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Ledipasvir acetone

CAS# 1441674-54-9

Ledipasvir acetone

Catalog No. BCC4046----Order now to get a substantial discount!

Product Name & Size Price Stock
Ledipasvir acetone: 5mg $161 In Stock
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Chemical structure

Ledipasvir acetone

3D structure

Chemical Properties of Ledipasvir acetone

Cas No. 1441674-54-9 SDF Download SDF
PubChem ID 78357793 Appearance Powder
Formula C52H60F2N8O7 M.Wt 947.08
Type of Compound N/A Storage Desiccate at -20°C
Synonyms GS-5885 acetone
Solubility DMSO : ≥ 39 mg/mL (41.18 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name methyl N-[(2S)-1-[(6S)-6-[5-[9,9-difluoro-7-[2-[(1S,2S,4R)-3-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-3-azabicyclo[2.2.1]heptan-2-yl]-3H-benzimidazol-5-yl]fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl]carbamate;propan-2-one
SMILES CC(C)C(C(=O)N1CC2(CC2)CC1C3=NC=C(N3)C4=CC5=C(C=C4)C6=C(C5(F)F)C=C(C=C6)C7=CC8=C(C=C7)N=C(N8)C9C1CCC(C1)N9C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC.CC(=O)C
Standard InChIKey FJPWYOHJVGOKNZ-NDANSHMASA-N
Standard InChI InChI=1S/C49H54F2N8O6.C3H6O/c1-24(2)39(56-46(62)64-5)44(60)58-23-48(15-16-48)21-38(58)42-52-22-37(55-42)28-9-13-32-31-12-8-26(18-33(31)49(50,51)34(32)19-28)27-10-14-35-36(20-27)54-43(53-35)41-29-7-11-30(17-29)59(41)45(61)40(25(3)4)57-47(63)65-6;1-3(2)4/h8-10,12-14,18-20,22,24-25,29-30,38-41H,7,11,15-17,21,23H2,1-6H3,(H,52,55)(H,53,54)(H,56,62)(H,57,63);1-2H3/t29-,30+,38-,39-,40-,41-;/m0./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Ledipasvir acetone

DescriptionLedipasvir acetone is the active pharmaceutical ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.In Vitro:Ledipasvir acetone is considered the active pharmaceutical ingredient, which is converted to Ledipasvir spray-dried dispersion, an amorphous free base.

Ledipasvir acetone Dilution Calculator

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Ledipasvir acetone Molarity Calculator

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Preparing Stock Solutions of Ledipasvir acetone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.0559 mL 5.2794 mL 10.5588 mL 21.1175 mL 26.3969 mL
5 mM 0.2112 mL 1.0559 mL 2.1118 mL 4.2235 mL 5.2794 mL
10 mM 0.1056 mL 0.5279 mL 1.0559 mL 2.1118 mL 2.6397 mL
50 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.4224 mL 0.5279 mL
100 mM 0.0106 mL 0.0528 mL 0.1056 mL 0.2112 mL 0.264 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Ledipasvir acetone

Ledipasvir (GS5885) acetone is an inhibitor of the hepatitis C virus NS5A protein, which is an experimental drug for the treatment of hepatitis C.

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Description

Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.

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