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Marbofloxacin hydrochloride

CAS# 115551-26-3

Marbofloxacin hydrochloride

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Chemical structure

Marbofloxacin hydrochloride

3D structure

Chemical Properties of Marbofloxacin hydrochloride

Cas No. 115551-26-3 SDF Download SDF
PubChem ID 14576609 Appearance Powder
Formula C17H20ClFN4O4 M.Wt 398.82
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO
SMILES CN1CCN(CC1)C2=C(C=C3C4=C2OCN(N4C=C(C3=O)C(=O)O)C)F.Cl
Standard InChIKey OCRYFLKYXNBUEY-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H19FN4O4.ClH/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25;/h7-8H,3-6,9H2,1-2H3,(H,24,25);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Marbofloxacin hydrochloride

DescriptionMarbofloxacin hydrochloride is a potent antibiotic of which depends upon its inhibition of DNA-gyrase. Target: DNA-gyrase Marbofloxacin hydrochloride is a third-generation fluoroquinolone for veterinary use, the antimicrobial of which depends upon its inhibition of DNA-gyrase and topoisomerase IV. With a broad spectrum bactericidal activity and good efficacy, marbofloxacin hydrochloride is indicated for dermatological, respiratory and urinary tract infections due to both Gram-positive and Gram-negative bacteria and Mycoplasma [1]. Administration of Marbofloxacin hydrochloride at 6 mg/kg once daily for 7 days in a Staphylococcus aureus infection in tissue cages in ponies is not effective for the elimination of S. aureus infections from secluded sites [2]. The pharmacokinetic properties of marbofloxacin hydrochloride were investigated in 6 horses after i.v., subcutaneous and oral administration of a single dose of 2 mg/kg bwt and the minimal inhibitory concentrations (MIC) assessed for bacteria isolated from equine infectious pathologies. The clearance of marbofloxacin hydrochloride was mean +/- s.d. 0.25 +/- 0.05 l/kg/h and the terminal half-life 756 +/- 1.99 h. The marbofloxacin hydrochloride absolute bioavailabilities after subcutaneous and oral administration were 98 +/- 11% and 62 +/- 8%, respectively. Considering the breakpoint values of efficacy indices for fluoroquinolones, a marbofloxacin hydrochloride dosage regimen of 2 mg/kg bwt/24 h by i.v., subcutaneous or oral routes was more appropriate for enterobacteriaceae than for S. aureus [3]. Toxicity: cramps; vomiting; anorexia; soft stools; diarrhoea

References:
[1]. Shen J, et al. Marbofloxacin. Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o998-9. [2]. Voermans M, et al. Clinical efficacy of intravenous administration of marbofloxacin in a Staphylococcus aureus infection in tissue cages in ponies. J Vet Pharmacol Ther. 2006 Dec;29(6):555-60. [3]. Bousquet-Melou A, et al. Pharmacokinetics of marbofloxacin in horses. Equine Vet J. 2002 Jul;34(4):366-72.

Marbofloxacin hydrochloride Dilution Calculator

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Marbofloxacin hydrochloride Molarity Calculator

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Preparing Stock Solutions of Marbofloxacin hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5074 mL 12.537 mL 25.074 mL 50.1479 mL 62.6849 mL
5 mM 0.5015 mL 2.5074 mL 5.0148 mL 10.0296 mL 12.537 mL
10 mM 0.2507 mL 1.2537 mL 2.5074 mL 5.0148 mL 6.2685 mL
50 mM 0.0501 mL 0.2507 mL 0.5015 mL 1.003 mL 1.2537 mL
100 mM 0.0251 mL 0.1254 mL 0.2507 mL 0.5015 mL 0.6268 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Marbofloxacin hydrochloride

Marbofloxacin hydrochloride is a potent antibiotic of which depends upon its inhibition of DNA-gyrase.

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Description

Marbofloxacin hydrochloride is a potent antibiotic of which depends upon its inhibition of DNA-gyrase.

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