Lobelanine

CAS# 579-21-5

Lobelanine

Catalog No. BCN2156----Order now to get a substantial discount!

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Quality Control of Lobelanine

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Chemical structure

Lobelanine

3D structure

Chemical Properties of Lobelanine

Cas No. 579-21-5 SDF Download SDF
PubChem ID 442647 Appearance Powder
Formula C22H25NO2 M.Wt 335.44
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-[(2S,6R)-1-methyl-6-phenacylpiperidin-2-yl]-1-phenylethanone
SMILES CN1C(CCCC1CC(=O)C2=CC=CC=C2)CC(=O)C3=CC=CC=C3
Standard InChIKey IDEMKXUAULKYJV-BGYRXZFFSA-N
Standard InChI InChI=1S/C22H25NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-20H,8,13-16H2,1H3/t19-,20+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Lobelanine

TargetsAChR

Lobelanine Dilution Calculator

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Lobelanine Molarity Calculator

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Preparing Stock Solutions of Lobelanine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9812 mL 14.9058 mL 29.8116 mL 59.6232 mL 74.529 mL
5 mM 0.5962 mL 2.9812 mL 5.9623 mL 11.9246 mL 14.9058 mL
10 mM 0.2981 mL 1.4906 mL 2.9812 mL 5.9623 mL 7.4529 mL
50 mM 0.0596 mL 0.2981 mL 0.5962 mL 1.1925 mL 1.4906 mL
100 mM 0.0298 mL 0.1491 mL 0.2981 mL 0.5962 mL 0.7453 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lobelanine

Lobelia chinensis: chemical constituents and anticancer activity perspective.[Pubmed:24636059]

Chin J Nat Med. 2014 Feb;12(2):103-7.

Research has demonstrated that many chemical constituents dominated by piperidine alkaloids and flavonoids, such as lobelanidine, lobeline, and Lobelanine, have been obtained from Lobelia chinensis Lour. Experimental studies and clinical applications have also indicated that L. chinensis possesses a number of pharmacological activities (e.g., diuretic, choleretic, breathing excitement, anti-venom, anti-bacterial, and anticancer). This paper focuses on the properties, chemical constituents, and anticancer activity of L. chinensis to clarify the connection among them, and identify the active anticancer compounds. This work serves as the foundation for further research and development of L. chinensis.

Synthesis of (-)-lobeline via enzymatic desymmetrization of lobelanidine.[Pubmed:19217305]

Bioorg Med Chem. 2009 Mar 1;17(5):1837-9.

The bioactive alkaloid (-)-lobeline was synthesized via the stereoselective acylation (desymmetrization) of meso-lobelanidine by vinyl acetate in the presence of Candida antarctica lipase B.

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