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Dihydrodehydrodiconiferyl alcohol

CAS# 28199-69-1

Dihydrodehydrodiconiferyl alcohol

Catalog No. BCN5176----Order now to get a substantial discount!

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Dihydrodehydrodiconiferyl alcohol: 5mg Please Inquire In Stock
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Chemical structure

Dihydrodehydrodiconiferyl alcohol

3D structure

Chemical Properties of Dihydrodehydrodiconiferyl alcohol

Cas No. 28199-69-1 SDF Download SDF
PubChem ID 384679 Appearance Powder
Formula C20H24O6 M.Wt 360.4
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-[(2S,3R)-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-2,3-dihydro-1-benzofuran-2-yl]-2-methoxyphenol
SMILES COC1=C(C=CC(=C1)C2C(C3=CC(=CC(=C3O2)OC)CCCO)CO)O
Standard InChIKey SBLZVJIHPWRSQQ-HNAYVOBHSA-N
Standard InChI InChI=1S/C20H24O6/c1-24-17-10-13(5-6-16(17)23)19-15(11-22)14-8-12(4-3-7-21)9-18(25-2)20(14)26-19/h5-6,8-10,15,19,21-23H,3-4,7,11H2,1-2H3/t15-,19+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dihydrodehydrodiconiferyl alcohol

The barks of Eucommia ulmoides Oliver

Biological Activity of Dihydrodehydrodiconiferyl alcohol

Description1. Dihydrodehydrodiconiferyl alcohol may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis. 2. Dihydrodehydrodiconiferyl alcohol exhibits in vitro cytotoxicity in various cancer cell lines.
TargetsTNF-α

Dihydrodehydrodiconiferyl alcohol Dilution Calculator

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Dihydrodehydrodiconiferyl alcohol Molarity Calculator

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Preparing Stock Solutions of Dihydrodehydrodiconiferyl alcohol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7747 mL 13.8735 mL 27.7469 mL 55.4939 mL 69.3674 mL
5 mM 0.5549 mL 2.7747 mL 5.5494 mL 11.0988 mL 13.8735 mL
10 mM 0.2775 mL 1.3873 mL 2.7747 mL 5.5494 mL 6.9367 mL
50 mM 0.0555 mL 0.2775 mL 0.5549 mL 1.1099 mL 1.3873 mL
100 mM 0.0277 mL 0.1387 mL 0.2775 mL 0.5549 mL 0.6937 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dihydrodehydrodiconiferyl alcohol

Antifibrotic compounds from Liriodendron tulipifera attenuating HSC-T6 proliferation and TNF-alpha production in RAW264.7 cells.[Pubmed:25747981]

Biol Pharm Bull. 2015;38(2):228-34.

The inhibition of hepatic stellate cell (HSC) proliferation has been considered as an effective therapeutic target for the treatment of liver fibrosis. The methanolic extract of Liriodendron tulipifera showed significant inhibitory activity against the proliferation of HSCs. Bioactivity-guided isolation afforded twelve compounds including (-)-sesamin (1), (-)-syringaresinol (2), (+)-Dihydrodehydrodiconiferyl alcohol (3), salvinal (4), (+)-guaiacylglycerol-8-O-4'-dihydroconiferyl ether (5), (+/-)-guaiacylglycerol-8-O-4'-sinapyl alcohol ether (6), tanegool (7), (+)-5,5'-dimethoxy-7-oxolariciresinol (8), 3-hydroxy-4-methoxyacetophenone (9), 4-acetoxymethylphenol (10), (-)-paramicholide (11), and blumenol A (12). Among the compounds isolated, 2, 3 and 4 significantly attenuated the proliferation of the activated HSC-T6 cells. The maximal dose of these compounds, however, showed no cytotoxicity in primary cultured rat hepatocytes. Collagen deposition in the activated HSC-T6 cells was reduced by 2, 3 and 4. Also, the increased production of the pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha induced by lipopolysaccharide was decreased by 3 and 4 in RAW264.7 macrophage cells. Collectively, (-)-syringaresinol (2), (+)-Dihydrodehydrodiconiferyl alcohol (3), and salvinal (4) isolated from L. tulipifera leaves and twigs exhibited selective antifibrotic activities toward the activated HSCs and suppressed TNF-alpha production in RAW264.7 macrophages. These compounds may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis.

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