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Methimepip dihydrobromide

Extremely selective H3 agonist CAS# 817636-54-7

Methimepip dihydrobromide

Catalog No. BCC7524----Order now to get a substantial discount!

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Methimepip dihydrobromide: 5mg $92 In Stock
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Chemical structure

Methimepip dihydrobromide

3D structure

Chemical Properties of Methimepip dihydrobromide

Cas No. 817636-54-7 SDF Download SDF
PubChem ID 11313836 Appearance Powder
Formula C10H19Br2N3 M.Wt 341.09
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in water
Chemical Name 4-(1H-imidazol-5-ylmethyl)-1-methylpiperidine;dihydrobromide
SMILES CN1CCC(CC1)CC2=CN=CN2.Br.Br
Standard InChIKey XTJPHXJFOFOXJG-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H17N3.2BrH/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10;;/h7-9H,2-6H2,1H3,(H,11,12);2*1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Methimepip dihydrobromide

DescriptionExtremely selective histamine H3 receptor agonist (pKi values are 9.0, 5.7, < 5.0 and < 5.0 for hH3, hH4, hH1 and hH2 receptors respectively). Potently inhibits EFS-evoked contractions of guinea pig ileum (pD2 = 8.26).

Methimepip dihydrobromide Dilution Calculator

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Methimepip dihydrobromide Molarity Calculator

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Preparing Stock Solutions of Methimepip dihydrobromide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9318 mL 14.6589 mL 29.3178 mL 58.6356 mL 73.2944 mL
5 mM 0.5864 mL 2.9318 mL 5.8636 mL 11.7271 mL 14.6589 mL
10 mM 0.2932 mL 1.4659 mL 2.9318 mL 5.8636 mL 7.3294 mL
50 mM 0.0586 mL 0.2932 mL 0.5864 mL 1.1727 mL 1.4659 mL
100 mM 0.0293 mL 0.1466 mL 0.2932 mL 0.5864 mL 0.7329 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Methimepip dihydrobromide

N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist.[Pubmed:15771452]

J Med Chem. 2005 Mar 24;48(6):2100-7.

In this study, we continue our efforts toward the development of potent and highly selective histamine H(3) receptor agonists. We introduced various alkyl or aryl alkyl groups on the piperidine nitrogen of the known H(3)/H(4) agonist immepip and its analogues (1-3a). We observed that N-methyl-substituted immepip (methimepip) exhibits high affinity and agonist activity at the human histamine H(3) receptor (pK(i) = 9.0 and pEC(50) = 9.5) with a 2000-fold selectivity at the human H(3) receptor over the human H(4) receptor and more than a 10000-fold selectivity over the human histamine H(1) and H(2) receptors. Methimepip was also very effective as an H(3) receptor agonist at the guinea pig ileum (pD(2) = 8.26). Moreover, in vivo microdialysis (in rat brain) showed that methimepip reduces the basal level of brain histamine to about 25% after a 5 mg/kg intraperitoneal administration.

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