PF 998425

Non-steroidal androgen receptor antagonist CAS# 1076225-27-8

PF 998425

Catalog No. BCC7811----Order now to get a substantial discount!

Product Name & Size Price Stock
PF 998425: 5mg $115 In Stock
PF 998425: 10mg Please Inquire In Stock
PF 998425: 20mg Please Inquire Please Inquire
PF 998425: 50mg Please Inquire Please Inquire
PF 998425: 100mg Please Inquire Please Inquire
PF 998425: 200mg Please Inquire Please Inquire
PF 998425: 500mg Please Inquire Please Inquire
PF 998425: 1000mg Please Inquire Please Inquire
Related Products
  • S 32826

    Catalog No.:BCC7678
    CAS No.:1103672-43-0
  • HA 130

    Catalog No.:BCC7884
    CAS No.:1229652-21-4

Quality Control of PF 998425

Number of papers citing our products

Chemical structure

PF 998425

3D structure

Chemical Properties of PF 998425

Cas No. 1076225-27-8 SDF Download SDF
PubChem ID 25093231 Appearance Powder
Formula C14H14F3NO M.Wt 269.26
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
Chemical Name 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)benzonitrile
SMILES C1CCC(C(C1)C2=CC(=C(C=C2)C#N)C(F)(F)F)O
Standard InChIKey MENRRRXHFQYXDW-DGCLKSJQSA-N
Standard InChI InChI=1S/C14H14F3NO/c15-14(16,17)12-7-9(5-6-10(12)8-18)11-3-1-2-4-13(11)19/h5-7,11,13,19H,1-4H2/t11-,13-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of PF 998425

DescriptionSelective non-steroidal androgen receptor (AR) antagonist (IC50 values are 26 nM and 90 nM in AR binding assays and cellular assays respectively). Displays low affinity for progesterone receptor (IC50 > 10 μM). Active in vivo.

PF 998425 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

PF 998425 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of PF 998425

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7139 mL 18.5694 mL 37.1388 mL 74.2776 mL 92.8471 mL
5 mM 0.7428 mL 3.7139 mL 7.4278 mL 14.8555 mL 18.5694 mL
10 mM 0.3714 mL 1.8569 mL 3.7139 mL 7.4278 mL 9.2847 mL
50 mM 0.0743 mL 0.3714 mL 0.7428 mL 1.4856 mL 1.8569 mL
100 mM 0.0371 mL 0.1857 mL 0.3714 mL 0.7428 mL 0.9285 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on PF 998425

Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.[Pubmed:18921992]

J Med Chem. 2008 Nov 13;51(21):7010-4.

4-((1 R,2 R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile [PF-0998425, (-)- 6a] is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. It is potent, selective, and active in vivo. The compound is rapidly metabolized systemically, thereby reducing the risk of unwanted systemic side effects due to its primary pharmacology. (-)- 6a was tested negative in the 3T3 NRU assay, validating our rationale that reduction of conjugation might reduce potential phototoxicity.

Keywords:

PF 998425,1076225-27-8,Natural Products,Androgen Receptor, buy PF 998425 , PF 998425 supplier , purchase PF 998425 , PF 998425 cost , PF 998425 manufacturer , order PF 998425 , high purity PF 998425

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: