Ilicic acid

CAS# 4586-68-9

Ilicic acid

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Ilicic acid: 5mg $638 In Stock
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Quality Control of Ilicic acid

Number of papers citing our products

Chemical structure

Ilicic acid

3D structure

Chemical Properties of Ilicic acid

Cas No. 4586-68-9 SDF Download SDF
PubChem ID 386212 Appearance Powder
Formula C15H24O3 M.Wt 252.4
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-[(4aR,8R)-8-hydroxy-4a,8-dimethyl-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid
SMILES CC12CCCC(C1CC(CC2)C(=C)C(=O)O)(C)O
Standard InChIKey FXKCXGBBUBCRPU-BBNOBNGHSA-N
Standard InChI InChI=1S/C15H24O3/c1-10(13(16)17)11-5-8-14(2)6-4-7-15(3,18)12(14)9-11/h11-12,18H,1,4-9H2,2-3H3,(H,16,17)/t11?,12?,14-,15-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ilicic acid

The bark of Laggera pterodonta

Biological Activity of Ilicic acid

In vitro

Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity.[Pubmed: 22986291]

Fitoterapia. 2012 Dec;83(8):1590-7.


METHODS AND RESULTS:
Three new germacrane sesquiterpenes (1), (2), (3), along with eleven known sesquiterpenes, namely, tirotundin-3-O-methyl ether (4), deacetylvguiestin (5), 1β-hydroxydiversifolin-3-O-methyl ether (6), tagitinin C (7), 1β-hydroxytirotundin-3-O-methyl ether (8), 1β-hydroxytirotundin-1,3-O-dimethyl ether (9), tagitinin F-3-O-methyl ether (10), tagitinin F (11), tagitinin A (12), 3β-acetoxy-4α-hydroxyeduesm-11(13)-en-12-oic acid (13) and Ilicic acid (14) were isolated from the aerial parts of Tithonia diversifolia. Their structures were established by spectroscopic analysis, while the relative configuration of compound 1 was confirmed by X-ray diffraction analysis. In addition, compounds 1-14 were evaluated in vitro for their anti-hyperglycemic activity by glucose uptake in 3T3-L1 adipocytes.
CONCLUSIONS:
It was found that 10μg/mL 1, 3, 6 and 8 could significantly increase glucose uptake without significant toxic effects.

Ilicic acid Dilution Calculator

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Ilicic acid Molarity Calculator

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Preparing Stock Solutions of Ilicic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.962 mL 19.8098 mL 39.6197 mL 79.2393 mL 99.0491 mL
5 mM 0.7924 mL 3.962 mL 7.9239 mL 15.8479 mL 19.8098 mL
10 mM 0.3962 mL 1.981 mL 3.962 mL 7.9239 mL 9.9049 mL
50 mM 0.0792 mL 0.3962 mL 0.7924 mL 1.5848 mL 1.981 mL
100 mM 0.0396 mL 0.1981 mL 0.3962 mL 0.7924 mL 0.9905 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ilicic acid

Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity.[Pubmed:22986291]

Fitoterapia. 2012 Dec;83(8):1590-7.

Three new germacrane sesquiterpenes (1), (2), (3), along with eleven known sesquiterpenes, namely, tirotundin-3-O-methyl ether (4), deacetylvguiestin (5), 1beta-hydroxydiversifolin-3-O-methyl ether (6), tagitinin C (7), 1beta-hydroxytirotundin-3-O-methyl ether (8), 1beta-hydroxytirotundin-1,3-O-dimethyl ether (9), tagitinin F-3-O-methyl ether (10), tagitinin F (11), tagitinin A (12), 3beta-acetoxy-4alpha-hydroxyeduesm-11(13)-en-12-oic acid (13) and Ilicic acid (14) were isolated from the aerial parts of Tithonia diversifolia. Their structures were established by spectroscopic analysis, while the relative configuration of compound 1 was confirmed by X-ray diffraction analysis. In addition, compounds 1-14 were evaluated in vitro for their anti-hyperglycemic activity by glucose uptake in 3T3-L1 adipocytes. It was found that 10mug/mL 1, 3, 6 and 8 could significantly increase glucose uptake without significant toxic effects.

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