Senkyunolide H

CAS# 94596-27-7

Senkyunolide H

Catalog No. BCN6352----Order now to get a substantial discount!

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Senkyunolide H: 5mg $213 In Stock
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Chemical structure

Senkyunolide H

3D structure

Chemical Properties of Senkyunolide H

Cas No. 94596-27-7 SDF Download SDF
PubChem ID 5321251 Appearance Oil
Formula C12H16O4 M.Wt 224.3
Type of Compound Miscellaneous Storage Desiccate at -20°C
Synonyms AC1NT0CA
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3Z,6S,7R)-3-butylidene-6,7-dihydroxy-4,5,6,7-tetrahydro-2-benzofuran-1-one
SMILES CCCC=C1C2=C(C(C(CC2)O)O)C(=O)O1
Standard InChIKey DQNGMIQSXNGHOA-RCBCECLLSA-N
Standard InChI InChI=1S/C12H16O4/c1-2-3-4-9-7-5-6-8(13)11(14)10(7)12(15)16-9/h4,8,11,13-14H,2-3,5-6H2,1H3/b9-4-/t8-,11-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Senkyunolide H

The roots of Ligusticum chuanxiong hort

Biological Activity of Senkyunolide H

Description1. Senkyunolide H, senkyunolide I and ferulic acid can reduce the metamorphose damage of the RBC caused by ConA, the aggregation of the RBC also could be alleviated by them. 2. Senkyunolide H in cnidium rhizome may be a prototype for an anti-atherosclerotic drug.

Senkyunolide H Dilution Calculator

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Senkyunolide H Molarity Calculator

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Preparing Stock Solutions of Senkyunolide H

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4583 mL 22.2916 mL 44.5831 mL 89.1663 mL 111.4579 mL
5 mM 0.8917 mL 4.4583 mL 8.9166 mL 17.8333 mL 22.2916 mL
10 mM 0.4458 mL 2.2292 mL 4.4583 mL 8.9166 mL 11.1458 mL
50 mM 0.0892 mL 0.4458 mL 0.8917 mL 1.7833 mL 2.2292 mL
100 mM 0.0446 mL 0.2229 mL 0.4458 mL 0.8917 mL 1.1146 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Senkyunolide H

Simultaneous determination of senkyunolide I and senkyunolide H in rat plasma by LC-MS: application to a comparative pharmacokinetic study in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract.[Pubmed:25620053]

Biomed Chromatogr. 2015 Sep;29(9):1297-303.

A selective liquid chromatographic-mass spectrometric method has been developed and validated for simultaneous determination of senkyunolide I (SEI) and Senkyunolide H (SEH) from Chuanxiong Rhizoma in rat plasma. Plasma samples were extracted by liquid-liquid extraction with ethyl acetate and separated on a Kromasil C18 column (250 x 4.6 mm, 5 microm), with methanol-water (55:45, v/v) as mobile phase. The linear range was 0.05-25 microg/mL for SEI and 0.01-5.0 microg/mL for SEH, with lower limits of quantitation of 0.05 and 0.01 microg/mL, respectively. Intra- and inter-day precision were within 10.0 and 9.8%, and the accuracies (relative errors) were <9.6 and 5.9%, with the mean extraction recoveries 81.0-86.6 and 80.5-85.0% for the two anayltes, respectively. The validated method was successfully applied to a comparative pharmacokinetic study of SEI and SEH in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract. The results indicated that there were obvious differences between normal and migrainous rats in the pharmacokinetic behavior after oral administration of Chuanxiong Rhizoma extract. The absorption of SEI and SEH were significantly increased in migrainous rats compared with normal rats.

[Preparation of ferulic acid, senkyunolide I and senkyunolide H from Ligusticum chuanxiong by preparative HPLC].[Pubmed:24066590]

Zhongguo Zhong Yao Za Zhi. 2013 Jun;38(12):1947-50.

Preparative HPLC was used to prepare ferulic acid, senkyunolide I and Senkyunolide H from Ligusticum chuanxiong. The separation was conducted on a Shim-Pack Prep-ODS (20.0 mm x 250 mm, 5 microm) column with the mobile phase of methanol-0.2% glacial acetic acid (50:50)at the flow rate of 5 mL x min(-1). The detection wavelength was 278 nm, and the purity of each compound was detected by HPLC analysis. Spectral data analyses including UV, ESI-MS and NMR were used to identify their structures. This method is simple, fast, which is suitable for preparation of standard reference of ferulic acid, senkyunolide I and Senkyunolide H from L. chuanxiong and can meet the requirement of new drug research and development.

Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells.[Pubmed:8107327]

Jpn J Pharmacol. 1993 Nov;63(3):353-9.

Inhibitory effects of cnidium rhizome-derived phthalides on competence and progression phases of fetal bovine serum (10%)-induced proliferation were compared in primary cultures of mouse aorta smooth muscle cells (SMC). Their potencies for the competence inhibition were in the order of senkyunolide L ((Z)-6-hydroxy-7-chloro-6,7-dihydroligustilide) > Senkyunolide H ((Z)-6,7-dihydroxy-6,7-dihydroligustilide) > senkyunolide J ((3S)-(E)-6,7-dihydroxy-3,6,7,8-tetrahydroligustilide) > senkyunolide I ((E)-6,7-dihydroxy-6,7-dihydroligustilide) > ligustilide = senkyunolide A ((3S)-3,8-dihydroligustilide) > butylidenephthalide. The order of their potencies for the progression inhibition was parallel with that for the competence inhibition. Senkyunolide L is considered to have been formed during the extraction of cnidium. These results demonstrate that the (Z)-6,7-dihydroxy isomer of the dihydroligustilide derivatives is essential for the anti-competent effect on proliferation of the SMC in primary culture. Senkyunolide H in cnidium rhizome may be a prototype for a new anti-atherosclerotic drug.

Description

Senkyunolide H is a natural compound isolated from Ligusticum chuanxiong Hort.

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