Medicagenic acid

CAS# 599-07-5

Medicagenic acid

Catalog No. BCN3893----Order now to get a substantial discount!

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Quality Control of Medicagenic acid

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Chemical structure

Medicagenic acid

3D structure

Chemical Properties of Medicagenic acid

Cas No. 599-07-5 SDF Download SDF
PubChem ID 65048 Appearance White powder
Formula C30H46O6 M.Wt 502.68
Type of Compound Triterpenoids Storage Desiccate at -20°C
Synonyms Castanogenin
Solubility Soluble in methan
Chemical Name (2S,3R,4S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-2,3-dihydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylic acid
SMILES CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C(=O)O)O)O)C)C)C2C1)C)C(=O)O)C
Standard InChIKey IDGXIXSKISLYAC-WNTKNEGGSA-N
Standard InChI InChI=1S/C30H46O6/c1-25(2)11-13-30(24(35)36)14-12-27(4)17(18(30)15-25)7-8-20-26(3)16-19(31)22(32)29(6,23(33)34)21(26)9-10-28(20,27)5/h7,18-22,31-32H,8-16H2,1-6H3,(H,33,34)(H,35,36)/t18-,19-,20+,21+,22-,26+,27+,28+,29-,30-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Medicagenic acid

The herbs of Medicago sativa

Biological Activity of Medicagenic acid

Description1. Medicagenic acid derivatives exhibit potent fungistatic effects against several plant pathogens and human dermatophytes. 2. Medicagenic acid, the factor responsible for hemolytic activity of lucerne saponins.
TargetsAntifection

Medicagenic acid Dilution Calculator

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Medicagenic acid Molarity Calculator

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Preparing Stock Solutions of Medicagenic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9893 mL 9.9467 mL 19.8934 mL 39.7867 mL 49.7334 mL
5 mM 0.3979 mL 1.9893 mL 3.9787 mL 7.9573 mL 9.9467 mL
10 mM 0.1989 mL 0.9947 mL 1.9893 mL 3.9787 mL 4.9733 mL
50 mM 0.0398 mL 0.1989 mL 0.3979 mL 0.7957 mL 0.9947 mL
100 mM 0.0199 mL 0.0995 mL 0.1989 mL 0.3979 mL 0.4973 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Medicagenic acid

Saponins as antimycotic agents: glycosides of medicagenic acid.[Pubmed:8957322]

Adv Exp Med Biol. 1996;404:535-46.

The continuous search for new antimycotic drugs is a consequence of the broad use of immunosuppressive drugs and broad-spectrum antibiotics, high number of AIDS patients, and widespread dermatophyte infections. The concern with increased resistance due to widespread and prolonged antifungal treatment, particularly with azoles, is noteworthy. Our efforts were focused on Medicagenic acid derivatives isolated from alfalfa and on semisynthetic ones. In general, these materials exhibited potent fungistatic effects against several plant pathogens and human dermatophytes. Furthermore, they were fungicidal against medically important yeasts, showing a most impressive activity against Cryptococcus neoformans, the minimal fungicidal concentration (MFC) value of the gluco derivative of Medicagenic acid, compound G2, is 4 micrograms/ml. The mode of action as well as the structure-activity relationships of these compounds were studied. Compound G2, when applied topically, was effective in curing skin lesions of guinea pigs infected with the dermatophyte Trichophyton mentagrophytes and good skin tolerance to the drug was noted. Furthermore, it had a life-prolonging effect on mice infected with C. neoformans and recently, liposomes containing compound G2 were used efficiently as a drug delivery system in treatment of murine cryptococcosis and candidiosis.

Description

Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra L, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes. Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE.

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