Home >> Research Area >>Neuroscience>>Nicotinic Receptor>> EVP-6124 hydrochloride

EVP-6124 hydrochloride

Alpha7 nAChR agonist CAS# 550999-74-1

EVP-6124 hydrochloride

Catalog No. BCC1567----Order now to get a substantial discount!

Product Name & Size Price Stock
EVP-6124 hydrochloride: 5mg $322 In Stock
EVP-6124 hydrochloride: 10mg Please Inquire In Stock
EVP-6124 hydrochloride: 20mg Please Inquire Please Inquire
EVP-6124 hydrochloride: 50mg Please Inquire Please Inquire
EVP-6124 hydrochloride: 100mg Please Inquire Please Inquire
EVP-6124 hydrochloride: 200mg Please Inquire Please Inquire
EVP-6124 hydrochloride: 500mg Please Inquire Please Inquire
EVP-6124 hydrochloride: 1000mg Please Inquire Please Inquire
Related Products
  • RJR-2403

    Catalog No.:BCC1901
    CAS No.:15585-43-0
  • RJR-2403 oxalate

    Catalog No.:BCC1902
    CAS No.:220662-95-3
  • Varenicline

    Catalog No.:BCC4155
    CAS No.:249296-44-4
  • EVP-6124

    Catalog No.:BCC1566
    CAS No.:550999-75-2
  • LX-1031

    Catalog No.:BCC1712
    CAS No.:945976-76-1

Quality Control of EVP-6124 hydrochloride

Number of papers citing our products

Chemical structure

EVP-6124 hydrochloride

3D structure

Chemical Properties of EVP-6124 hydrochloride

Cas No. 550999-74-1 SDF Download SDF
PubChem ID 46208542 Appearance Powder
Formula C16H18Cl2N2OS M.Wt 357.3
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Encenicline hydrochloride
Solubility DMSO : ≥ 50 mg/mL (139.94 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide;hydrochloride
SMILES C1CN2CCC1C(C2)NC(=O)C3=CC4=C(S3)C(=CC=C4)Cl.Cl
Standard InChIKey OIJYTJGIDVTCFF-ZOWNYOTGSA-N
Standard InChI InChI=1S/C16H17ClN2OS.ClH/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19;/h1-3,8,10,13H,4-7,9H2,(H,18,20);1H/t13-;/m0./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of EVP-6124 hydrochloride

DescriptionErcalcidiol is a metabolite of vitamin D2.

EVP-6124 hydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

EVP-6124 hydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of EVP-6124 hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7988 mL 13.9938 mL 27.9877 mL 55.9754 mL 69.9692 mL
5 mM 0.5598 mL 2.7988 mL 5.5975 mL 11.1951 mL 13.9938 mL
10 mM 0.2799 mL 1.3994 mL 2.7988 mL 5.5975 mL 6.9969 mL
50 mM 0.056 mL 0.2799 mL 0.5598 mL 1.1195 mL 1.3994 mL
100 mM 0.028 mL 0.1399 mL 0.2799 mL 0.5598 mL 0.6997 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on EVP-6124 hydrochloride

EVP-6124 Hydrochloride is a hydrochloride form of EVP-6124. EVP-6124 is partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) that was proved high-affinity in vitro and in vivo. [1]
EVP-6124 was proved to show selectivity for α7 but low-affinity of α4β2 nAChRs in some binding and functional experiments. EVP-6124 had good brain penetration and an adequate exposure time. [1,2]
Co-administration of EVP-6124 and the selective nAChRs antagonist could contribute to the release of DA, ACH, and Glu. This could be used to treat cognitive impairment and possibly other dimensions of psychopathology. Co-administration of donepezil at 0.1 mg/kg, p.o. and EVP-6124 at 0.03 mg/kg proved to be fully restored memory while each of these did not improve memory in this task. [1] Pretreatment with the selective α7 nAChR antagonist, methyllycaconitine (MLA, 1.0 mg/kg), significantly blocked cortical DA and Glu efflux induced by EVP-6124 (0.1 mg/kg). [2,3]
References:
1. Jos Prickaerts, Nick P. van Goethem, et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology, 2012,62 (2): 1099-1110.
2. Mei Huang, Anna R. Felix, et al. Chaya Bhuvaneswaran, Dana Hilt, Gerhard K?nig, Herbert Y. Meltzer, The alpha-7 receptor agonist EVP-6124 increases dopamine and glutamate efflux in rat medial prefrontal cortex and nucleus accumbens. Biochemical Pharmacology, 2011, 82 (8): 1040.
3. Mei Huang, Anna R. Felix, et al. The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens. Psychopharmacology, 2014, 231:4541-4551.

Featured Products
New Products
 

References on EVP-6124 hydrochloride

Development of Automated Patch Clamp Assay for Evaluation of alpha7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch-16.[Pubmed:25880723]

Assay Drug Dev Technol. 2015 Apr;13(3):174-84.

The alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) is an important and challenging target for drug discovery in the area of neuropsychiatric disorders. The current screening for chemicals targeting alpha7 nAChRs is primarily achieved by the use of low-throughput assay two-electrode voltage clamp (TEVC) in nonmammalian Xenopus oocytes. Automated patch clamp system has emerged as an attractive approach compared to conventional electrophysiology. To develop a mammalian cell-based functional assay in an automated electrophysiology system, we in this study generated a stable expression of alpha7 nAChRs in GH3 cells that originated from a rat pituitary tumor cell line and utilized automated QPatch-16 to test a set of tool compounds and chemicals identified as alpha7 agonists by TEVC. For the improvement of evaluating weak or partial alpha7 nAChRs agonists, we achieved enhancement of the signal-to-noise ratio by the addition of a positive allosteric modulator PNU-120596, which only activates alpha7 current in the presence of agonist. This improved assay was further validated by using known alpha7 partial agonists, such as RG3487, EVP-6124, and A-P90. Using this validated assay, we were able to identify a novel agonist 140507C that partially activates alpha7 nAChRs. Taken together, our results validate the use of QPatch-16 for evaluation alpha7 partial agonists, demonstrating its utility as an effective tool for alpha7 ion channel drug discovery.

Description

Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).

Keywords:

EVP-6124 hydrochloride,550999-74-1,Encenicline hydrochloride,Natural Products,Nicotinic Receptor, buy EVP-6124 hydrochloride , EVP-6124 hydrochloride supplier , purchase EVP-6124 hydrochloride , EVP-6124 hydrochloride cost , EVP-6124 hydrochloride manufacturer , order EVP-6124 hydrochloride , high purity EVP-6124 hydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: