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Quercetin-3-O-glucose-6'-acetate

CAS# 54542-51-7

Quercetin-3-O-glucose-6'-acetate

Catalog No. BCN6545----Order now to get a substantial discount!

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Quality Control of Quercetin-3-O-glucose-6'-acetate

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Chemical structure

Quercetin-3-O-glucose-6'-acetate

3D structure

Chemical Properties of Quercetin-3-O-glucose-6'-acetate

Cas No. 54542-51-7 SDF Download SDF
PubChem ID 10006384 Appearance Yellow powder
Formula C23H22O13 M.Wt 506.41
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(2R,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl acetate
SMILES CC(=O)OCC1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O
Standard InChIKey IGLUNMMNDNWZOA-LNNZMUSMSA-N
Standard InChI InChI=1S/C23H22O13/c1-8(24)33-7-15-17(29)19(31)20(32)23(35-15)36-22-18(30)16-13(28)5-10(25)6-14(16)34-21(22)9-2-3-11(26)12(27)4-9/h2-6,15,17,19-20,23,25-29,31-32H,7H2,1H3/t15-,17-,19+,20-,23+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Quercetin-3-O-glucose-6'-acetate

The leaves of Morus alba L.

Biological Activity of Quercetin-3-O-glucose-6'-acetate

Description1. Quercetin-3-O-glucose-6''-acetate has antioxidant capacity. 2. Quercetin-3-O-glucose-6''-acetate is a NADPH oxidase inhibitor.
TargetsNADPH-oxidase | ROS

Quercetin-3-O-glucose-6'-acetate Dilution Calculator

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Quercetin-3-O-glucose-6'-acetate Molarity Calculator

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Preparing Stock Solutions of Quercetin-3-O-glucose-6'-acetate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9747 mL 9.8734 mL 19.7468 mL 39.4937 mL 49.3671 mL
5 mM 0.3949 mL 1.9747 mL 3.9494 mL 7.8987 mL 9.8734 mL
10 mM 0.1975 mL 0.9873 mL 1.9747 mL 3.9494 mL 4.9367 mL
50 mM 0.0395 mL 0.1975 mL 0.3949 mL 0.7899 mL 0.9873 mL
100 mM 0.0197 mL 0.0987 mL 0.1975 mL 0.3949 mL 0.4937 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Quercetin-3-O-glucose-6'-acetate

A Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants.[Pubmed:21312054]

Mol Cell Biochem. 2011 Jun;352(1-2):91-8.

NADPH oxidase is the major source of non-mitochondrial cellular reactive oxygen species (ROS), and also is reported to be a major cause of various diseases including atherosclerosis and hypertension. In order to screen a new curative reagent that can suppress NADPH oxidase activity, we developed a Drosophila melanogaster fly that would overexpress human Dual oxidase 2 (hDuox2), a member of the NADPH oxidase family, as a screening model. These flies (GMR-GAL4/UAS-hDuox2) had a high generation of ROS in the posterior region of the eye discs along with an easily recognizable rough-eye phenotype, which is an ideal and convenient marker for further screening steps. Moreover, the hDuox2-induced rough-eye phenotype can be rescued by feeding with a culture medium containing mulberry leaves (MLs), which reportedly have an antimetabolic effect. Some commercially available antioxidants such as quercetin-3-O-D-glucoside or quercetin-3-O-glucose-6''-acetate, or the naringin contained in MLs and other herbs, also have shown a similar suppressing effect on the rough-eye phenotype. Our results suggest that flavonoid glycoside is absorbed from the intestine and functions in the body of D. melanogaster as it does in mammalian models such as rats. Thus, the GMR-GAL4/UAS-hDuox2 fly line is a promising model for the screening of novel drugs such as NADPH oxidase inhibitors and/or antioxidants.

Flavonol content in the water extract of the mulberry (Morus alba L.) leaf and their antioxidant capacities.[Pubmed:22417484]

J Food Sci. 2011 Aug;76(6):C869-73.

UNLABELLED: The biological activities of the mulberry (Morus alba L.) leaf have been attributed to its flavonoid content. The water extract of the mulberry leaf (WEML) was prepared by autoclaving at 121 degrees C for 15 min, and the flavonol content of the WEML was determined by HPLC The WEML contained 4 flavonols in the following order: quercetin-3-beta-D-glucose (QT-G) > quercetin-3-O-glucose-6''-acetate (QT-GA) > rutin (RT) > quercetin (QT). In the oxygen radical absorbance capacity (ORAC) assay, QT had the highest peroxyl radical-scavenging capacity and a similar hydroxyl radical-scavenging capacity as its glycosides (QT-G, QT-GA, and RT). QT exhibited a stronger cellular antioxidant capacity (CAC) against 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH)- and Cu(2)(+)-induced oxidative stress in HepG2 cells compared to its glycosides, indicating that the intracellular antioxidant capacity of QT and its glycosides may depend upon both the permeability across the cell membrane and the peroxyl or hydroxyl radical-scavenging capacity. PRACTICAL APPLICATION: The information presented might be used for developing mulberry leaf-based functional foods.

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