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Pefloxacin Mesylate Dihydrate

CAS# 149676-40-4

Pefloxacin Mesylate Dihydrate

Catalog No. BCC5089----Order now to get a substantial discount!

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Pefloxacin Mesylate Dihydrate: 5mg $6 In Stock
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Chemical structure

Pefloxacin Mesylate Dihydrate

3D structure

Chemical Properties of Pefloxacin Mesylate Dihydrate

Cas No. 149676-40-4 SDF Download SDF
PubChem ID 6917670 Appearance Powder
Formula C18H28FN3O8S M.Wt 465.49
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Pefloxacinium mesylate dihydrate
Solubility Soluble in DMSO > 10 mM
Chemical Name 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;methanesulfonic acid;dihydrate
SMILES CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O.CS(=O)(=O)O.O.O
Standard InChIKey LEULAXMUNMRLPW-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Pefloxacin Mesylate Dihydrate

DescriptionPefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) Target: DNA gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections. Pefloxacin is commonly referred to as afluoroquinolone (or quinolone) drug and is a member of the fluoroquinolone class of antibacterials. It is an analog of norfloxacin. It is a synthetic fluoroquinolone, belonging to the 3rd generation of quinolones. Pefloxacin is extensively prescribed in France. Pefloxacin has not been approved for use in the United States. The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

References:
[1]. Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. [2]. Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.

Pefloxacin Mesylate Dihydrate Dilution Calculator

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Pefloxacin Mesylate Dihydrate Molarity Calculator

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Preparing Stock Solutions of Pefloxacin Mesylate Dihydrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1483 mL 10.7414 mL 21.4827 mL 42.9655 mL 53.7068 mL
5 mM 0.4297 mL 2.1483 mL 4.2965 mL 8.5931 mL 10.7414 mL
10 mM 0.2148 mL 1.0741 mL 2.1483 mL 4.2965 mL 5.3707 mL
50 mM 0.043 mL 0.2148 mL 0.4297 mL 0.8593 mL 1.0741 mL
100 mM 0.0215 mL 0.1074 mL 0.2148 mL 0.4297 mL 0.5371 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Pefloxacin Mesylate Dihydrate

Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse)

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Description

Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) Target: DNA gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections.

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