Scutebata C

CAS# 1207181-59-6

Scutebata C

Catalog No. BCN6098----Order now to get a substantial discount!

Product Name & Size Price Stock
Scutebata C: 5mg $1098 In Stock
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Quality Control of Scutebata C

Number of papers citing our products

Chemical structure

Scutebata C

3D structure

Chemical Properties of Scutebata C

Cas No. 1207181-59-6 SDF Download SDF
PubChem ID 46183386 Appearance Powder
Formula C28H35NO9 M.Wt 529.6
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1R,2S,3R,4S,4aS,8aR)-4-[(1S)-1-acetyloxy-2-(4-hydroxy-5-oxo-2H-furan-3-yl)ethyl]-2,3-dihydroxy-3,4,8,8a-tetramethyl-2,4a,5,6-tetrahydro-1H-naphthalen-1-yl] pyridine-3-carboxylate
SMILES CC1=CCCC2C1(C(C(C(C2(C)C(CC3=C(C(=O)OC3)O)OC(=O)C)(C)O)O)OC(=O)C4=CN=CC=C4)C
Standard InChIKey ZZDJHMJHKZYAFI-MDLIPRPFSA-N
Standard InChI InChI=1S/C28H35NO9/c1-15-8-6-10-19-26(15,3)23(38-24(33)17-9-7-11-29-13-17)22(32)28(5,35)27(19,4)20(37-16(2)30)12-18-14-36-25(34)21(18)31/h7-9,11,13,19-20,22-23,31-32,35H,6,10,12,14H2,1-5H3/t19-,20-,22-,23-,26-,27-,28-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Scutebata C

The herbs of Scutellaria barbata D.Don

Biological Activity of Scutebata C

DescriptionScutebata B possesses a rare alpha-hydroxy group in its alpha,beta-unsaturated lactone rings.
In vitro

Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.[Reference: WebLink]

Journal of Natural Products, 2010, 73(2):233-236.


METHODS AND RESULTS:
Seven new neoclerodane diterpenoids, scutebata A, scutebata B, Scutebata C, scutebata D, scutebata E, scutebata F, scutebata G (1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1.
CONCLUSIONS:
Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.

Scutebata C Dilution Calculator

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Scutebata C Molarity Calculator

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Preparing Stock Solutions of Scutebata C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8882 mL 9.4411 mL 18.8822 mL 37.7644 mL 47.2054 mL
5 mM 0.3776 mL 1.8882 mL 3.7764 mL 7.5529 mL 9.4411 mL
10 mM 0.1888 mL 0.9441 mL 1.8882 mL 3.7764 mL 4.7205 mL
50 mM 0.0378 mL 0.1888 mL 0.3776 mL 0.7553 mL 0.9441 mL
100 mM 0.0189 mL 0.0944 mL 0.1888 mL 0.3776 mL 0.4721 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Scutebata C

Neoclerodane diterpenoids from Scutellaria barbata with cytotoxic activities.[Pubmed:30449170]

Nat Prod Res. 2018 Nov 19:1-7.

Two new neoclerodane diterpenoids, barbatin F (1), barbatin G (2) together with four known compounds, scutebata A (3), scutebata B (4), Scutebata C (5) and scutebata P (6) were isolated from the whole plant of Scutellaria barbata D.Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines LoVo, SMMC-7721, HCT-116, and MCF-7 were evaluated, compound 1 and 2 showed weak cytotoxic activities against HCT-116 colon cancer cell lines with IC50 value of 44.3, 32.3 muM, respectively, while compound 3 and 4 exhibited moderate cytotoxic activities against four tested human cancer cell lines with IC50 values of 5.3128.5 muM.

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