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TC-A 2317 hydrochloride

Aurora kinase A inhibitor,potent and selective CAS# 1245907-03-2

TC-A 2317 hydrochloride

Catalog No. BCC2418----Order now to get a substantial discount!

Product Name & Size Price Stock
TC-A 2317 hydrochloride: 5mg $138 In Stock
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Quality Control of TC-A 2317 hydrochloride

Number of papers citing our products

Chemical structure

TC-A 2317 hydrochloride

3D structure

Chemical Properties of TC-A 2317 hydrochloride

Cas No. 1245907-03-2 SDF Download SDF
PubChem ID 46911725 Appearance Powder
Formula C19H29ClN6O M.Wt 392.93
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol
Chemical Name 2-[(6-hydroxy-6-methylheptan-2-yl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile;hydrochloride
SMILES CC1=CC(=NC(=C1C#N)NC(C)CCCC(C)(C)O)NC2=NNC(=C2)C.Cl
Standard InChIKey DXVATYHPJJPMIN-UHFFFAOYSA-N
Standard InChI InChI=1S/C19H28N6O.ClH/c1-12-9-16(22-17-10-14(3)24-25-17)23-18(15(12)11-20)21-13(2)7-6-8-19(4,5)26;/h9-10,13,26H,6-8H2,1-5H3,(H3,21,22,23,24,25);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of TC-A 2317 hydrochloride

DescriptionPotent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.

TC-A 2317 hydrochloride Dilution Calculator

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TC-A 2317 hydrochloride Molarity Calculator

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Preparing Stock Solutions of TC-A 2317 hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.545 mL 12.7249 mL 25.4498 mL 50.8997 mL 63.6246 mL
5 mM 0.509 mL 2.545 mL 5.09 mL 10.1799 mL 12.7249 mL
10 mM 0.2545 mL 1.2725 mL 2.545 mL 5.09 mL 6.3625 mL
50 mM 0.0509 mL 0.2545 mL 0.509 mL 1.018 mL 1.2725 mL
100 mM 0.0254 mL 0.1272 mL 0.2545 mL 0.509 mL 0.6362 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on TC-A 2317 hydrochloride

TC-A-2317 hydrochloride is a potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.

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References on TC-A 2317 hydrochloride

3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: selective Aurora A kinase inhibitors.[Pubmed:20573509]

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4709-11.

A new class of Aurora A kinase inhibitor was created by transforming 4-(5-methyl-3-pyrazoloamino)pyrimidine moiety of VX-680 to 3-cyano-6-(5-methyl-3pyrazoloamino)pyridine. Compound 6 exhibited a potent Aurora A kinase inhibitory activity, excellent selectivity to Aurora B kinase and other 60 kinases, good cell permeability and good PK profile. Therefore compound 6 was effective in antitumor mice model at a dose of 30 mg/kg po qd without decrease of body weight.

Description

Potent, selective Aurora kinase A inhibitor

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