DihydrobaicalinCAS# 56226-98-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 56226-98-3 | SDF | Download SDF |
| PubChem ID | 14135325.0 | Appearance | Powder |
| Formula | C21H20O11 | M.Wt | 448.38 |
| Type of Compound | Dihydroflavones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S,3S,4S,5R,6S)-6-[[(2S)-5,6-dihydroxy-4-oxo-2-phenyl-2,3-dihydrochromen-7-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid | ||
| SMILES | C1C(OC2=CC(=C(C(=C2C1=O)O)O)OC3C(C(C(C(O3)C(=O)O)O)O)O)C4=CC=CC=C4 | ||
| Standard InChIKey | UVNUGBQJLDGZKE-XDZPIWCFSA-N | ||
| Standard InChI | InChI=1S/C21H20O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-5,7,10,16-19,21,23-27H,6H2,(H,28,29)/t10-,16-,17-,18+,19-,21+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Dihydrobaicalin Dilution Calculator
Dihydrobaicalin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2303 mL | 11.1513 mL | 22.3025 mL | 44.605 mL | 55.7563 mL |
| 5 mM | 0.4461 mL | 2.2303 mL | 4.4605 mL | 8.921 mL | 11.1513 mL |
| 10 mM | 0.223 mL | 1.1151 mL | 2.2303 mL | 4.4605 mL | 5.5756 mL |
| 50 mM | 0.0446 mL | 0.223 mL | 0.4461 mL | 0.8921 mL | 1.1151 mL |
| 100 mM | 0.0223 mL | 0.1115 mL | 0.223 mL | 0.4461 mL | 0.5576 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Segetalin C
Catalog No.:BCX1230
CAS No.:177602-12-9
- 2,7-dihydroxy-4, 6-dimethoxy phenanthrene
Catalog No.:BCX1229
CAS No.:108352-70-1
- Argentinogenin
Catalog No.:BCX1228
CAS No.:4236-48-0
- β-Obscurin
Catalog No.:BCX1227
CAS No.:467-79-8
- Cnidimol B
Catalog No.:BCX1226
CAS No.:103629-81-8
- Erythro-guaiacylglycerol-β-O-4'-sinapyl ether
Catalog No.:BCX1225
CAS No.:905726-70-7
- threo-guaiacylglycerol-β-O-4'-sinapyl ether
Catalog No.:BCX1224
CAS No.:288864-26-6
- 5,7-Dihydroxychroman-4-one
Catalog No.:BCX1223
CAS No.:108085-46-7
- 7,3',5'-Trihydroxyflavanone
Catalog No.:BCX1222
CAS No.:847375-46-6
- 7'R,8'R-2,2'-Dimethoxy-4-(3-hydroxyl-propenyl)-4'-(1,2,3-trihydroxy-propyl) biphenyl ether
Catalog No.:BCX1221
CAS No.:515813-60-2
- 7,8,3',4'-Tetrahydroxyflavanone
Catalog No.:BCX1220
CAS No.:489-73-6
- Sinocrassoside C1
Catalog No.:BCX1219
CAS No.:909803-26-5
- Isocoreopsin
Catalog No.:BCX1232
CAS No.:30382-18-4
- Sikokianin E
Catalog No.:BCX1233
CAS No.:2253791-96-5
- 2-(3,4-dihydroxyphenyl)-7-(β-D-glucopyranosyloxy)-8-hydroxy-4H-1-benzopyran-4-one
Catalog No.:BCX1234
CAS No.:925701-05-9
- Hedysarimcoumestan B
Catalog No.:BCX1235
CAS No.:899436-04-5
- t-OMe-Byakangelicin
Catalog No.:BCX1236
CAS No.:89560-97-4
- Albanol B
Catalog No.:BCX1237
CAS No.:87084-99-9
- Ekersenin
Catalog No.:BCX1238
CAS No.:53091-74-0
- Oxypeucedanin methanolate
Catalog No.:BCX1239
CAS No.:52939-12-5
- 1-O-gentiobiosyl-3,7-dimethoxy-8-hydroxyxanthone
Catalog No.:BCX1240
CAS No.:487040-33-5
- Chikusaikoside II
Catalog No.:BCX1241
CAS No.:166338-14-3
- Damnacanthol
Catalog No.:BCX1242
CAS No.:477-83-8
- Aconicarchamine B
Catalog No.:BCX1243
CAS No.:1275535-67-5
A multistep approach for exploring quality markers of Shengjiang Xiexin decoction by integrating plasma pharmacochemistry-pharmacokinetics-pharmacology.[Pubmed:38306867]
J Pharm Biomed Anal. 2024 Apr 15;241:115999.
Shengjiang Xiexin decoction (SXD), a well-known traditional Chinese medicine (TCM), was used to alleviate delayed-onset diarrhea induced by the chemotherapeutic agent irinotecan (CPT-11). Our previous study showed that SXD regulated multidrug resistance-associated protein 2 (Mrp-2) to alter the pharmacokinetics of CPT-11 and its metabolites. However, the pharmacodynamic constituents and the related quality markers of SXD are unclear. In this study, ultra-high performance liquid chromatography coupled with quadrupole orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was utilized to identify the prototypes and metabolites in rat plasma after oral administration of SXD. The pharmacokinetic markers (PK markers) were screened through quantification and semiquantification of SXD-related xenobiotics in plasma using liquid chromatography-mass spectrometry (LC-MS) combined with statistical analysis. Computational molecular docking was performed to assess the potential binding ability of the PK markers with the target Mrp-2. The results were verified by evaluating the impact on Mrp-2 function using Caco-2 cells. The quality markers were chosen from these PK markers based on the binding affinities with Mrp-2, the specificity and the traceability. As a result, a total of 142 SXD-related exogenous components, including 77 prototypes and 65 metabolites, were detected in rat plasma. Among these, 83 xenobiotics were selected as PK markers due to their satisfactory pharmacokinetic behaviors. Based on the characteristics of quality markers, the prototype-based PK markers were considered the indices of quality control for SXD, including baicalin, baicalein, wogonoside, wogonin, liquiritigenin, isoliquiritigenin, norwogonin, oroxylin A, Dihydrobaicalin, chrysin, glycyrrhizic acid, glycyrrhetinic acid, oroxylin A 7-O-glucuronide, liquiritin and isoliquiritin. This study provided an interesting strategy for screening the quality markers involved in the pharmacokinetics of SXD and its action target, which offered important information for the modernization of SXD and other TCM formulae.
Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus.[Pubmed:22000800]
Comput Biol Chem. 2011 Oct 12;35(5):293-7.
Many Traditional Chinese Medicines (TCMs) are effective to relieve complicated diseases such as type II diabetes mellitus (T2DM). In this work, molecular docking and network analysis were employed to elucidate the action mechanism of a medical composition which had clinical efficacy for T2DM. We found that multiple active compounds contained in this medical composition would target multiple proteins related to T2DM and the biological network would be shifted. We predicted the key players in the medical composition and some of them have been reported in literature. Meanwhile, several compounds such as Rheidin A, Rheidin C, Sennoside C, procyanidin C1 and Dihydrobaicalin were notable although no one have reported their pharmacological activity against T2DM. The association between active compounds, target proteins and other diseases was also discussed.
Analysis of Scutellaria lateriflora and its adulterants Teucrium canadense and Teucrium chamaedrys by LC-UV/MS, TLC, and digital photomicroscopy.[Pubmed:12852558]
J AOAC Int. 2003 May-Jun;86(3):453-60.
Methods using liquid chromatography with UV detection (LC-UV), thin-layer chromatography (TLC), and digital photomicroscopy were developed to distinguish between the different species of Scutellaria lateriflora L. and its adulterants Teucrium canadense L. and T. chamaedrys L. Chemically, the 70% ethanol extract of S. lateriflora is characterized by the presence of flavonoids--predominantly baicalin, lateriflorin, Dihydrobaicalin, and baicalein. The major compounds of the 70% ethanol extract of T. canadense are phenylpropanoids, with verbascoside as the most prominent, and a variable amount of teucrioside. Teucrioside is the major compound in T. chamaedrys, but it is not present in S. lateriflora. The presence of phenylpropane glycosides can therefore be used to distinguish between the S. lateriflora L. and the two Teucrium species by LC-UV and TLC. The abundant strap-shaped trichomes on the stem, as well as bristle-like trichomes on the leaf, are typically seen microscopically for T. canadense, whereas the waxy cuticle with numerous glandular scales is found in T. chamaedrys. These cell structures were used to determine the adulteration of S. lateriflora crude herb with either of the two Teucrium species.
