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Hebeirubescensin H

CAS# 887333-30-4

Hebeirubescensin H

Catalog No. BCN7155----Order now to get a substantial discount!

Product Name & Size Price Stock
Hebeirubescensin H: 5mg $886 In Stock
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Quality Control of Hebeirubescensin H

Number of papers citing our products

Chemical structure

Hebeirubescensin H

3D structure

Chemical Properties of Hebeirubescensin H

Cas No. 887333-30-4 SDF Download SDF
PubChem ID 125115273 Appearance Powder
Formula C20H28O7 M.Wt 380.43
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,2S,5S,8R,9S,10S,11R,15S,16R,18R)-9,10,15,16,18-pentahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one
SMILES CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3O)O)O)O)C
Standard InChIKey BTWFVPFIPDEZTE-XVDSCEKZSA-N
Standard InChI InChI=1S/C20H28O7/c1-8-9-4-5-10-18-11(21)6-7-17(2,3)12(18)15(24)20(26,27-16(18)25)19(10,13(8)22)14(9)23/h9-12,14-16,21,23-26H,1,4-7H2,2-3H3/t9-,10-,11-,12+,14+,15-,16+,18-,19-,20+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Hebeirubescensin H

The leaves of Isodon parvifolius.

Biological Activity of Hebeirubescensin H

DescriptionHebeirubescensin H is a natural product from Isodon parvifolius.

Protocol of Hebeirubescensin H

Structure Identification
Tetrahedron, 2006, 62(20):4941-4947.

Cytotoxic ent-kauranoid derivatives from Isodon rubescens.[Reference: WebLink]


METHODS AND RESULTS:
An extensive study of the diterpenoids produced by the species of Isodon rubescens , has led to the isolation of 12 new ent -kaurane diterpenoids, hebeirubescensin A,Hebeirubescensin B, Hebeirubescensin C,Hebeirubescensin D, Hebeirubescensin E, Hebeirubescensin F, Hebeirubescensin G, Hebeirubescensin H, Hebeirubescensin I, Hebeirubescensin J, Hebeirubescensin K,Hebeirubescensin L ( 1 – 12 ), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells.
CONCLUSIONS:
Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC 50 values of <2.002μM. The structure–activity relationships were discussed.

Hebeirubescensin H Dilution Calculator

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Hebeirubescensin H Molarity Calculator

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Preparing Stock Solutions of Hebeirubescensin H

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6286 mL 13.143 mL 26.286 mL 52.5721 mL 65.7151 mL
5 mM 0.5257 mL 2.6286 mL 5.2572 mL 10.5144 mL 13.143 mL
10 mM 0.2629 mL 1.3143 mL 2.6286 mL 5.2572 mL 6.5715 mL
50 mM 0.0526 mL 0.2629 mL 0.5257 mL 1.0514 mL 1.3143 mL
100 mM 0.0263 mL 0.1314 mL 0.2629 mL 0.5257 mL 0.6572 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Hebeirubescensin H

Cytotoxic ent-kauranoid derivatives from Isodon rubescens.

Tetrahedron, 2006, 62(20):4941-4947.

An extensive study of the diterpenoids produced by the species of Isodon rubescens , has led to the isolation of 12 new ent -kaurane diterpenoids, hebeirubescensin A,Hebeirubescensin B, Hebeirubescensin C,Hebeirubescensin D, Hebeirubescensin E, Hebeirubescensin F, Hebeirubescensin G, Hebeirubescensin H, Hebeirubescensin I, Hebeirubescensin J, Hebeirubescensin K,Hebeirubescensin L ( 1 – 12 ), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC 50 values of <2.002μM. The structure–activity relationships were discussed.

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