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Polygalaxanthone XI

CAS# 857859-82-6

Polygalaxanthone XI

Catalog No. BCN7366----Order now to get a substantial discount!

Product Name & Size Price Stock
Polygalaxanthone XI: 5mg $35 In Stock
Polygalaxanthone XI: 10mg Please Inquire In Stock
Polygalaxanthone XI: 20mg Please Inquire Please Inquire
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Quality Control of Polygalaxanthone XI

Number of papers citing our products

Chemical structure

Polygalaxanthone XI

3D structure

Chemical Properties of Polygalaxanthone XI

Cas No. 857859-82-6 SDF Download SDF
PubChem ID 101740054 Appearance Powder
Formula C25H28O15 M.Wt 568.48
Type of Compound Xanthones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-1,3,6-trihydroxy-7-methoxyxanthen-9-one
SMILES COC1=C(C=C2C(=C1)C(=O)C3=C(C(=C(C=C3O2)O)C4C(C(C(C(O4)CO)O)O)OC5C(C(CO5)(CO)O)O)O)O
Standard InChIKey GTRLQDJSEMBQNI-LYHRZCPZSA-N
Standard InChI InChI=1S/C25H28O15/c1-36-12-2-8-11(3-9(12)28)38-13-4-10(29)15(19(32)16(13)17(8)30)21-22(20(33)18(31)14(5-26)39-21)40-24-23(34)25(35,6-27)7-37-24/h2-4,14,18,20-24,26-29,31-35H,5-7H2,1H3/t14-,18-,20+,21+,22-,23+,24+,25-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Polygalaxanthone XI

The roots of Polygala tenuifolia.

Biological Activity of Polygalaxanthone XI

DescriptionPolygalaxanthone XI is a natural product from Polygala tenuifolia.

Protocol of Polygalaxanthone XI

Structure Identification
J Sep Sci. 2007 Nov;30(16):2583-9.

Simultaneous determination of phenols in Radix Polygalae by high performance liquid chromatography: quality assurance of herbs from different regions and seasons.[Pubmed: 17722189 ]

Radix Polygalae, roots of Polygala tenuifolia or of Polygala sibirica, is a Chinese herbal medicine commonly used to prevent dementia. Reliable chemical markers for quality assurance of this herb are missing.
METHODS AND RESULTS:
Here, a high performance liquid chromatography method coupled with diode array detection was developed to simultaneously determine nine different phenols in Radix Polygalae, including sibiricose A(5), sibiricose A(6), glomeratose A, tenuifoliside A, glomeratose D, 3',6-di-O-sinapoyl sucrose ester, mangiferin, polygalaxanthone III, and Polygalaxanthone XI. By using two different detection wavelengths in the HPLC analysis, the developed method was able to determine the phenols with excellent resolution, precision, and recovery.
CONCLUSIONS:
This established method was therefore applied to determine the amounts of phenols in thirty-two samples from different cultivation regions and harvest seasons in China, and significant variations were revealed. The amounts of phenols in the roots of P. tenuifolia collected in Shanxi and Shannxi Provinces were markedly higher than in roots collected from other Provinces. Moreover, the samples harvested in the spring contained higher contents of phenols than those collected in other seasons.

Polygalaxanthone XI Dilution Calculator

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Polygalaxanthone XI Molarity Calculator

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Preparing Stock Solutions of Polygalaxanthone XI

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7591 mL 8.7954 mL 17.5908 mL 35.1815 mL 43.9769 mL
5 mM 0.3518 mL 1.7591 mL 3.5182 mL 7.0363 mL 8.7954 mL
10 mM 0.1759 mL 0.8795 mL 1.7591 mL 3.5182 mL 4.3977 mL
50 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.7036 mL 0.8795 mL
100 mM 0.0176 mL 0.088 mL 0.1759 mL 0.3518 mL 0.4398 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Polygalaxanthone XI

Simultaneous determination of phenols in Radix Polygalae by high performance liquid chromatography: quality assurance of herbs from different regions and seasons.[Pubmed:17722189]

J Sep Sci. 2007 Nov;30(16):2583-9.

Radix Polygalae, roots of Polygala tenuifolia or of Polygala sibirica, is a Chinese herbal medicine commonly used to prevent dementia. Reliable chemical markers for quality assurance of this herb are missing. Here, a high performance liquid chromatography method coupled with diode array detection was developed to simultaneously determine nine different phenols in Radix Polygalae, including sibiricose A(5), sibiricose A(6), glomeratose A, tenuifoliside A, glomeratose D, 3',6-di-O-sinapoyl sucrose ester, mangiferin, polygalaxanthone III, and Polygalaxanthone XI. By using two different detection wavelengths in the HPLC analysis, the developed method was able to determine the phenols with excellent resolution, precision, and recovery. This established method was therefore applied to determine the amounts of phenols in thirty-two samples from different cultivation regions and harvest seasons in China, and significant variations were revealed. The amounts of phenols in the roots of P. tenuifolia collected in Shanxi and Shannxi Provinces were markedly higher than in roots collected from other Provinces. Moreover, the samples harvested in the spring contained higher contents of phenols than those collected in other seasons.

Description

Polygalaxanthone XI, a xanthone glycoside isolated from the cortexes of Polygala tenuifolia, can be used in the study of expectorant, sedative, and tranquilizing agent.

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