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Hydralazine HCl

CAS# 304-20-1

Hydralazine HCl

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Chemical structure

Hydralazine HCl

3D structure

Chemical Properties of Hydralazine HCl

Cas No. 304-20-1 SDF Download SDF
PubChem ID 9351 Appearance Powder
Formula C8H9ClN4 M.Wt 196.64
Type of Compound N/A Storage Desiccate at -20°C
Solubility H2O : 25 mg/mL (127.14 mM; Need ultrasonic)
Chemical Name phthalazin-1-ylhydrazine;hydrochloride
SMILES [H+].[Cl-].NNc1nncc2ccccc12
Standard InChIKey ZUXNZUWOTSUBMN-UHFFFAOYSA-N
Standard InChI InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Hydralazine HCl Dilution Calculator

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Hydralazine HCl Molarity Calculator

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Preparing Stock Solutions of Hydralazine HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.0854 mL 25.4272 mL 50.8544 mL 101.7087 mL 127.1359 mL
5 mM 1.0171 mL 5.0854 mL 10.1709 mL 20.3417 mL 25.4272 mL
10 mM 0.5085 mL 2.5427 mL 5.0854 mL 10.1709 mL 12.7136 mL
50 mM 0.1017 mL 0.5085 mL 1.0171 mL 2.0342 mL 2.5427 mL
100 mM 0.0509 mL 0.2543 mL 0.5085 mL 1.0171 mL 1.2714 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Hydralazine HCl

Relaxing effect of CEDO 8956 and hydralazine HCl in cultured smooth muscle cells versus pericytes: a preliminary study.[Pubmed:12022017]

Klin Monbl Augenheilkd. 2002 Apr;219(4):277-80.

BACKGROUND: It hs been reported that some glaucoma patients have deficient endothelial nitric oxide production. The effect of the presupposed nitrovasodilators CEDO 8956 and hydralazine hydrochloride (HCl) on bovine retinal microcirculation pericytes and ophthalmic artery smooth muscle cells are investigated. METHODS: Cells were cultured on silicone membranes and their contractile tone observed by phase contrast inverted microscopy before and after exposure by fluid exchange to different drugs at various concentrations. Experiments were conducted with pericytes in the absence (control) or in the presence (10 nM - 0.1 mM) of CEDO 8956, Hydralazine HCl, or sodium nitroprusside (SNP). Experiments were conducted with smooth muscle cells in the absence (control) or in the presence (0.1 mM) of CEDO 8956, or Hydralazine HCl. RESULTS: In comparison to control (- 0.56 +/- 10 %), pericytes were significantly relaxed by SNP (100 +/- 0 %, p < 0.001), but not by CEDO 8956 (9.2 +/- 15.4 %) or Hydralazine HCl (20.6 +/- 4.4 %). In comparison to control (1.64 +/- 5.3 %), smooth muscle cells were significantly relaxed by CEDO 8956 (46.2 +/- 12.4 %, p < 0.05) and Hydralazine HCl (54.9 +/- 9.1 %, p < 0.001). CONCLUSIONS: These results suggest a possible heterogeneity between cultured bovine microcirculation pericytes and ophthalmic artery vascular smooth muscle cells in the relaxing response to CEDO 8956 and Hydralazine HCl. Apparently, these two drugs might not be first choice candidates in order to attempt to try to selectively improve circulation in the retina or the optic nerve head capillary network.

Cardiovascular effects of hydralazine HCl administration in horses.[Pubmed:3395006]

Am J Vet Res. 1988 May;49(5):618-21.

Six standing awake adult horses were instrumented for measurement of mean arterial, central venous, and pulmonary arterial blood pressures (mm of Hg), thermodilution cardiac output (ml/kg/min), and pulmonary arterial blood temperature (C). Total peripheral resistance was calculated from these values. Base-line data were accumulated, and a single dose of Hydralazine HCl (0.5 mg/kg) was administered IV. Horses were monitored for 420 minutes after hydralazine administration. Mean arterial and central venous blood pressures did not change from the base-line values. Cardiac output and heart rate were increased above base-line values for 260 minutes. Total peripheral resistance was decreased for 240 minutes. Pulmonary arterial blood temperature was decreased for 60 minutes after drug administration. Mean pulmonary arterial pressure relative to the base-line mean was intermittently decreased during the study. Intravenously administered Hydralazine HCl appears to be an effective vasodilator, with moderate duration of action in horses.

Description

Hydralazine hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.

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