Cimilactone A

CAS# 468733-06-4

Cimilactone A

Catalog No. BCN7948----Order now to get a substantial discount!

Product Name & Size Price Stock
Cimilactone A: 5mg Please Inquire In Stock
Cimilactone A: 10mg Please Inquire In Stock
Cimilactone A: 20mg Please Inquire Please Inquire
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Cimilactone A: 100mg Please Inquire Please Inquire
Cimilactone A: 200mg Please Inquire Please Inquire
Cimilactone A: 500mg Please Inquire Please Inquire
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Quality Control of Cimilactone A

Number of papers citing our products

Chemical structure

Cimilactone A

3D structure

Chemical Properties of Cimilactone A

Cas No. 468733-06-4 SDF Download SDF
PubChem ID 10908062 Appearance Powder
Formula C33H50O9 M.Wt 590.74
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1CC(=O)OC2C1C3(C(CC45CC46CCC(C(C6CCC5C3(C2)C)(C)C)OC7C(C(C(CO7)O)O)O)OC(=O)C)C
Standard InChIKey RKTWPXXLEHCPIO-DWWJFHMPSA-N
Standard InChI InChI=1S/C33H50O9/c1-16-11-24(36)41-19-12-30(5)21-8-7-20-29(3,4)22(42-28-27(38)26(37)18(35)14-39-28)9-10-32(20)15-33(21,32)13-23(40-17(2)34)31(30,6)25(16)19/h16,18-23,25-28,35,37-38H,7-15H2,1-6H3/t16-,18-,19+,20+,21+,22+,23-,25+,26+,27-,28+,30+,31-,32-,33+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cimilactone A

The herbs of Curculigo orchioides

Biological Activity of Cimilactone A

Description1. Cimilactone A shows significant anticomplement activity (IC(50)= 28.6 microm).

Cimilactone A Dilution Calculator

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Cimilactone A Molarity Calculator

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Preparing Stock Solutions of Cimilactone A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6928 mL 8.464 mL 16.9279 mL 33.8558 mL 42.3198 mL
5 mM 0.3386 mL 1.6928 mL 3.3856 mL 6.7712 mL 8.464 mL
10 mM 0.1693 mL 0.8464 mL 1.6928 mL 3.3856 mL 4.232 mL
50 mM 0.0339 mL 0.1693 mL 0.3386 mL 0.6771 mL 0.8464 mL
100 mM 0.0169 mL 0.0846 mL 0.1693 mL 0.3386 mL 0.4232 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cimilactone A

Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells.[Pubmed:17266751]

Beilstein J Org Chem. 2007 Jan 31;3:3.

Two new cycloartane-type triterpene glycosides, namely cimicifoetisides A (1) and B (2), along with seven known compounds cimigenol, 25-O-acetylcimigenol, cimigenol 3-O-beta-D-xylopyranoside, 12beta-hydroxycimigenol 3-O-beta-D-xylopyranoside, cimigenol 3-O-alpha-L-arabinopyranoside, 25-deoxyshengmanol 3-O-beta-D-xylopyranoside and Cimilactone A, were isolated from the rhizomes of Cimicifuga foetida. Their structures were elucidated as cimigenol 3-O-(2'-O-acetyl)-alpha-L-arabinopyranoside (1) and 25-O-acetylcimigenol 3-O-(2'-O-acetyl)-alpha-L-arabinopyranoside (2). Both compounds 1 and 2 exhibited potent cytotoxicity against rat EAC (Ehrlich ascites carcinoma) and MDA-MB-A231 (human breast cancer) cells with IC50 values of 0.52 and 6.74 microM for 1, and 0.19 and 10.21 microM for 2, suggesting their potential for further investigation as anti-cancer agents.

Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida.[Pubmed:16906637]

Phytother Res. 2006 Nov;20(11):945-8.

A tetranor-cycloartane glycoside and two 9,19-cycloartane glycosides were isolated from the EtOAc-soluble fraction of the rhizome of Cimicifuga foetida. The structures of the compounds were determined to be Cimilactone A (1), 25-O-acetylcimigenol 3-O-beta-d-xylopyranoside (2) and cimigenol 3-O-alpha-l-arabinopyranoside (3), respectively, using spectroscopic analysis. The three compounds were examined for their anticomplement activity against the classical pathway of the complement system. Compound 1 showed significant anticomplement activity with an IC(50) value of 28.6 microm, whereas compounds 2 and 3 were inactive.

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