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Cycloart-24-ene-1alpha,2alpha,3beta-triol

CAS# 942407-97-8

Cycloart-24-ene-1alpha,2alpha,3beta-triol

Catalog No. BCN7983----Order now to get a substantial discount!

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Cycloart-24-ene-1alpha,2alpha,3beta-triol: 5mg Please Inquire In Stock
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Cycloart-24-ene-1alpha,2alpha,3beta-triol: 1000mg Please Inquire Please Inquire

Quality Control of Cycloart-24-ene-1alpha,2alpha,3beta-triol

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Chemical structure

Cycloart-24-ene-1alpha,2alpha,3beta-triol

3D structure

Chemical Properties of Cycloart-24-ene-1alpha,2alpha,3beta-triol

Cas No. 942407-97-8 SDF Download SDF
PubChem ID 16681226 Appearance Powder
Formula C30H50O3 M.Wt 458.72
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(CCC=C(C)C)C1CCC2(C1(CCC34C2CCC5C3(C4)C(C(C(C5(C)C)O)O)O)C)C
Standard InChIKey DATCMCBQCCLKRF-QMIHFCROSA-N
Standard InChI InChI=1S/C30H50O3/c1-18(2)9-8-10-19(3)20-13-14-28(7)22-12-11-21-26(4,5)24(32)23(31)25(33)30(21)17-29(22,30)16-15-27(20,28)6/h9,19-25,31-33H,8,10-17H2,1-7H3/t19-,20-,21+,22+,23+,24+,25+,27-,28+,29+,30-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cycloart-24-ene-1alpha,2alpha,3beta-triol

The herbs of Pongamia pinnata

Biological Activity of Cycloart-24-ene-1alpha,2alpha,3beta-triol

DescriptionCycloartan-24-ene-1α,2α,3β-triol, as a potential anticancer drug, it exerts significantly pro-apoptotic activity against human hormone-independent prostatic cancer.
TargetsBcl-2/Bax | Caspase
In vitro

Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells.[Reference: WebLink]

Oncology Reports, 2015, 33(3):1107-1114.

Plant-derived antitumor drugs are currently used in chemotherapy. Cycloartane triterpenoids have shown a cytotoxic effect on human prostate cancer cells. The aim of the present study was to isolate a cycloartane triterpenoid from Commiphora myrrha and evaluate its anticancer potential.
METHODS AND RESULTS:
Cycloartan-24-ene-1α,2α,3β-triol (Cycloart-24-ene-1alpha,2alpha,3beta-triol ,MY-1) was isolated from Commiphora myrrha, and its structure was determined through 1H and 13C nuclear magnetic resonance spectroscopy. The cytotoxic and apoptotic effects of MY-1 on human prostatic cancer PC-3 cells were estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometric analysis and terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) staining assay, and the expression of apoptotic-related proteins were evaluated by western blotting. MY-1 showed cytotoxic activity on PC-3 cells in a concentration-dependent manner with an IC50 value of 9.6 µM at 24 h. MY-1 induced cell cycle arrest and apoptosis. Western blot analysis revealed that MY-1 regulated the expression levels of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), p53 and caspase-3 in the PC-3 cells.
CONCLUSIONS:
These findings indicate that MY-1 exerts significantly pro-apoptotic activity against human hormone-independent prostatic cancer and support MY-1 as a potential anticancer drug.

Antiproliferative effect of cycloartane-type triterpenoid from myrrh against human prostate cancer cells.[Pubmed: 24761675]

Journal of Chinese medicinal materials, 2013, 36(10):1640-1643.

To investigate the antiproliferative effect of cycloartan-24-ene-1alpha, 2alpha, 3beta-triol(Cycloart-24-ene-1alpha,2alpha,3beta-triol ) from Myrrh against human prostate cancer cells.
METHODS AND RESULTS:
Morphological changes of compound-treated human prostate PC3 cells were determined by staining cells with Hoechst. The cell cycle progression and apoptosis were evaluated using flow cytometry assay. Apoptosis related protein levels were analyzed using Western blotting. Treatment of PC3 cells with cycloartan-24-ene-1alpha,2alpha,3beta-triol caused an increase ratio of apoptotic cells, which was verified by flow cytometry. It was also found that cycloartan-24-ene-1alpha,2alpha, 3beta-triol arrested cell cycle at the G0/G1 phase. Apoptosis related proteins, such as BCL-2, BAX, Caspase-3 and Caspase-9 were changed.
CONCLUSIONS:
These observes data indicate that cycloartan-24-ene-1alpha,2alpha,3beta-triol inhibit the proliferation of PC3 cells via induction of apoptosis and cell cycle arrest.

Cycloart-24-ene-1alpha,2alpha,3beta-triol Dilution Calculator

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Cycloart-24-ene-1alpha,2alpha,3beta-triol Molarity Calculator

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Preparing Stock Solutions of Cycloart-24-ene-1alpha,2alpha,3beta-triol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.18 mL 10.8999 mL 21.7998 mL 43.5996 mL 54.4995 mL
5 mM 0.436 mL 2.18 mL 4.36 mL 8.7199 mL 10.8999 mL
10 mM 0.218 mL 1.09 mL 2.18 mL 4.36 mL 5.4499 mL
50 mM 0.0436 mL 0.218 mL 0.436 mL 0.872 mL 1.09 mL
100 mM 0.0218 mL 0.109 mL 0.218 mL 0.436 mL 0.545 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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