Phebalosin

CAS# 6545-99-9

Phebalosin

Catalog No. BCN4198----Order now to get a substantial discount!

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Quality Control of Phebalosin

Number of papers citing our products

Chemical structure

Phebalosin

3D structure

Chemical Properties of Phebalosin

Cas No. 6545-99-9 SDF Download SDF
PubChem ID 188300 Appearance Cryst.
Formula C15H14O4 M.Wt 258.3
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 7-methoxy-8-[(2R,3R)-3-prop-1-en-2-yloxiran-2-yl]chromen-2-one
SMILES CC(=C)C1C(O1)C2=C(C=CC3=C2OC(=O)C=C3)OC
Standard InChIKey YTDNHMHONBWCBV-UKRRQHHQSA-N
Standard InChI InChI=1S/C15H14O4/c1-8(2)13-15(19-13)12-10(17-3)6-4-9-5-7-11(16)18-14(9)12/h4-7,13,15H,1H2,2-3H3/t13-,15-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Phebalosin

The herbs of Murraya exotica L.

Biological Activity of Phebalosin

Description1. Phebalosin displays 50% effective concentrations (EC(50)) of 14.1 microg/mL against axenic amastigote forms of Leishmania panamensis. 2. Phebalosin displays cytotoxicity (IC(50)) at concentrations of 20.7 microg/mL on human promonocytic U-937 cells.
TargetsAntifection

Phebalosin Dilution Calculator

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Phebalosin Molarity Calculator

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Preparing Stock Solutions of Phebalosin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8715 mL 19.3573 mL 38.7147 mL 77.4293 mL 96.7867 mL
5 mM 0.7743 mL 3.8715 mL 7.7429 mL 15.4859 mL 19.3573 mL
10 mM 0.3871 mL 1.9357 mL 3.8715 mL 7.7429 mL 9.6787 mL
50 mM 0.0774 mL 0.3871 mL 0.7743 mL 1.5486 mL 1.9357 mL
100 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.7743 mL 0.9679 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Phebalosin

Coumarins from Galipea panamensis and Their Activity against Leishmania panamensis.[Pubmed:20423106]

J Nat Prod. 2010 May 28;73(5):1012-4.

Two new coumarin compounds (1 and 2), Phebalosin (3), its derived artifact murralongin (4), and murrangatin acetonide (5) were isolated from the leaves of Galipea panamensis. The structures of 1 and 2 were assigned as 7-{[(2R*)-3,3-dimethyloxiran-2-yl]methoxy}-8-[(2R*,3R*)-3-isopropenyloxiran-2-yl] -2H-chromen-2-one and 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, respectively, on the basis of their spectroscopic data (primarily NMR and MS). Compounds 1-3 were tested against axenic amastigote forms of Leishmania panamensis and displayed 50% effective concentrations (EC(50)) of 9.9, 10.5, and 14.1 microg/mL, respectively. These three compounds also displayed cytotoxicity (IC(50)) at concentrations of 9.7, 33.0, and 20.7 microg/mL, respectively, on human promonocytic U-937 cells.

[Study on the chemical constituents from ethyl acetate extract of Micromelum falcatum].[Pubmed:24218965]

Zhong Yao Cai. 2013 May;36(5):744-6.

OBJECTIVE: To study the chemical constituents from ethyl acetate extract of Micromelum falcatum. METHODS: The constituents were separated and purified by silica gel, Sephadex LH-20 and HPLC. Their structures were elucidated by spectral analysis (NMR, MS). RESULTS: Ten compounds were isolated and identified as micropubescin (1), Phebalosin (2), scopoletin (3), citrubuntin (4), thamnosmonin (5), hopeyhopin (6), arnottinin (7), casegravol (8), 2-methoxy-5-hydroxy cinnamate (9), threo-syringoylglycerol (10). CONCLUSION: Compounds 1 - 10 are obtained from this plant for the first time.

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