Terazosin HCl

CAS# 70024-40-7

Terazosin HCl

Catalog No. BCC4354----Order now to get a substantial discount!

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Quality Control of Terazosin HCl

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Chemical structure

Terazosin HCl

3D structure

Chemical Properties of Terazosin HCl

Cas No. 70024-40-7 SDF Download SDF
PubChem ID 63016 Appearance Powder
Formula C19H30ClN5O6 M.Wt 459.92
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 50 mg/mL (108.71 mM; Need ultrasonic)
H2O : 12.5 mg/mL (27.18 mM; Need ultrasonic)
Chemical Name [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;dihydrate;hydrochloride
SMILES [H+].O.O.[Cl-].COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4
Standard InChIKey NZMOFYDMGFQZLS-UHFFFAOYSA-N
Standard InChI InChI=1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Terazosin HCl Dilution Calculator

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Terazosin HCl Molarity Calculator

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Preparing Stock Solutions of Terazosin HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1743 mL 10.8715 mL 21.7429 mL 43.4858 mL 54.3573 mL
5 mM 0.4349 mL 2.1743 mL 4.3486 mL 8.6972 mL 10.8715 mL
10 mM 0.2174 mL 1.0871 mL 2.1743 mL 4.3486 mL 5.4357 mL
50 mM 0.0435 mL 0.2174 mL 0.4349 mL 0.8697 mL 1.0871 mL
100 mM 0.0217 mL 0.1087 mL 0.2174 mL 0.4349 mL 0.5436 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Terazosin HCl

Terazosin HCl dihydrate is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH).

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References on Terazosin HCl

Alpha 1-adrenoceptor properties of terazosin HCl and its enantiomers in the human prostate and canine brain.[Pubmed:1347941]

Prostate. 1992;20(2):159-65.

The objective of the present study was to characterize the alpha 1-adrenoceptor binding properties of terazosin and its enantiomers in human prostate and canine brain. Human prostate adenomas were obtained from 7 males undergoing prostatectomy for symptomatic BPH and canine cerebral cortices were obtained from 6 male beagles. Competitive displacement experiments were carried out on these tissue homogenates in the presence of a constant concentration ([180 pM]) of 125I-Heat and varying concentrations of unlabelled terazosin and its enantiomers. The Ki of terazosin and its enantiomers were determined from these binding studies. The mean Ki of rac-terazosin, R(+)-terazosin, and S(-)-terazosin in human prostate was 3.6 nM, 3.8 nM, and 2.8 nM, respectively. The differences between these mean Ki values were not statistically significant. The mean Ki of rac-terazosin, R(+)-terazosin, and S(-)-terazosin in canine brain were 6.7 nM, 8.4 nM, and 5.6 nM, respectively. The differences between these mean Ki values were not significantly different. The mean Ki of terazosin and its enantiomers were consistently lower in the human prostate compared to canine brain (P less than 0.05). The present study does not provide any evidence suggesting differential effects of terazosin enantiomers on the human prostate. The twofold difference between the Ki values in the prostate and brain suggests that different subtypes of the alpha 1-receptor might be present in these tissues.

Description

Terazosin hydrochloride dihydrate is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride dihydrate works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride dihydrate has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment.

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