Lasiocarpine

CAS# 303-34-4

Lasiocarpine

Catalog No. BCN2001----Order now to get a substantial discount!

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Quality Control of Lasiocarpine

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Chemical structure

Lasiocarpine

3D structure

Chemical Properties of Lasiocarpine

Cas No. 303-34-4 SDF Download SDF
PubChem ID 6325507 Appearance White powder
Formula C21H33NO7 M.Wt 411.49
Type of Compound Alkaloids Storage Desiccate at -20°C
Synonyms 7-Angelyleuropine; Europine 7-angelate
Solubility Soluble in chloroform, ethanol and methanol; sparingly soluble in water
Chemical Name [(7S,8R)-7-[(Z)-2-methylbut-2-enoyl]oxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2R)-2,3-dihydroxy-2-[(1R)-1-methoxyethyl]-3-methylbutanoate
SMILES CC=C(C)C(=O)OC1CCN2C1C(=CC2)COC(=O)C(C(C)OC)(C(C)(C)O)O
Standard InChIKey QHOZSLCIKHUPSU-GTZNJGJUSA-N
Standard InChI InChI=1S/C21H33NO7/c1-7-13(2)18(23)29-16-9-11-22-10-8-15(17(16)22)12-28-19(24)21(26,14(3)27-6)20(4,5)25/h7-8,14,16-17,25-26H,9-12H2,1-6H3/b13-7-/t14-,16+,17-,21+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lasiocarpine

1 Symphytum sp.

Biological Activity of Lasiocarpine

Description1. Lasiocarpine can produce liver damage. 2. Lasiocarpine has antimitotic action. 3. Lasiocarpine has hepatocarcinogenicity, the effect can be better explained by its strong selection (promotion) influence on initiated hepatocytes, rather than by its very weak initiating activity.
TargetsDNA/RNA Synthesis

Lasiocarpine Dilution Calculator

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Lasiocarpine Molarity Calculator

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Preparing Stock Solutions of Lasiocarpine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4302 mL 12.151 mL 24.3019 mL 48.6039 mL 60.7548 mL
5 mM 0.486 mL 2.4302 mL 4.8604 mL 9.7208 mL 12.151 mL
10 mM 0.243 mL 1.2151 mL 2.4302 mL 4.8604 mL 6.0755 mL
50 mM 0.0486 mL 0.243 mL 0.486 mL 0.9721 mL 1.2151 mL
100 mM 0.0243 mL 0.1215 mL 0.243 mL 0.486 mL 0.6075 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lasiocarpine

Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine.[Pubmed:2861891]

Cancer Res. 1985 Aug;45(8):3726-34.

The biological mechanisms by which pyrrolizidine alkaloids contribute to initiation and nodule selection (promotion) steps in hepatic carcinogenesis were studied in male Fischer 344 rats. Lasiocarpine at single or double dosages (up to 80 mumol/kg) delayed hepatic regeneration for at least 8 weeks after partial hepatectomy (PH). This regimen of Lasiocarpine and PH had a strong selective influence on the growth of gamma-glutamyltranspeptidase (gamma-GT)-positive hepatocyte nodules in rats previously initiated with diethylnitrosamine. However, both Lasiocarpine (up to 80 mumol/kg) and senecionine (up to 160 mumol/kg) were inactive as initiators of gamma-GT-positive nodules in rats exposed to a similar selection regimen consisting of 2-acetylaminofluorene and PH. When Lasiocarpine or senecionine was given 12 h after PH, very few nodules were initiated. Lasiocarpine pretreatments reduced the initiating activity of diethylnitrosamine and N-nitrosomethylurea in rats subsequently selected with 2-acetylaminofluorene and PH. Resistant nodules selected with Lasiocarpine had the typical resistant nodule phenotype (positive for gamma-GT and epoxide hydrolase) and also lacked pyrrolizidine alkaloid-induced megalocytosis. Lasiocarpine treatment also resulted in small regenerative nodular proliferations of hepatocytes that were distinct from resistant nodules because they were negative for gamma-GT and epoxide hydrolase and unrelated to diethylnitrosamine pretreatments. These studies suggest that the hepatocarcinogenicity of pyrrolizidine alkaloids can be better explained by their strong selection (promotion) influence on initiated hepatocytes, rather than by their very weak initiating activity.

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