Synthalin sulfate

CAS# 182285-12-7

Synthalin sulfate

Catalog No. BCC6730----Order now to get a substantial discount!

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Chemical structure

Synthalin sulfate

3D structure

Chemical Properties of Synthalin sulfate

Cas No. 182285-12-7 SDF Download SDF
PubChem ID 44134960 Appearance Powder
Formula C12H30N6O4S M.Wt 354.47
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 5 mM in water
Chemical Name 2-[10-(diaminomethylideneamino)decyl]guanidine;sulfuric acid
SMILES C(CCCCCN=C(N)N)CCCCN=C(N)N.OS(=O)(=O)O
Standard InChIKey MNKRJRJDADVBJJ-UHFFFAOYSA-N
Standard InChI InChI=1S/C12H28N6.H2O4S/c13-11(14)17-9-7-5-3-1-2-4-6-8-10-18-12(15)16;1-5(2,3)4/h1-10H2,(H4,13,14,17)(H4,15,16,18);(H2,1,2,3,4)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Synthalin sulfate

DescriptionAn effective non-competitive NMDA receptor antagonist in vivo and in vitro; may bind to more than one site, one of which is the polyamine site.

Synthalin sulfate Dilution Calculator

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Synthalin sulfate Molarity Calculator

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Preparing Stock Solutions of Synthalin sulfate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8211 mL 14.1056 mL 28.2111 mL 56.4223 mL 70.5278 mL
5 mM 0.5642 mL 2.8211 mL 5.6422 mL 11.2845 mL 14.1056 mL
10 mM 0.2821 mL 1.4106 mL 2.8211 mL 5.6422 mL 7.0528 mL
50 mM 0.0564 mL 0.2821 mL 0.5642 mL 1.1284 mL 1.4106 mL
100 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.5642 mL 0.7053 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Synthalin sulfate

Interactions between zinc and spermidine on the N-methyl-D-aspartate receptor complex: clues to the mechanism of action of 1,10-bis(guanidino)decane and pentamidine.[Pubmed:1432693]

J Pharmacol Exp Ther. 1992 Nov;263(2):632-8.

This study investigated the mechanism of action of two novel, noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor using [3H]dizocilpine binding to rat brain membranes. Pentamidine and 1,10(bisguanidino)decane (BG10) inhibited [3H]dizocilpine binding in the concentration range of 1 to 100 microM, as did Zn++ and the competitive polyamine antagonist arcaine. The action of each of these agents was sensitive to the addition of spermidine to the assay. However, only arcaine interacted with spermidine in a competitive fashion. Spermidine decreased the apparent affinity of Zn++ and also increased the Hill slope of the Zn++ inhibition curves. BG10 and pentamidine inhibition of [3H]dizocilpine binding was less sensitive to spermidine. Calcium had similar effects to spermidine on the inhibition of [3H]dizocilpine binding by Zn++, arcaine, pentamidine and GB10, but was less potent than spermidine. Treating membranes with diethylpyrocarbonate, a histidine-modifying reagent, decreased the apparent affinity of Zn++ by more than 4-fold while having very modest effects on the actions of BG10, pentamidine and arcaine. In addition, Zn++ failed to slow the dissociation of [3H]dizocilpine in diethylpyrocarbonate-treated tissue, whereas the action of BG10 and pentamidine was qualitatively unaffected. These data show that the effects of BG10 and pentamidine on the NMDA receptor are complex and may involve more than one binding site for each drug. In addition, this study shows that the action of Zn++ on the NMDA receptor is modulated by polyamines. Finally, the mechanism of action of pentamidine and BG10 cannot be attributed to an action at the Zn++ recognition site.

1,10-bis(guanidino)decane inhibits N-methyl-D-aspartate responses in vitro and in vivo.[Pubmed:1658306]

J Pharmacol Exp Ther. 1991 Nov;259(2):626-32.

This study evaluated the interaction of the arcaine analog 1,10-bis(guanidino)decane (BG10) with the NMDA receptor. BG10 inhibited [3H]dizocilpine binding to well-washed rat brain membranes with an apparent affinity of 1.3 microM. The inhibition was not competitive with respect to glutamate or glycine, but was significantly altered by spermidine. However, unlike arcaine, BG10 slowed the dissociation of [3H]dizocilpine. BG10 also inhibited [3H]glycine binding at similar concentrations. BG10 inhibited N-methyl-D-aspartate (NMDA) and glycine-induced increases in intracellular Ca++ in cultured rat brain neurons monitored using the fluorescent dye, fura-2 (IC50 3 microM). This inhibition was not competitive with NMDA or glycine and could not be reversed by either spermidine or arcaine. BG10 also noncompetitively inhibited NMDA-stimulated cyclic GMP production in cerebellar slices from mouse brain. Finally, BG10 administered i.p. reduced harmaline-stimulated, NMDA-dependent cyclic GMP accumulation in mouse cerebellum in vivo (ED50 12.3 mg/kg). These data demonstrate that BG10 is a novel and effective NMDA receptor antagonist in vitro and in vivo.

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