of Chikusetsusaponin IV

Description1. Chikusetsusaponin IV might relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway.

Chikusetsusaponin IV Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Chikusetsusaponin IV Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Chikusetsusaponin IV

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.0787 mL 5.3933 mL 10.7866 mL 21.5731 mL 26.9664 mL
5 mM 0.2157 mL 1.0787 mL 2.1573 mL 4.3146 mL 5.3933 mL
10 mM 0.1079 mL 0.5393 mL 1.0787 mL 2.1573 mL 2.6966 mL
50 mM 0.0216 mL 0.1079 mL 0.2157 mL 0.4315 mL 0.5393 mL
100 mM 0.0108 mL 0.0539 mL 0.1079 mL 0.2157 mL 0.2697 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Chikusetsusaponin IV

Suppression of Fas-mediated apoptosis of keratinocyte cells by chikusetsusaponins isolated from the roots of Panax japonicus.[Pubmed:16534721]

Planta Med. 2006 Feb;72(3):193-8.

Fas-mediated apoptotic cell death of a human keratinocyte cell line, HaCaT cells, and of a murine keratinocyte cell line, Pam212 cells, was suppressed by pre-treatment with a methanol extract from the roots of Panax japonicus C.A. Meyer. Activity-guided fractionation led to the isolation of chikusetsusaponins IV, IVa, V and polysciasaponin P5 as the active ingredients. Of these compounds, Chikusetsusaponin IV, was most active when applied at a concentration of 12.5 microg/mL. The intracellular hallmark events of apoptosis such as DNA fragmentation and chromatin condensation were significantly reduced by the treatment with Chikusetsusaponin IV. The apoptotic cell death of Jurkat cells was also suppressed by treatment with the active saponins. These results suggest that the use of chikusetsusaponins IV, IVa, V, polysciasaponin P5, or a crude extract of P. japonicus containing these saponins is expected to relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway.

Description

Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM.

Keywords:

Chikusetsusaponin IV,7518-22-1,Chikusetsusaponin IV; Oleanoside E,Natural Products, buy Chikusetsusaponin IV , Chikusetsusaponin IV supplier , purchase Chikusetsusaponin IV , Chikusetsusaponin IV cost , Chikusetsusaponin IV manufacturer , order Chikusetsusaponin IV , high purity Chikusetsusaponin IV

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: