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Spectinomycin dihydrochloride

CAS# 21736-83-4

Spectinomycin dihydrochloride

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Quality Control of Spectinomycin dihydrochloride

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Chemical structure

Spectinomycin dihydrochloride

3D structure

Chemical Properties of Spectinomycin dihydrochloride

Cas No. 21736-83-4 SDF Download SDF
PubChem ID 64740 Appearance Powder
Formula C14H26Cl2N2O7 M.Wt 405.27
Type of Compound N/A Storage Desiccate at -20°C
Solubility H2O : ≥ 100 mg/mL (246.75 mM)
*"≥" means soluble, but saturation unknown.
SMILES CC1CC(=O)C2(C(O1)OC3C(C(C(C(C3O2)NC)O)NC)O)O.Cl.Cl
Standard InChIKey FOGDPGQSHLLYIK-XYQGXRRISA-N
Standard InChI InChI=1S/C14H24N2O7.2ClH/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;/m1../s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Spectinomycin dihydrochloride

DescriptionSpectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis. Target: Antibacterial Spectinomycin is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. Spectinomycin binds to the 30S subunit of the bacterial ribosome and interrupts protein synthesis. One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida [1]. It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins. A resistance-conferring gene for spectinomycin can also be used as a selection marker in bacteria for molecular cloning purposes. Furthermore, Spectinomycin is used as a selection agent for transformed plant cells that contain the selectable marker gene Spcr [2].

References:
[1]. Kehrenberg, C. and S. Schwarz, Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida. Antimicrob Agents Chemother, 2007. 51(6): p. 2244-6. [2]. http://www.toku-e.com/Upload/Products/PDS/20120518003891.pdf

Spectinomycin dihydrochloride Dilution Calculator

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Preparing Stock Solutions of Spectinomycin dihydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4675 mL 12.3375 mL 24.6749 mL 49.3498 mL 61.6873 mL
5 mM 0.4935 mL 2.4675 mL 4.935 mL 9.87 mL 12.3375 mL
10 mM 0.2467 mL 1.2337 mL 2.4675 mL 4.935 mL 6.1687 mL
50 mM 0.0493 mL 0.2467 mL 0.4935 mL 0.987 mL 1.2337 mL
100 mM 0.0247 mL 0.1234 mL 0.2467 mL 0.4935 mL 0.6169 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Spectinomycin dihydrochloride

Spectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis.

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References on Spectinomycin dihydrochloride

HPLC-ELSD analysis of spectinomycin dihydrochloride and its impurities.[Pubmed:21710577]

J Sep Sci. 2011 Aug;34(15):1811-9.

A simple, rapid and reliable reversed-phase ion-pair chromatography method by HPLC coupled to an evaporative light scattering detector (ELSD) has been developed to simultaneously determine chloride, spectinomycin and its related substances in a sample. The column was a TSKgel ODS-100V. The mobile phase was ACN/aqueous solution of 15 mM ammonium acetate adjusted with TFA to pH 3.0 (2:98 v/v), in an isocratic mode. The drift tube temperature was set at 50 degrees C and the nebulizing gas flow rate of air was 3.5 L/min for ELSD detection. Almost all of the reported degradation compounds of spectinomycin such as actinamine, actinospectinoic acid and biosynthesis intermediates such as dihydrospectinomycin diastereoisomers were baseline separated. MS was utilized for the identification of spectinomycin and its seven related substances. The method for the assay of spectinomycin was successfully validated with respect to accuracy, precision (RSD less than 2%), linearity (throughout the linear range 0.025-3 mg/mL, r=0.9993), sensitivity (LOD: 100 ng on column) and robustness. The experimental results demonstrated that the simultaneous determination of chloride, spectinomycin and related substances is feasible in a single run, which suggests applicability in routine assays.

Determination of spectinomycin dihydrochloride by liquid chromatography with electrochemical detection.[Pubmed:2977438]

Pharm Res. 1988 Oct;5(10):664-7.

Spectinomycin dihydrochloride is determined by liquid chromatography with electrochemical detection. The drug is chromatographed on a reverse-phase Nucleosil C18 column using an eluent containing 0.02 M sodium citrate and 0.0015 M octyl sodium sulfate (pH 6.10 with perchloric acid) and acetonitrile (100:4). Detection is performed using a coulometric detector (porous carbon working electrode) at +0.85 V. The drug and primary degradation product are detectable. Detector response is linear to at least 20 micrograms/ml, which is four times the assay level. The procedure has relative standard deviations of +/- 1.21 to +/- 2.72% for three lots of bulk drug. Sensitivity is greater than 0.1 microgram/ml of spectinomycin (5 ng on column). Repeatability at this level is +/- 4.94%.

Description

Spectinomycin is an antibiotic which acts by binding to the 30S subunit of the bacterial ribosome and interrupting protein synthesis.

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