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Fuscaxanthone C

CAS# 15404-76-9

Fuscaxanthone C

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Quality Control of Fuscaxanthone C

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Chemical structure

Fuscaxanthone C

3D structure

Chemical Properties of Fuscaxanthone C

Cas No. 15404-76-9 SDF Download SDF
PubChem ID 231412 Appearance Yellow powder
Formula C26H30O6 M.Wt 438.5
Type of Compound Xanthones Storage Desiccate at -20°C
Synonyms 3,6-Dimethylmangostin
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1-hydroxy-3,6,7-trimethoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
SMILES CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(C(=C(C=C3O2)OC)OC)CC=C(C)C)OC)C
Standard InChIKey FCIKYGUVHWZSJV-UHFFFAOYSA-N
Standard InChI InChI=1S/C26H30O6/c1-14(2)8-10-16-18(29-5)12-20-23(24(16)27)25(28)22-17(11-9-15(3)4)26(31-7)21(30-6)13-19(22)32-20/h8-9,12-13,27H,10-11H2,1-7H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Fuscaxanthone C

The fruits of Garcinia mangostana

Biological Activity of Fuscaxanthone C

DescriptionFuscaxanthone C is a natural product from Garcinia mangostana.
In vitro

Cytotoxic constituents from Cratoxylum arborescens.[Pubmed: 15729629 ]

Planta Med. 2005 Feb;71(2):181-3.

A new natural xanthone, 1,3-dihydroxy-6,7-dimethoxy-2,8-diprenylxanthone, together with four known compounds, Fuscaxanthone C, 1,7-dihydroxyxanthone, 3-geranyloxy-6-methyl-1,8-dihydroxyanthraquinone and 2-geranylemodin were isolated from the stem bark of Cratoxylum arborescens (Vahl) Blume.
METHODS AND RESULTS:
The structure elucidations were achieved through spectroscopic analyses. Compounds 1 and 5 showed moderate activity against the human small cell lung cancer NCI-H187 cell line with the IC50 values of 3.69 +/- 1.27 microg/mL and 3.08 +/- 0.73 microg/mL, respectively.

α-mangostin and β-mangostin from Cratoxylum glaucum[Reference: WebLink]

Research Journal of Chemistry & Environment, 2011 , 15 (2) :62-66.

Our continuing interest in xanthones and anthraquinones from the Cratoxylum genus has led us to look at Cratoxylum glaucum. This resulted in the isolation of α-mangostin (1), β-mangostin (2), Fuscaxanthone C (3), 3-geranyloxy-6-methyl-l, 8-dihydroxyanthraquinone (4), β-sitosterol (5), 1, 8-dihydroxy-3-methoxy-6-methylanthraquinone (6), stigmasterol (7), friedelin (8) and betulinic acid (9).
METHODS AND RESULTS:
Structural elucidations of these compounds were achieved by using ID and 2D NMR spectroscopic experiments. Cytotoxic assays indicated that the hexane and ethyl acetate extracts demonstrated cytotoxicity against the MCF7 cancer cell line. Meanwhile, the ethyl acetate and methanol extracts of C. glaucum inhibited the HL-60 cancer cell line activity.

Fuscaxanthone C Dilution Calculator

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Fuscaxanthone C Molarity Calculator

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Preparing Stock Solutions of Fuscaxanthone C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2805 mL 11.4025 mL 22.805 mL 45.61 mL 57.0125 mL
5 mM 0.4561 mL 2.2805 mL 4.561 mL 9.122 mL 11.4025 mL
10 mM 0.2281 mL 1.1403 mL 2.2805 mL 4.561 mL 5.7013 mL
50 mM 0.0456 mL 0.2281 mL 0.4561 mL 0.9122 mL 1.1403 mL
100 mM 0.0228 mL 0.114 mL 0.2281 mL 0.4561 mL 0.5701 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Fuscaxanthone C

Cytotoxic constituents from Cratoxylum arborescens.[Pubmed:15729629]

Planta Med. 2005 Feb;71(2):181-3.

A new natural xanthone, 1,3-dihydroxy-6,7-dimethoxy-2,8-diprenylxanthone, together with four known compounds, Fuscaxanthone C, 1,7-dihydroxyxanthone, 3-geranyloxy-6-methyl-1,8-dihydroxyanthraquinone and 2-geranylemodin were isolated from the stem bark of Cratoxylum arborescens (Vahl) Blume. The structure elucidations were achieved through spectroscopic analyses. Compounds 1 and 5 showed moderate activity against the human small cell lung cancer NCI-H187 cell line with the IC50 values of 3.69 +/- 1.27 microg/mL and 3.08 +/- 0.73 microg/mL, respectively.

Description

Fuscaxanthone C is an xanthone isolated from the stem bark of Garcinia fusca.

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