Rink Amide Linker

CAS# 145069-56-3

Rink Amide Linker

Catalog No. BCC2833----Order now to get a substantial discount!

Product Name & Size Price Stock
Rink Amide Linker: 5mg $6 In Stock
Rink Amide Linker: 10mg Please Inquire In Stock
Rink Amide Linker: 20mg Please Inquire Please Inquire
Rink Amide Linker: 50mg Please Inquire Please Inquire
Rink Amide Linker: 100mg Please Inquire Please Inquire
Rink Amide Linker: 200mg Please Inquire Please Inquire
Rink Amide Linker: 500mg Please Inquire Please Inquire
Rink Amide Linker: 1000mg Please Inquire Please Inquire
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Quality Control of Rink Amide Linker

Number of papers citing our products

Chemical structure

Rink Amide Linker

3D structure

Chemical Properties of Rink Amide Linker

Cas No. 145069-56-3 SDF Download SDF
PubChem ID 2761459 Appearance Powder
Formula C32H29NO7 M.Wt 539.6
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-[4-[(2,4-dimethoxyphenyl)-(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenoxy]acetic acid
SMILES COC1=CC(=C(C=C1)C(C2=CC=C(C=C2)OCC(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)OC
Standard InChIKey UPMGJEMWPQOACJ-UHFFFAOYSA-N
Standard InChI InChI=1S/C32H29NO7/c1-37-22-15-16-27(29(17-22)38-2)31(20-11-13-21(14-12-20)39-19-30(34)35)33-32(36)40-18-28-25-9-5-3-7-23(25)24-8-4-6-10-26(24)28/h3-17,28,31H,18-19H2,1-2H3,(H,33,36)(H,34,35)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Rink Amide Linker Dilution Calculator

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Rink Amide Linker Molarity Calculator

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Preparing Stock Solutions of Rink Amide Linker

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8532 mL 9.2661 mL 18.5322 mL 37.0645 mL 46.3306 mL
5 mM 0.3706 mL 1.8532 mL 3.7064 mL 7.4129 mL 9.2661 mL
10 mM 0.1853 mL 0.9266 mL 1.8532 mL 3.7064 mL 4.6331 mL
50 mM 0.0371 mL 0.1853 mL 0.3706 mL 0.7413 mL 0.9266 mL
100 mM 0.0185 mL 0.0927 mL 0.1853 mL 0.3706 mL 0.4633 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Rink Amide Linker

C-terminal N-alkylated peptide amides resulting from the linker decomposition of the Rink amide resin: a new cleavage mixture prevents their formation.[Pubmed:16103992]

J Pept Sci. 2006 Mar;12(3):227-32.

Decomposition of the resin linkers during TFA cleavage of the peptides in the Fmoc strategy leads to alkylation of sensitive amino acids. The C-terminal amide alkylation, reported for the first time, is shown to be a major problem in peptide amides synthesized on the Rink amide resin. This side reaction occurs as a result of the Rink Amide Linker decomposition under TFA treatment of the peptide resin. The use of 1,3-dimethoxybenzene in a cleavage cocktail prevents almost quantitatively formation of C-terminal N-alkylated peptide amides. Oxidized by-product in the tested Cys- and Met-containing peptides were not observed, even if thiols were not used in the cleavage mixture.

Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein.[Pubmed:25196573]

Chem Commun (Camb). 2014 Oct 25;50(83):12534-7.

Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.

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