Niazimicin

CAS# 147821-49-6

Niazimicin

Catalog No. BCN7641----Order now to get a substantial discount!

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Quality Control of Niazimicin

Number of papers citing our products

Chemical structure

Niazimicin

3D structure

Chemical Properties of Niazimicin

Cas No. 147821-49-6 SDF Download SDF
PubChem ID 10247749 Appearance Oil
Formula C16H23NO6S M.Wt 357.42
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name O-ethyl N-[[4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphenyl]methyl]carbamothioate
SMILES CCOC(=S)NCC1=CC=C(C=C1)OC2C(C(C(C(O2)C)O)O)O
Standard InChIKey JOSHUAQJVMGTGS-NBUQLFNLSA-N
Standard InChI InChI=1S/C16H23NO6S/c1-3-21-16(24)17-8-10-4-6-11(7-5-10)23-15-14(20)13(19)12(18)9(2)22-15/h4-7,9,12-15,18-20H,3,8H2,1-2H3,(H,17,24)/t9-,12-,13+,14+,15-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Niazimicin

The seeds of Moringa oleifera.

Biological Activity of Niazimicin

Description1. Niazimicin has potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as initiator and TPA as tumor promoter, it is proposed to be a potent chemo-preventive agent. 2. Niazimicin shows antimicrobial activity. 3. Niazimicin has hypotensive and spasmolytic activities. 4. Niazimicin are NF-B and PI3K inhibitors.
TargetsPI3K | NF-kB | AChR | Antifection

Niazimicin Dilution Calculator

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Niazimicin Molarity Calculator

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Preparing Stock Solutions of Niazimicin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7978 mL 13.9891 mL 27.9783 mL 55.9566 mL 69.9457 mL
5 mM 0.5596 mL 2.7978 mL 5.5957 mL 11.1913 mL 13.9891 mL
10 mM 0.2798 mL 1.3989 mL 2.7978 mL 5.5957 mL 6.9946 mL
50 mM 0.056 mL 0.2798 mL 0.5596 mL 1.1191 mL 1.3989 mL
100 mM 0.028 mL 0.1399 mL 0.2798 mL 0.5596 mL 0.6995 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Niazimicin

Synergistic antimicrobial efficacy of mesoporous ZnO loaded with 4-(alpha-L-rhamnosyloxy)-benzyl isothiocyanate isolated from the Moringa oleifera seed.[Pubmed:25742976]

J Gen Appl Microbiol. 2014;60(6):251-5.

The antimicrobial activities of isolated compounds from seed extracts of Moringa oleifera and synergistic antimicrobial efficacy through hybridized complex of organic-inorganic composite materials were studied. The two main components of the Moringa oleifera seed were isolated and determined to be Niazimicin and 4-(alpha-L-rhamnosyloxy)-benzyl isothiocyanate (RBI). The antimicrobial activity of the separated compounds of the Moringa oleifera seed were tested in vitro against 3 bacterial species and 2 fungal species by the paper disc diffusion assay and broth dilution methods. Both compounds showed antimicrobial activity against tested species and RBI was more effective than Niazimicin. The MIC of RBI on S. aureus, E. coli, P. aeruginosa, C. albicans, and A. niger was 0.005%, 0.1%, 0.5%, 0.5%, and 0.5%, respectively, while the MIC of Niazimicin on S. aureus was 0.1%. Next, we investigated the combined antimicrobial action of mesoporous ZnO and RBI by incorporating the compound within the pore of mesoporous ZnO. The MIC of mesoporous ZnO with RBI on S. aureus, E. coli, P. aeruginosa, C. albicans, and A. niger was 0.001%, 0.01%, 0.5%, 0.1%, and 0.1%, respectively. A synergistic effect of RBI with mesoporous ZnO was shown. From these results, the mesoporous ZnO could act as a reservoir for RBI and mesoporous ZnO with RBI could be used for cosmetic preservatives.

Review: an exposition of medicinal preponderance of Moringa oleifera (Lank.).[Pubmed:24577932]

Pak J Pharm Sci. 2014 Mar;27(2):397-403.

Medicinal plants are believed to be a precious natural reservoir as they are assumed to have paranormal effects for the mankind. Moringa oleifera grows throughout most of the tropics and has numerous industrial and medicinal uses. This review acquaints with the consequence of fera (Moringaceae), a fast growing medicinal plant wide spread in tropical regions with height ranging from 5-10m. It has an enormous nutritional worth due to existence of vitamins and proteins. It is subsisted with many constituents. Its oil consists of oleic, tocopherols, stearic, palmitic, behenic and arachidic acid. Flavanoids and phenolics such as gallic acid, chlorogenic acid, ferulic acid, kaempferol, ellagic acid, quercetin and vanillin are present by means of leaf extract, being richest in phenolics and subsequent fruit and seed extract respectively, that are accountable for antioxidant activity of plant. Seeds have been pragmatic with active components as novel O-ethyl-4- (alpha -L-rhamnosyloxy) benzyl carbamate together with seven known compounds, 4 (alpha -L-rhamnosyloxy)-benzyl isothiocyanate, Niazimicin, niazirin, beta-sitosterol, glycerol-1- (9 -octadecanoate), 3 -O- 6 -O-oleoyl- beta -D-glucopyranosyl-b-sitosterol, and beta - sitosterol- 3-X-O -beta -D-glucopyranoside , that have been discerned to inhibit EBV-EA (Epstein- Barr virus-early antigen), that is persuaded by the cancer promoter. M. oleifera leaves, gums, roots, flowers as well as kernels have been unanimously utilized for managing tissue tenderness, cardiovascular and liver maladies, normalize blood glucose and cholesterol. It has also profound antimicrobial, hypoglycemic and anti-tubercular activities.

An antitumor promoter from Moringa oleifera Lam.[Pubmed:10209341]

Mutat Res. 1999 Apr 6;440(2):181-8.

In the course of studies on the isolation of bioactive compounds from Philippine plants, the seeds of Moringa oleifera Lam. were examined and from the ethanol extract were isolated the new O-ethyl-4-(alpha-L-rhamnosyloxy)benzyl carbamate (1) together with seven known compounds, 4(alpha-L-rhamnosyloxy)-benzyl isothiocyanate (2), Niazimicin (3), niazirin (4), beta-sitosterol (5), glycerol-1-(9-octadecanoate) (6), 3-O-(6'-O-oleoyl-beta-D-glucopyranosyl)-beta-sitosterol (7), and beta-sitosterol-3-O-beta-D-glucopyranoside (8). Four of the isolates (2, 3, 7, and 8), which were obtained in relatively good yields, were tested for their potential antitumor promoting activity using an in vitro assay which tested their inhibitory effects on Epstein-Barr virus-early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). All the tested compounds showed inhibitory activity against EBV-EA activation, with compounds 2, 3 and 8 having shown very significant activities. Based on the in vitro results, Niazimicin (3) was further subjected to in vivo test and found to have potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as initiator and TPA as tumor promoter. From these results, Niazimicin (3) is proposed to be a potent chemo-preventive agent in chemical carcinogenesis.

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