MacaranginCAS# 129385-65-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 129385-65-5 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Yellow powder |
| Formula | C25H26O6 | M.Wt | 422.47 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Macarangin Dilution Calculator
Macarangin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.367 mL | 11.8352 mL | 23.6703 mL | 47.3406 mL | 59.1758 mL |
| 5 mM | 0.4734 mL | 2.367 mL | 4.7341 mL | 9.4681 mL | 11.8352 mL |
| 10 mM | 0.2367 mL | 1.1835 mL | 2.367 mL | 4.7341 mL | 5.9176 mL |
| 50 mM | 0.0473 mL | 0.2367 mL | 0.4734 mL | 0.9468 mL | 1.1835 mL |
| 100 mM | 0.0237 mL | 0.1184 mL | 0.2367 mL | 0.4734 mL | 0.5918 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 5,5'-Oxybis(pyrrolidin-2-one)
Catalog No.:BCX0173
CAS No.:73123-79-2
- (-)-Byakangelicin
Catalog No.:BCX0172
CAS No.:23517-02-4
- (+)-3-Hydroxy-p-menth-1-en-6-one
Catalog No.:BCX0171
CAS No.:120850-08-0
- Leonuriside A
Catalog No.:BCX0170
CAS No.:121748-12-7
- threo-Guaiacylglycerol β-dihydroconiferyl ether
Catalog No.:BCX0169
CAS No.:135820-78-9
- Justicidin A
Catalog No.:BCX0168
CAS No.:25001-57-4
- 3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid
Catalog No.:BCX0167
CAS No.:469895-08-7
- Pyrolone B
Catalog No.:BCX0166
CAS No.:1014978-30-3
- Gerardianin D
Catalog No.:BCX0165
CAS No.:2036276-69-2
- Retrofractamide C
Catalog No.:BCX0164
CAS No.:96386-33-3
- Justicidinoside C
Catalog No.:BCX0163
CAS No.:177912-23-1
- Massonianoside A
Catalog No.:BCX0162
CAS No.:623945-11-9
- 3-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol
Catalog No.:BCX0175
CAS No.:27391-18-0
- Anthriscifoldine B
Catalog No.:BCX0176
CAS No.:1158213-52-5
- α-Cembrenediol
Catalog No.:BCX0177
CAS No.:57605-80-8
- β-Cembrenediol
Catalog No.:BCX0178
CAS No.:57605-81-9
- Vesuvianic acid
Catalog No.:BCX0179
CAS No.:63090-99-3
- N-Tetracosanoyltyramine
Catalog No.:BCX0180
CAS No.:113122-70-6
- Lycoctonine
Catalog No.:BCX0181
CAS No.:26000-17-9
- 2',4',6'-Trihydroxydihydrochalcone
Catalog No.:BCX0182
CAS No.:1088-08-0
- Powelline
Catalog No.:BCX0183
CAS No.:7363-25-9
- Amentoflavone 7'',4'''-dimethyl ether
Catalog No.:BCX0184
CAS No.:34293-14-6
- 1-O-p-Coumaroyl-3-O-feruloylglycerol
Catalog No.:BCX0185
CAS No.:108026-21-7
- Gnemontanin F
Catalog No.:BCX0186
CAS No.:2210293-19-7
Antinociceptive Activity of Macaranga denticulata Muell. Arg. (Family: Euphorbiaceae): In Vivo and In Silico Studies.[Pubmed:29194388]
Medicines (Basel). 2017 Dec 1;4(4):88.
Background: The present study was conducted to investigate the antinociceptive activity of methanol extract of Macaranga denticulata (Met.MD) in an animal model, followed by molecular docking analysis. Methods: Antinociceptive activity was determined by acetic acid-induced writhing and formalin-induced licking test in mice. Then, molecular docking study was performed to identify compounds having maximum activity against the COX-1 enzyme using Schrodinger Maestro (version 10.1) to determine docking fitness. Results: A preliminary phytochemical analysis of Met.MD revealed that it contained alkaloids, carbohydrates, phenols, flavonoids, tannins, and terpenoids. Met.MD exhibited a dose-dependent and statistically significant antinociceptive activity in the acetic acid and formalin test at the doses of 200 and 400 mg/kg. In addition, our docking study showed that Macarangin had the best fitness score of -5.81 with COX-1 enzyme among six major compounds of M. denticulata. Conclusions: Results of the present study confirmed the potential antinociceptive activity of M. denticulata leaf extract in both in vivo and in silico models.
Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata.[Pubmed:26791751]
Nat Prod Bioprospect. 2016 Feb;6(1):25-30.
Three new C-methylated and isoprenylated chalcone derivatives, dentichalcones A-C (1-3), together with six known compounds (4-9), were isolated from the twigs and leaves of Macaranga denticulata. Their structures were elucidated by spectroscopic analysis, including 1D, 2D NMR, and MS data. The known compounds, (2E)-1-(5,7-dihydroxy-2,2,6-trimethyl-2H-benzopyran-8-yl)-3-(4-methoxyphenyl)-2-propen-1-one (4), (2E)-1-(5,7-dihydroxy-2,2-dimethyl-2H-benzopyran-8-yl)-3-phenyl-2-propen-1-one (5), laxichalcone (6), Macarangin (7), bonanniol A (8), and bonannione A (9), showed inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) in vitro. Three new C-methylated and isoprenylated chalcone derivatives, dentichalcones A-C (1-3), together with six known compounds, were isolated from the twigs and leaves of Macaranga denticulata. Some compounds showed inhibitory activities against PTP1B in vitro.
Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei.[Pubmed:26662866]
Phytochem Anal. 2016 Mar-Apr;27(2):107-15.
INTRODUCTION: A previous study showed the unique character of Nigerian red propolis from Rivers State, Nigeria (RSN), with regards to chemical composition and activity against Trypanosoma brucei in comparison with other African propolis. OBJECTIVE: To carry out fractionation and biological testing of Nigerian propolis in order to isolate compounds with anti-trypanosomal activity. To compare the composition of the RSN propolis with the composition of Brazilian red propolis. METHODOLOGY: Profiling was carried out using HPLC-UV-ELSD and HPLC-Orbitrap-FTMS on extracts of two samples collected from RSN with data extraction using MZmine software. Isolation was carried out by normal phase and reversed phase MPLC. Elucidation of the compounds with a purity > 95% was performed by 1D/2D NMR HRMS and HRLC-MS(n) . RESULTS: Ten phenolic compounds were isolated or in the case of liquiritigenin partially purified. Data for nine of these correlated with literature reports of known compounds i.e. one isoflavanone, calycosin (1); two flavanones, liquiritigenin (2) and pinocembrin (5); an isoflavan, vestitol (3); a pterocarpan, medicarpin (4); two prenylflavanones, 8-prenylnaringenin (7) and 6-prenylnaringenin (8); and two geranyl flavonoids, propolin D (9) and Macarangin (10). The tenth was elucidated as a previously undescribed dihydrobenzofuran (6). The isolated compounds were tested against Trypanosoma brucei and displayed moderate to high activity. Some of the compounds tested had similar activity against wild type T. brucei and two strains displaying pentamidine resistance. CONCLUSION: Nigerian propolis from RSN has some similarities with Brazilian red propolis. The propolis displayed anti-trypanosomal activity at a potentially useful level.
New biologically active compounds from Kenyan propolis.[Pubmed:20079813]
Fitoterapia. 2010 Sep;81(6):509-14.
From propolis samples from Kenya, two new arylnaphtalene lignans were isolated, tetrahydrojusticidin B 1 and 6-methoxydiphyllin 2, along with four known phenolic compounds 5-8, found for the first time in propolis. The structures of the compounds were elucidated based on their spectral properties. The geranylstilbenes 7 and 8 demonstrated antibacterial activity against S. aureus, and the geranylflavon Macarangin 6 possessed antiradical activity against DPPH radicals.
