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Przewalskinic acid A

CAS# 136112-75-9

Przewalskinic acid A

Catalog No. BCN2925----Order now to get a substantial discount!

Product Name & Size Price Stock
Przewalskinic acid A: 5mg $265 In Stock
Przewalskinic acid A: 10mg Please Inquire In Stock
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Quality Control of Przewalskinic acid A

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Chemical structure

Przewalskinic acid A

3D structure

Chemical Properties of Przewalskinic acid A

Cas No. 136112-75-9 SDF Download SDF
PubChem ID 9975641 Appearance Powder
Formula C18H14O8 M.Wt 358.3
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,3R)-4-[(E)-2-carboxyethenyl]-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid
SMILES C1=CC(=C(C=C1C2C(C3=C(C=CC(=C3O2)O)C=CC(=O)O)C(=O)O)O)O
Standard InChIKey GJHXGOBGPWPCCK-DBLORFJXSA-N
Standard InChI InChI=1S/C18H14O8/c19-10-4-2-9(7-12(10)21)16-15(18(24)25)14-8(3-6-13(22)23)1-5-11(20)17(14)26-16/h1-7,15-16,19-21H,(H,22,23)(H,24,25)/b6-3+/t15-,16+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Przewalskinic acid A

The roots of Salvia miltiorrhiza Bge.

Biological Activity of Przewalskinic acid A

DescriptionPrzewalskinic acid A is a rare, water-soluble, and highly biologically active ingredient found, thus far, only in the Salvia przewalskii Maxim herb.

Protocol of Przewalskinic acid A

Structure Identification
J Ind Microbiol Biotechnol. 2014 May;41(5):887-92.

Preparation of przewalskinic acid A from salvianolic acid B using a crude enzyme from an Aspergillus oryzae strain.[Pubmed: 24615145 ]

Przewalskinic acid A is a rare, water-soluble, and highly biologically active ingredient found, thus far, only in the Salvia przewalskii Maxim herb; however, the content in S. przewalskii herb is very low.
METHODS AND RESULTS:
In order to obtain useful quantities of Przewalskinic acid A, the biotransformatin of salvianolic acid B from Salvia miltiorrhiza root (danshen in Chinese) into Przewalskinic acid A was studied using a crude enzyme produced from Aspergillus oryzae D30s strain. The crude enzyme from the A. oryzae strain hydrolyzed salvianolic acid B into Przewalskinic acid A and danshensu. The preparation afforded 31.3 g Przewalskinic acid A (91.0 % purity) and 13.1 g danshensu (95 % purity) from 75 g salvianolic acid B. The preparation of Przewalskinic acid A was therefore very successful with a yield of over 86 %, but the yield of danshensu was only 33 %.
CONCLUSIONS:
The product Przewalskinic acid A was identified using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and NMR.

Przewalskinic acid A Dilution Calculator

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Przewalskinic acid A Molarity Calculator

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Preparing Stock Solutions of Przewalskinic acid A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.791 mL 13.9548 mL 27.9096 mL 55.8191 mL 69.7739 mL
5 mM 0.5582 mL 2.791 mL 5.5819 mL 11.1638 mL 13.9548 mL
10 mM 0.2791 mL 1.3955 mL 2.791 mL 5.5819 mL 6.9774 mL
50 mM 0.0558 mL 0.2791 mL 0.5582 mL 1.1164 mL 1.3955 mL
100 mM 0.0279 mL 0.1395 mL 0.2791 mL 0.5582 mL 0.6977 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Przewalskinic acid A

Preparation of przewalskinic acid A from salvianolic acid B using a crude enzyme from an Aspergillus oryzae strain.[Pubmed:24615145]

J Ind Microbiol Biotechnol. 2014 May;41(5):887-92.

Przewalskinic acid A is a rare, water-soluble, and highly biologically active ingredient found, thus far, only in the Salvia przewalskii Maxim herb; however, the content in S. przewalskii herb is very low. In order to obtain useful quantities of Przewalskinic acid A, the biotransformatin of salvianolic acid B from Salvia miltiorrhiza root (danshen in Chinese) into Przewalskinic acid A was studied using a crude enzyme produced from Aspergillus oryzae D30s strain. The crude enzyme from the A. oryzae strain hydrolyzed salvianolic acid B into Przewalskinic acid A and danshensu. The preparation afforded 31.3 g Przewalskinic acid A (91.0 % purity) and 13.1 g danshensu (95 % purity) from 75 g salvianolic acid B. The preparation of Przewalskinic acid A was therefore very successful with a yield of over 86 %, but the yield of danshensu was only 33 %. The product Przewalskinic acid A was identified using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and NMR.

Description

Przewalskinic acid A is a rare, water-soluble phenolic acid thus far only found in the Salvia przewalskii Maxim herb. Phenolic acids show potent antioxidant activities and potential effects in protecting against brain and heart damage caused by ischemia reperfusion.

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