Heleurine

CAS# 488-00-6

Heleurine

Catalog No. BCN1953----Order now to get a substantial discount!

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Quality Control of Heleurine

Number of papers citing our products

Chemical structure

Heleurine

3D structure

Chemical Properties of Heleurine

Cas No. 488-00-6 SDF Download SDF
PubChem ID 10259 Appearance Powder
Formula C16H27NO4 M.Wt 297.39
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,6,7,8-tetrahydro-3H-pyrrolizin-1-ylmethyl 2-hydroxy-2-(1-methoxyethyl)-3-methylbutanoate
SMILES CC(C)C(C(C)OC)(C(=O)OCC1=CCN2C1CCC2)O
Standard InChIKey AORFDVNAPHMKAU-UHFFFAOYSA-N
Standard InChI InChI=1S/C16H27NO4/c1-11(2)16(19,12(3)20-4)15(18)21-10-13-7-9-17-8-5-6-14(13)17/h7,11-12,14,19H,5-6,8-10H2,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Heleurine

The herbs of Heliotropium indicum L.

Biological Activity of Heleurine

Description1. Heleurine, platyphylline, supinine and cynaustraline are more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine.
TargetsAChR

Heleurine Dilution Calculator

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Heleurine Molarity Calculator

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Preparing Stock Solutions of Heleurine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3626 mL 16.8129 mL 33.6259 mL 67.2518 mL 84.0647 mL
5 mM 0.6725 mL 3.3626 mL 6.7252 mL 13.4504 mL 16.8129 mL
10 mM 0.3363 mL 1.6813 mL 3.3626 mL 6.7252 mL 8.4065 mL
50 mM 0.0673 mL 0.3363 mL 0.6725 mL 1.345 mL 1.6813 mL
100 mM 0.0336 mL 0.1681 mL 0.3363 mL 0.6725 mL 0.8406 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Heleurine

Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.[Pubmed:5579465]

Br J Pharmacol. 1971 Apr;41(4):683-90.

1. Eleven pyrrolizidine alkaloids have been tested on the isolated guinea-pig ileum preparation.2. Platyphylline, supinine, Heleurine and cynaustraline were more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine. Their anticholinergic activity appeared to involve a competitive mechanism.3. Lasiocarpine, monocrotaline, spectabiline, sarracine, 7-angelylheliotridine, heliotrine and senecionine had similar antagonistic potencies against responses to both acetylcholine and histamine.4. The alkaloids had no appreciable activity as antagonists of acetylcholine in the isolated toad rectus abdominis preparation.5. These results are discussed with respect to interactions of the alkaloids at receptor sites involved in anticholinergic activity at the muscarinic receptor.

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