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Risperidone hydrochloride

CAS# 666179-74-4

Risperidone hydrochloride

Catalog No. BCC4205----Order now to get a substantial discount!

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Chemical structure

Risperidone hydrochloride

3D structure

Chemical Properties of Risperidone hydrochloride

Cas No. 666179-74-4 SDF Download SDF
PubChem ID 9889802 Appearance Powder
Formula C23H28ClFN4O2 M.Wt 446.95
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO
Chemical Name 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one;hydrochloride
SMILES CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F.Cl
Standard InChIKey OCBZQKQWVUTYDN-UHFFFAOYSA-N
Standard InChI InChI=1S/C23H27FN4O2.ClH/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22;/h5-6,14,16H,2-4,7-13H2,1H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Risperidone hydrochloride Dilution Calculator

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Risperidone hydrochloride Molarity Calculator

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Preparing Stock Solutions of Risperidone hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2374 mL 11.1869 mL 22.3739 mL 44.7477 mL 55.9347 mL
5 mM 0.4475 mL 2.2374 mL 4.4748 mL 8.9495 mL 11.1869 mL
10 mM 0.2237 mL 1.1187 mL 2.2374 mL 4.4748 mL 5.5935 mL
50 mM 0.0447 mL 0.2237 mL 0.4475 mL 0.895 mL 1.1187 mL
100 mM 0.0224 mL 0.1119 mL 0.2237 mL 0.4475 mL 0.5593 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Risperidone hydrochloride

Risperidone Hcl(R 64 766 Hcl) is a serotonin 5-HT2 receptor blocker(Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist(Ki= 1.4 nM).

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References on Risperidone hydrochloride

Extractive colorimetric method for the determination of dothiepin hydrochloride and risperidone in pure and in dosage forms.[Pubmed:18670108]

Chem Pharm Bull (Tokyo). 2008 Aug;56(8):1092-6.

Three rapid, simple, reproducible and sensitive extractive colorimetric methods (A--C) for assaying dothiepin hydrochloride (I) and risperidone (II) in bulk sample and in dosage forms were investigated. Methods A and B are based on the formation of an ion pair complexes with methyl orange (A) and orange G (B), whereas method C depends on ternary complex formation between cobalt thiocyanate and the studied drug I or II. The optimum reaction conditions were investigated and it was observed the calibration curves resulting from the measurements of absorbance concentration relations of the extracted complexes were linear over the concentration range 0.1--12 microg ml(-1) for method A, 0.5--11 mug ml(-1) for method B, and 3.2--80 microg ml(-1) for method C with a relative standard deviation (RSD) of 1.17 and 1.28 for drug I and II, respectively. The molar absorptivity, Sandell sensitivity, Ringbom optimum concentration ranges, and detection and quantification limits for all complexes were calculated and evaluated at maximum wavelengths of 423, 498, and 625 nm, using methods A, B, and C, respectively. The interference from excipients commonly present in dosage forms and common degradation products was studied. The proposed methods are highly specific for the determination of drugs I and II, in their dosage forms applying the standard additions technique without any interference from common excipients. The proposed methods have been compared statistically to the reference methods and found to be simple, accurate (t-test) and reproducible (F-value).

New-onset diabetic ketoacidosis induced by the addition of perospirone hydrochloride in a patient treated with risperidone.[Pubmed:17301517]

Intern Med. 2007;46(4):199-200. Epub 2007 Feb 15.

A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan. The new drug had been added to the long-standing treatment with risperidone. Diagnosed with diabetic ketoacidosis, he was given insulin and saline with discontinuation of all antipsychotics. Ultimately, diabetes was controlled by dietary therapy alone despite reintroduction of risperidone. The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.

Description

Risperidone hydrochloride (R 64 766 hydrochloride) 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

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